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Gene: UMPS |
Gene summary for UMPS |
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Gene information | Species | Human | Gene symbol | UMPS | Gene ID | 7372 |
Gene name | uridine monophosphate synthetase | |
Gene Alias | OPRT | |
Cytomap | 3q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A8K5J1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7372 | UMPS | CCI_3 | Human | Cervix | CC | 5.69e-06 | 5.19e-01 | 0.516 |
7372 | UMPS | LZE2T | Human | Esophagus | ESCC | 5.60e-06 | 5.95e-01 | 0.082 |
7372 | UMPS | LZE4T | Human | Esophagus | ESCC | 1.79e-07 | 2.54e-01 | 0.0811 |
7372 | UMPS | LZE7T | Human | Esophagus | ESCC | 3.31e-12 | 5.86e-01 | 0.0667 |
7372 | UMPS | LZE24T | Human | Esophagus | ESCC | 2.44e-08 | 2.30e-01 | 0.0596 |
7372 | UMPS | P1T-E | Human | Esophagus | ESCC | 1.28e-06 | 3.95e-01 | 0.0875 |
7372 | UMPS | P2T-E | Human | Esophagus | ESCC | 3.23e-15 | 4.56e-01 | 0.1177 |
7372 | UMPS | P4T-E | Human | Esophagus | ESCC | 1.21e-13 | 3.04e-01 | 0.1323 |
7372 | UMPS | P5T-E | Human | Esophagus | ESCC | 1.41e-23 | 5.70e-01 | 0.1327 |
7372 | UMPS | P8T-E | Human | Esophagus | ESCC | 2.22e-17 | 3.98e-01 | 0.0889 |
7372 | UMPS | P9T-E | Human | Esophagus | ESCC | 1.09e-21 | 4.78e-01 | 0.1131 |
7372 | UMPS | P10T-E | Human | Esophagus | ESCC | 6.34e-37 | 6.73e-01 | 0.116 |
7372 | UMPS | P11T-E | Human | Esophagus | ESCC | 2.35e-10 | 4.50e-01 | 0.1426 |
7372 | UMPS | P12T-E | Human | Esophagus | ESCC | 2.32e-21 | 3.96e-01 | 0.1122 |
7372 | UMPS | P15T-E | Human | Esophagus | ESCC | 1.41e-32 | 6.56e-01 | 0.1149 |
7372 | UMPS | P16T-E | Human | Esophagus | ESCC | 1.44e-31 | 6.14e-01 | 0.1153 |
7372 | UMPS | P17T-E | Human | Esophagus | ESCC | 5.60e-07 | 3.43e-01 | 0.1278 |
7372 | UMPS | P19T-E | Human | Esophagus | ESCC | 2.19e-04 | 4.72e-01 | 0.1662 |
7372 | UMPS | P20T-E | Human | Esophagus | ESCC | 3.39e-15 | 3.33e-01 | 0.1124 |
7372 | UMPS | P21T-E | Human | Esophagus | ESCC | 3.07e-21 | 4.58e-01 | 0.1617 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000941022 | Liver | HCC | response to xenobiotic stimulus | 248/7958 | 462/18723 | 6.47e-07 | 1.02e-05 | 248 |
GO:00091122 | Liver | HCC | nucleobase metabolic process | 28/7958 | 34/18723 | 2.21e-06 | 2.99e-05 | 28 |
GO:000912311 | Liver | HCC | nucleoside monophosphate metabolic process | 52/7958 | 76/18723 | 4.35e-06 | 5.54e-05 | 52 |
GO:00091612 | Liver | HCC | ribonucleoside monophosphate metabolic process | 41/7958 | 58/18723 | 1.29e-05 | 1.44e-04 | 41 |
GO:00062201 | Liver | HCC | pyrimidine nucleotide metabolic process | 36/7958 | 50/18723 | 2.28e-05 | 2.41e-04 | 36 |
GO:00062062 | Liver | HCC | pyrimidine nucleobase metabolic process | 15/7958 | 16/18723 | 2.55e-05 | 2.66e-04 | 15 |
GO:00461121 | Liver | HCC | nucleobase biosynthetic process | 16/7958 | 18/18723 | 6.21e-05 | 5.68e-04 | 16 |
GO:19016571 | Liver | HCC | glycosyl compound metabolic process | 55/7958 | 88/18723 | 1.20e-04 | 1.01e-03 | 55 |
GO:00091241 | Liver | HCC | nucleoside monophosphate biosynthetic process | 29/7958 | 42/18723 | 4.57e-04 | 3.04e-03 | 29 |
GO:00091291 | Liver | HCC | pyrimidine nucleoside monophosphate metabolic process | 16/7958 | 20/18723 | 7.15e-04 | 4.37e-03 | 16 |
GO:005087822 | Liver | HCC | regulation of body fluid levels | 191/7958 | 379/18723 | 1.06e-03 | 6.11e-03 | 191 |
GO:00091731 | Liver | HCC | pyrimidine ribonucleoside monophosphate metabolic process | 12/7958 | 14/18723 | 1.17e-03 | 6.54e-03 | 12 |
GO:00460491 | Liver | HCC | UMP metabolic process | 12/7958 | 14/18723 | 1.17e-03 | 6.54e-03 | 12 |
GO:00725271 | Liver | HCC | pyrimidine-containing compound metabolic process | 49/7958 | 82/18723 | 1.20e-03 | 6.68e-03 | 49 |
GO:00091561 | Liver | HCC | ribonucleoside monophosphate biosynthetic process | 23/7958 | 33/18723 | 1.46e-03 | 7.75e-03 | 23 |
GO:0072528 | Liver | HCC | pyrimidine-containing compound biosynthetic process | 24/7958 | 35/18723 | 1.64e-03 | 8.61e-03 | 24 |
GO:0006221 | Liver | HCC | pyrimidine nucleotide biosynthetic process | 21/7958 | 30/18723 | 2.15e-03 | 1.08e-02 | 21 |
GO:00308795 | Liver | HCC | mammary gland development | 75/7958 | 137/18723 | 2.52e-03 | 1.22e-02 | 75 |
GO:00092181 | Liver | HCC | pyrimidine ribonucleotide metabolic process | 20/7958 | 29/18723 | 3.61e-03 | 1.60e-02 | 20 |
GO:00714662 | Liver | HCC | cellular response to xenobiotic stimulus | 93/7958 | 177/18723 | 4.35e-03 | 1.89e-02 | 93 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012405 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa0124012 | Esophagus | ESCC | Biosynthesis of cofactors | 97/4205 | 153/8465 | 3.88e-04 | 1.35e-03 | 6.94e-04 | 97 |
hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa01240 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa00240 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa00983 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012401 | Liver | Cirrhotic | Biosynthesis of cofactors | 66/2530 | 153/8465 | 3.11e-04 | 1.99e-03 | 1.23e-03 | 66 |
hsa002401 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa009831 | Liver | Cirrhotic | Drug metabolism - other enzymes | 34/2530 | 80/8465 | 1.08e-02 | 3.57e-02 | 2.20e-02 | 34 |
hsa012402 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa009832 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012403 | Liver | HCC | Biosynthesis of cofactors | 103/4020 | 153/8465 | 4.67e-07 | 5.05e-06 | 2.81e-06 | 103 |
hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa009833 | Liver | HCC | Drug metabolism - other enzymes | 54/4020 | 80/8465 | 2.25e-04 | 1.09e-03 | 6.08e-04 | 54 |
hsa012404 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa002404 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0124011 | Oral cavity | OSCC | Biosynthesis of cofactors | 88/3704 | 153/8465 | 3.84e-04 | 1.20e-03 | 6.12e-04 | 88 |
hsa0024011 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
UMPS | SNV | Missense_Mutation | c.894N>C | p.Leu298Phe | p.L298F | P11172 | protein_coding | deleterious(0) | probably_damaging(0.975) | TCGA-A2-A0SY-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | arimidex | SD | |
UMPS | SNV | Missense_Mutation | c.459G>C | p.Leu153Phe | p.L153F | P11172 | protein_coding | deleterious(0.01) | possibly_damaging(0.864) | TCGA-A8-A08R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UMPS | SNV | Missense_Mutation | rs779077289 | c.811N>C | p.Asp271His | p.D271H | P11172 | protein_coding | deleterious(0.01) | possibly_damaging(0.834) | TCGA-BH-A18V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UMPS | SNV | Missense_Mutation | c.1171G>A | p.Glu391Lys | p.E391K | P11172 | protein_coding | tolerated(0.15) | benign(0.096) | TCGA-LD-A74U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | taxotere | SD | |
UMPS | SNV | Missense_Mutation | novel | c.688C>T | p.Arg230Cys | p.R230C | P11172 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
UMPS | SNV | Missense_Mutation | c.1171N>A | p.Glu391Lys | p.E391K | P11172 | protein_coding | tolerated(0.15) | benign(0.096) | TCGA-FU-A23L-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
UMPS | SNV | Missense_Mutation | novel | c.20C>T | p.Ala7Val | p.A7V | P11172 | protein_coding | tolerated(0.08) | benign(0.001) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
UMPS | SNV | Missense_Mutation | c.941A>C | p.Lys314Thr | p.K314T | P11172 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
UMPS | SNV | Missense_Mutation | novel | c.1267N>A | p.Ala423Thr | p.A423T | P11172 | protein_coding | tolerated(0.38) | benign(0.006) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
UMPS | SNV | Missense_Mutation | novel | c.340N>G | p.Asn114Asp | p.N114D | P11172 | protein_coding | tolerated(0.33) | benign(0.035) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7372 | UMPS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE | capecitabine | CAPECITABINE | 20647221,28347776,16818689 | |
7372 | UMPS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE | fluorouracil | FLUOROURACIL | 20647221,16818689 | |
7372 | UMPS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE | 5-FLUORO-6-AMIDO-UMP | CHEMBL1164954 | 20452222 | |
7372 | UMPS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE | tegafur | TEGAFUR | 20647221,16818689 | |
7372 | UMPS | ENZYME, DRUGGABLE GENOME, CLINICALLY ACTIONABLE | leucovorin | LEUCOVORIN | 20647221,16818689 |
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