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Gene: TXNRD1 |
Gene summary for TXNRD1 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | TXNRD1 | Gene ID | 7296 |
| Gene name | thioredoxin reductase 1 | |
| Gene Alias | GRIM-12 | |
| Cytomap | 12q23.3 | |
| Gene Type | protein-coding | GO ID | GO:0001704 | UniProtAcc | Q16881 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 7296 | TXNRD1 | CCI_2 | Human | Cervix | CC | 6.19e-19 | 1.44e+00 | 0.5249 |
| 7296 | TXNRD1 | AEH-subject1 | Human | Endometrium | AEH | 6.82e-10 | 3.73e-01 | -0.3059 |
| 7296 | TXNRD1 | AEH-subject2 | Human | Endometrium | AEH | 1.87e-06 | 3.28e-01 | -0.2525 |
| 7296 | TXNRD1 | AEH-subject3 | Human | Endometrium | AEH | 3.84e-25 | 6.86e-01 | -0.2576 |
| 7296 | TXNRD1 | AEH-subject4 | Human | Endometrium | AEH | 4.74e-14 | 5.15e-01 | -0.2657 |
| 7296 | TXNRD1 | AEH-subject5 | Human | Endometrium | AEH | 2.36e-14 | 5.39e-01 | -0.2953 |
| 7296 | TXNRD1 | EEC-subject1 | Human | Endometrium | EEC | 4.38e-11 | 3.65e-01 | -0.2682 |
| 7296 | TXNRD1 | EEC-subject2 | Human | Endometrium | EEC | 1.39e-16 | 4.56e-01 | -0.2607 |
| 7296 | TXNRD1 | EEC-subject3 | Human | Endometrium | EEC | 4.39e-25 | 6.57e-01 | -0.2525 |
| 7296 | TXNRD1 | EEC-subject4 | Human | Endometrium | EEC | 1.99e-08 | 3.44e-01 | -0.2571 |
| 7296 | TXNRD1 | EEC-subject5 | Human | Endometrium | EEC | 5.14e-05 | 3.23e-01 | -0.249 |
| 7296 | TXNRD1 | GSM5276934 | Human | Endometrium | EEC | 1.74e-24 | 7.23e-01 | -0.0913 |
| 7296 | TXNRD1 | GSM5276937 | Human | Endometrium | EEC | 3.38e-51 | 1.13e+00 | -0.0897 |
| 7296 | TXNRD1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.65e-11 | 7.89e-02 | -0.1869 |
| 7296 | TXNRD1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 2.19e-08 | -6.54e-02 | -0.1875 |
| 7296 | TXNRD1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 2.03e-09 | 4.10e-03 | -0.1883 |
| 7296 | TXNRD1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 7.39e-07 | 4.53e-02 | -0.1934 |
| 7296 | TXNRD1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 3.91e-12 | 1.72e-01 | -0.1917 |
| 7296 | TXNRD1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 1.67e-11 | 1.33e-02 | -0.1916 |
| 7296 | TXNRD1 | LZE2T | Human | Esophagus | ESCC | 4.85e-05 | 9.38e-01 | 0.082 |
| Page: 1 2 3 4 5 6 7 8 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Endometrium |  | AEH: Atypical endometrial hyperplasia |
| EEC: Endometrioid Cancer | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Prostate |  | BPH: Benign Prostatic Hyperplasia |
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00483321 | Skin | AK | mesoderm morphogenesis | 15/1910 | 74/18723 | 7.07e-03 | 3.63e-02 | 15 |
| GO:000736914 | Skin | SCCIS | gastrulation | 24/919 | 185/18723 | 1.33e-05 | 4.40e-04 | 24 |
| GO:000170413 | Skin | SCCIS | formation of primary germ layer | 15/919 | 121/18723 | 8.61e-04 | 1.14e-02 | 15 |
| GO:004545420 | Skin | cSCC | cell redox homeostasis | 19/4864 | 35/18723 | 3.37e-04 | 2.67e-03 | 19 |
| GO:0097237111 | Skin | cSCC | cellular response to toxic substance | 45/4864 | 124/18723 | 7.08e-03 | 3.40e-02 | 45 |
| GO:0009636110 | Skin | cSCC | response to toxic substance | 86/4864 | 262/18723 | 7.66e-03 | 3.57e-02 | 86 |
| GO:1990748111 | Skin | cSCC | cellular detoxification | 42/4864 | 116/18723 | 9.45e-03 | 4.25e-02 | 42 |
| GO:000963627 | Thyroid | HT | response to toxic substance | 50/1272 | 262/18723 | 2.25e-11 | 3.75e-09 | 50 |
| GO:199074827 | Thyroid | HT | cellular detoxification | 31/1272 | 116/18723 | 2.29e-11 | 3.75e-09 | 31 |
| GO:009875420 | Thyroid | HT | detoxification | 36/1272 | 152/18723 | 2.63e-11 | 4.07e-09 | 36 |
| GO:009723727 | Thyroid | HT | cellular response to toxic substance | 32/1272 | 124/18723 | 3.00e-11 | 4.51e-09 | 32 |
| GO:009886926 | Thyroid | HT | cellular oxidant detoxification | 26/1272 | 101/18723 | 2.23e-09 | 2.26e-07 | 26 |
| GO:004545422 | Thyroid | HT | cell redox homeostasis | 10/1272 | 35/18723 | 7.73e-05 | 1.38e-03 | 10 |
| GO:0009636111 | Thyroid | PTC | response to toxic substance | 115/5968 | 262/18723 | 2.70e-05 | 2.63e-04 | 115 |
| GO:0045454110 | Thyroid | PTC | cell redox homeostasis | 23/5968 | 35/18723 | 4.02e-05 | 3.68e-04 | 23 |
| GO:000736910 | Thyroid | PTC | gastrulation | 84/5968 | 185/18723 | 7.58e-05 | 6.52e-04 | 84 |
| GO:1990748112 | Thyroid | PTC | cellular detoxification | 56/5968 | 116/18723 | 1.63e-04 | 1.26e-03 | 56 |
| GO:0097237112 | Thyroid | PTC | cellular response to toxic substance | 59/5968 | 124/18723 | 1.83e-04 | 1.39e-03 | 59 |
| GO:00017046 | Thyroid | PTC | formation of primary germ layer | 57/5968 | 121/18723 | 3.23e-04 | 2.23e-03 | 57 |
| GO:0098869111 | Thyroid | PTC | cellular oxidant detoxification | 49/5968 | 101/18723 | 3.52e-04 | 2.41e-03 | 49 |
| Page: 1 2 3 4 5 6 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa0522510 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
| hsa0522513 | Cervix | CC | Hepatocellular carcinoma | 40/1267 | 168/8465 | 1.52e-03 | 6.39e-03 | 3.78e-03 | 40 |
| hsa0522518 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
| hsa0522519 | Esophagus | ESCC | Hepatocellular carcinoma | 109/4205 | 168/8465 | 4.27e-05 | 1.88e-04 | 9.64e-05 | 109 |
| hsa052258 | Liver | HCC | Hepatocellular carcinoma | 106/4020 | 168/8465 | 2.87e-05 | 1.85e-04 | 1.03e-04 | 106 |
| hsa0522511 | Liver | HCC | Hepatocellular carcinoma | 106/4020 | 168/8465 | 2.87e-05 | 1.85e-04 | 1.03e-04 | 106 |
| hsa0522516 | Oral cavity | OSCC | Hepatocellular carcinoma | 97/3704 | 168/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 97 |
| hsa0522517 | Oral cavity | OSCC | Hepatocellular carcinoma | 97/3704 | 168/8465 | 1.63e-04 | 5.52e-04 | 2.81e-04 | 97 |
| hsa0522514 | Prostate | BPH | Hepatocellular carcinoma | 51/1718 | 168/8465 | 1.17e-03 | 5.22e-03 | 3.23e-03 | 51 |
| hsa0522515 | Prostate | BPH | Hepatocellular carcinoma | 51/1718 | 168/8465 | 1.17e-03 | 5.22e-03 | 3.23e-03 | 51 |
| hsa0522522 | Prostate | Tumor | Hepatocellular carcinoma | 53/1791 | 168/8465 | 9.65e-04 | 4.44e-03 | 2.75e-03 | 53 |
| hsa0522532 | Prostate | Tumor | Hepatocellular carcinoma | 53/1791 | 168/8465 | 9.65e-04 | 4.44e-03 | 2.75e-03 | 53 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| TXNRD1 | SNV | Missense_Mutation | novel | c.1312N>G | p.Met438Val | p.M438V | Q16881 | protein_coding | tolerated(0.1) | benign(0.006) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TXNRD1 | SNV | Missense_Mutation | rs773469710 | c.387N>C | p.Lys129Asn | p.K129N | Q16881 | protein_coding | tolerated(0.11) | benign(0.001) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
| TXNRD1 | SNV | Missense_Mutation | c.961N>T | p.Pro321Ser | p.P321S | Q16881 | protein_coding | deleterious(0) | probably_damaging(0.934) | TCGA-E9-A1R2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR | |
| TXNRD1 | SNV | Missense_Mutation | novel | c.1810G>A | p.Ala604Thr | p.A604T | Q16881 | protein_coding | tolerated(0.08) | benign(0.07) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
| TXNRD1 | SNV | Missense_Mutation | c.1609N>C | p.Glu537Gln | p.E537Q | Q16881 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-DS-A0VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| TXNRD1 | SNV | Missense_Mutation | rs369684801 | c.1750N>T | p.Arg584Cys | p.R584C | Q16881 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
| TXNRD1 | SNV | Missense_Mutation | novel | c.175N>T | p.Leu59Phe | p.L59F | Q16881 | protein_coding | deleterious(0.01) | benign(0.025) | TCGA-VS-A8EB-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | PD |
| TXNRD1 | SNV | Missense_Mutation | rs769989720 | c.232C>T | p.Arg78Cys | p.R78C | Q16881 | protein_coding | tolerated(0.15) | benign(0.251) | TCGA-VS-A9U6-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD |
| TXNRD1 | SNV | Missense_Mutation | novel | c.994N>T | p.Asp332Tyr | p.D332Y | Q16881 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| TXNRD1 | SNV | Missense_Mutation | c.956N>A | p.Gly319Asp | p.G319D | Q16881 | protein_coding | tolerated(0.91) | benign(0.006) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| Page: 1 2 3 4 5 6 7 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| 7296 | TXNRD1 | DRUGGABLE GENOME | 4-aryl quinol derivative 7 | |||
| 7296 | TXNRD1 | DRUGGABLE GENOME | ARSENIC TRIOXIDE | |||
| 7296 | TXNRD1 | DRUGGABLE GENOME | Binuclear gold(I) compound 1 | |||
| 7296 | TXNRD1 | DRUGGABLE GENOME | Disulfide compound 1 | |||
| 7296 | TXNRD1 | DRUGGABLE GENOME | Metal complex derivative 3 | |||
| 7296 | TXNRD1 | DRUGGABLE GENOME | inhibitor | CHEMBL1200978 | ARSENIC TRIOXIDE | |
| 7296 | TXNRD1 | DRUGGABLE GENOME | Terpyridineplatinum(II) complexe 2 | |||
| 7296 | TXNRD1 | DRUGGABLE GENOME | Fotemustine | FOTEMUSTINE | ||
| 7296 | TXNRD1 | DRUGGABLE GENOME | 4-aryl quinol derivative 4 | |||
| 7296 | TXNRD1 | DRUGGABLE GENOME | vitamin c | 23913015 |
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