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Gene: WBP1 |
Gene summary for WBP1 |
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Gene information | Species | Human | Gene symbol | WBP1 | Gene ID | 23559 |
Gene name | WW domain binding protein 1 | |
Gene Alias | WBP-1 | |
Cytomap | 2p13.1 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | Q96G27 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23559 | WBP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.08e-08 | 1.93e-01 | 0.0155 |
23559 | WBP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.65e-07 | 2.41e-01 | -0.1808 |
23559 | WBP1 | HTA11_2951_2000001011 | Human | Colorectum | AD | 3.34e-04 | 2.80e-01 | 0.0216 |
23559 | WBP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 6.59e-07 | 2.76e-01 | -0.0811 |
23559 | WBP1 | HTA11_78_2000001011 | Human | Colorectum | AD | 8.38e-10 | 2.70e-01 | -0.1088 |
23559 | WBP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 3.42e-16 | 3.03e-01 | -0.1954 |
23559 | WBP1 | HTA11_411_2000001011 | Human | Colorectum | SER | 5.61e-03 | 4.03e-01 | -0.2602 |
23559 | WBP1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 6.03e-08 | 2.57e-01 | -0.1207 |
23559 | WBP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 7.35e-06 | 2.45e-01 | -0.1526 |
23559 | WBP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 6.35e-15 | 2.94e-01 | -0.1464 |
23559 | WBP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 4.47e-08 | 1.81e-01 | -0.1001 |
23559 | WBP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 5.12e-18 | 4.26e-01 | -0.059 |
23559 | WBP1 | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.28e-02 | 2.15e-01 | -0.2061 |
23559 | WBP1 | HTA11_5216_2000001011 | Human | Colorectum | SER | 3.40e-02 | 2.52e-01 | -0.1462 |
23559 | WBP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 4.83e-05 | 2.30e-01 | -0.0842 |
23559 | WBP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.77e-13 | 3.09e-01 | 0.096 |
23559 | WBP1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.03e-06 | 3.36e-01 | 0.0446 |
23559 | WBP1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 6.03e-05 | 4.04e-01 | 0.0451 |
23559 | WBP1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.49e-06 | 3.07e-01 | 0.0528 |
23559 | WBP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 7.76e-07 | 3.59e-01 | 0.0131 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000398112 | Skin | cSCC | mRNA splicing, via spliceosome | 197/4864 | 320/18723 | 1.45e-41 | 1.14e-38 | 197 |
GO:001607224 | Skin | cSCC | rRNA metabolic process | 158/4864 | 236/18723 | 4.06e-40 | 2.83e-37 | 158 |
GO:003447017 | Skin | cSCC | ncRNA processing | 215/4864 | 395/18723 | 6.83e-34 | 4.28e-31 | 215 |
GO:003466013 | Skin | cSCC | ncRNA metabolic process | 234/4864 | 485/18723 | 1.37e-26 | 4.77e-24 | 234 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0008380113 | Thyroid | PTC | RNA splicing | 273/5968 | 434/18723 | 4.44e-41 | 1.40e-37 | 273 |
GO:0042254113 | Thyroid | PTC | ribosome biogenesis | 202/5968 | 299/18723 | 3.47e-37 | 5.47e-34 | 202 |
GO:0006364112 | Thyroid | PTC | rRNA processing | 156/5968 | 225/18723 | 5.58e-31 | 5.03e-28 | 156 |
GO:0016072112 | Thyroid | PTC | rRNA metabolic process | 160/5968 | 236/18723 | 5.68e-30 | 3.58e-27 | 160 |
GO:0000375113 | Thyroid | PTC | RNA splicing, via transesterification reactions | 202/5968 | 324/18723 | 6.81e-30 | 3.91e-27 | 202 |
GO:0000377113 | Thyroid | PTC | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:0000398113 | Thyroid | PTC | mRNA splicing, via spliceosome | 199/5968 | 320/18723 | 2.96e-29 | 1.44e-26 | 199 |
GO:003447018 | Thyroid | PTC | ncRNA processing | 215/5968 | 395/18723 | 7.14e-21 | 1.22e-18 | 215 |
GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
GO:002261334 | Thyroid | ATC | ribonucleoprotein complex biogenesis | 292/6293 | 463/18723 | 3.05e-39 | 9.63e-36 | 292 |
GO:000838034 | Thyroid | ATC | RNA splicing | 270/6293 | 434/18723 | 7.50e-35 | 1.19e-31 | 270 |
GO:004225434 | Thyroid | ATC | ribosome biogenesis | 203/6293 | 299/18723 | 3.63e-34 | 4.59e-31 | 203 |
GO:000636432 | Thyroid | ATC | rRNA processing | 157/6293 | 225/18723 | 9.02e-29 | 5.70e-26 | 157 |
GO:001607232 | Thyroid | ATC | rRNA metabolic process | 161/6293 | 236/18723 | 1.02e-27 | 5.89e-25 | 161 |
GO:000037534 | Thyroid | ATC | RNA splicing, via transesterification reactions | 200/6293 | 324/18723 | 1.75e-25 | 7.39e-23 | 200 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
WBP1 | SNV | Missense_Mutation | novel | c.249N>T | p.Arg83Ser | p.R83S | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-E9-A3HO-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
WBP1 | SNV | Missense_Mutation | novel | c.274N>C | p.Glu92Gln | p.E92Q | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
WBP1 | SNV | Missense_Mutation | c.31N>C | p.Glu11Gln | p.E11Q | Q96G27 | protein_coding | deleterious_low_confidence(0.01) | benign(0.171) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
WBP1 | insertion | Frame_Shift_Ins | rs547055147 | c.551dupC | p.His185SerfsTer5 | p.H185Sfs*5 | Q96G27 | protein_coding | TCGA-C5-A7CM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
WBP1 | SNV | Missense_Mutation | c.458N>A | p.Ser153Asn | p.S153N | Q96G27 | protein_coding | deleterious(0.04) | benign(0) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
WBP1 | SNV | Missense_Mutation | novel | c.278N>A | p.Ile93Asn | p.I93N | Q96G27 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delN | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-A6-2672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | ||
WBP1 | deletion | Frame_Shift_Del | c.545delN | p.Pro184LeufsTer11 | p.P184Lfs*11 | Q96G27 | protein_coding | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |||
WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delT | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-AA-3845-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
WBP1 | deletion | Frame_Shift_Del | rs773064295 | c.552delN | p.His185IlefsTer10 | p.H185Ifs*10 | Q96G27 | protein_coding | TCGA-DM-A1HB-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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