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Gene: ZBTB7B |
Gene summary for ZBTB7B |
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Gene information | Species | Human | Gene symbol | ZBTB7B | Gene ID | 51043 |
Gene name | zinc finger and BTB domain containing 7B | |
Gene Alias | CKROX | |
Cytomap | 1q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | O15156 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51043 | ZBTB7B | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.48e-06 | 6.39e-01 | 0.0131 |
51043 | ZBTB7B | HTA11_10623_2000001011 | Human | Colorectum | AD | 1.59e-06 | 6.76e-01 | -0.0177 |
51043 | ZBTB7B | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.85e-16 | 7.16e-01 | 0.0338 |
51043 | ZBTB7B | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.19e-02 | 2.42e-01 | 0.0674 |
51043 | ZBTB7B | HTA11_6818_2000001011 | Human | Colorectum | AD | 9.00e-27 | 1.61e+00 | 0.0112 |
51043 | ZBTB7B | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.53e-18 | 1.02e+00 | 0.0588 |
51043 | ZBTB7B | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.45e-57 | 1.40e+00 | 0.3005 |
51043 | ZBTB7B | LZE7T | Human | Esophagus | ESCC | 2.17e-11 | 1.79e-01 | 0.0667 |
51043 | ZBTB7B | LZE20T | Human | Esophagus | ESCC | 4.95e-09 | 6.50e-02 | 0.0662 |
51043 | ZBTB7B | LZE24T | Human | Esophagus | ESCC | 4.44e-07 | 2.46e-01 | 0.0596 |
51043 | ZBTB7B | P1T-E | Human | Esophagus | ESCC | 8.18e-04 | 4.04e-01 | 0.0875 |
51043 | ZBTB7B | P2T-E | Human | Esophagus | ESCC | 3.30e-12 | 2.77e-02 | 0.1177 |
51043 | ZBTB7B | P4T-E | Human | Esophagus | ESCC | 7.44e-10 | 5.52e-02 | 0.1323 |
51043 | ZBTB7B | P5T-E | Human | Esophagus | ESCC | 1.92e-17 | 1.58e-01 | 0.1327 |
51043 | ZBTB7B | P8T-E | Human | Esophagus | ESCC | 2.68e-10 | 6.64e-02 | 0.0889 |
51043 | ZBTB7B | P9T-E | Human | Esophagus | ESCC | 1.65e-09 | 2.76e-02 | 0.1131 |
51043 | ZBTB7B | P10T-E | Human | Esophagus | ESCC | 9.30e-11 | -6.31e-03 | 0.116 |
51043 | ZBTB7B | P11T-E | Human | Esophagus | ESCC | 2.17e-03 | 8.62e-02 | 0.1426 |
51043 | ZBTB7B | P12T-E | Human | Esophagus | ESCC | 7.17e-09 | 1.32e-01 | 0.1122 |
51043 | ZBTB7B | P15T-E | Human | Esophagus | ESCC | 8.10e-13 | 2.35e-01 | 0.1149 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00903122 | Esophagus | ESCC | positive regulation of protein deacetylation | 20/8552 | 25/18723 | 4.81e-04 | 2.69e-03 | 20 |
GO:002240720 | Esophagus | ESCC | regulation of cell-cell adhesion | 239/8552 | 448/18723 | 5.88e-04 | 3.19e-03 | 239 |
GO:000268316 | Esophagus | ESCC | negative regulation of immune system process | 231/8552 | 434/18723 | 8.48e-04 | 4.36e-03 | 231 |
GO:004211018 | Esophagus | ESCC | T cell activation | 256/8552 | 487/18723 | 1.18e-03 | 5.87e-03 | 256 |
GO:19031317 | Esophagus | ESCC | mononuclear cell differentiation | 226/8552 | 426/18723 | 1.20e-03 | 5.88e-03 | 226 |
GO:00329335 | Esophagus | ESCC | SREBP signaling pathway | 13/8552 | 15/18723 | 1.31e-03 | 6.26e-03 | 13 |
GO:002240919 | Esophagus | ESCC | positive regulation of cell-cell adhesion | 155/8552 | 284/18723 | 1.50e-03 | 7.06e-03 | 155 |
GO:190210510 | Esophagus | ESCC | regulation of leukocyte differentiation | 152/8552 | 279/18723 | 1.82e-03 | 8.35e-03 | 152 |
GO:000181916 | Esophagus | ESCC | positive regulation of cytokine production | 244/8552 | 467/18723 | 2.29e-03 | 1.01e-02 | 244 |
GO:00310652 | Esophagus | ESCC | positive regulation of histone deacetylation | 15/8552 | 19/18723 | 3.29e-03 | 1.35e-02 | 15 |
GO:00715015 | Esophagus | ESCC | cellular response to sterol depletion | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:00456213 | Esophagus | ESCC | positive regulation of lymphocyte differentiation | 61/8552 | 104/18723 | 5.22e-03 | 1.97e-02 | 61 |
GO:00455984 | Esophagus | ESCC | regulation of fat cell differentiation | 79/8552 | 139/18723 | 5.23e-03 | 1.97e-02 | 79 |
GO:00069914 | Esophagus | ESCC | response to sterol depletion | 14/8552 | 18/18723 | 5.77e-03 | 2.14e-02 | 14 |
GO:01201624 | Esophagus | ESCC | positive regulation of cold-induced thermogenesis | 57/8552 | 97/18723 | 6.43e-03 | 2.35e-02 | 57 |
GO:005087015 | Esophagus | ESCC | positive regulation of T cell activation | 117/8552 | 216/18723 | 7.23e-03 | 2.62e-02 | 117 |
GO:00302176 | Esophagus | ESCC | T cell differentiation | 137/8552 | 257/18723 | 8.09e-03 | 2.87e-02 | 137 |
GO:190303916 | Esophagus | ESCC | positive regulation of leukocyte cell-cell adhesion | 128/8552 | 239/18723 | 8.40e-03 | 2.96e-02 | 128 |
GO:00082869 | Esophagus | ESCC | insulin receptor signaling pathway | 66/8552 | 116/18723 | 9.76e-03 | 3.37e-02 | 66 |
GO:000715918 | Esophagus | ESCC | leukocyte cell-cell adhesion | 192/8552 | 371/18723 | 1.03e-02 | 3.51e-02 | 192 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ZBTB7B | SNV | Missense_Mutation | novel | c.1385N>A | p.Arg462Gln | p.R462Q | O15156 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C8-A26Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | CR |
ZBTB7B | SNV | Missense_Mutation | c.110N>A | p.Ser37Asn | p.S37N | O15156 | protein_coding | tolerated(0.53) | probably_damaging(0.969) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB7B | SNV | Missense_Mutation | c.1024N>C | p.Asp342His | p.D342H | O15156 | protein_coding | deleterious(0.04) | probably_damaging(0.988) | TCGA-D8-A27I-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adrimycin+cyclophosphamide | SD | |
ZBTB7B | SNV | Missense_Mutation | c.895N>A | p.Glu299Lys | p.E299K | O15156 | protein_coding | tolerated(0.25) | benign(0.222) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZBTB7B | SNV | Missense_Mutation | c.232G>A | p.Glu78Lys | p.E78K | O15156 | protein_coding | deleterious(0.01) | benign(0.161) | TCGA-VS-A958-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
ZBTB7B | insertion | In_Frame_Ins | novel | c.690_691insCCCAAA | p.Pro230_Val231insProLys | p.P230_V231insPK | O15156 | protein_coding | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
ZBTB7B | SNV | Missense_Mutation | c.1120N>T | p.Arg374Cys | p.R374C | O15156 | protein_coding | deleterious(0.02) | probably_damaging(0.998) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ZBTB7B | SNV | Missense_Mutation | c.274T>C | p.Tyr92His | p.Y92H | O15156 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3680-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | folinic | PD | |
ZBTB7B | SNV | Missense_Mutation | c.968N>T | p.Gly323Val | p.G323V | O15156 | protein_coding | tolerated(0.07) | probably_damaging(0.977) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD | |
ZBTB7B | SNV | Missense_Mutation | c.651G>T | p.Gln217His | p.Q217H | O15156 | protein_coding | tolerated(0.39) | probably_damaging(0.923) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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