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Gene: TXN |
Gene summary for TXN |
Gene summary. |
Gene information | Species | Human | Gene symbol | TXN | Gene ID | 7295 |
Gene name | thioredoxin | |
Gene Alias | TRDX | |
Cytomap | 9q31.3 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | P10599 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7295 | TXN | GSM4909281 | Human | Breast | IDC | 4.68e-03 | 1.92e-01 | 0.21 |
7295 | TXN | GSM4909286 | Human | Breast | IDC | 1.54e-15 | -2.14e-01 | 0.1081 |
7295 | TXN | GSM4909290 | Human | Breast | IDC | 6.89e-09 | 2.79e-01 | 0.2096 |
7295 | TXN | GSM4909293 | Human | Breast | IDC | 3.19e-06 | -1.19e-01 | 0.1581 |
7295 | TXN | GSM4909294 | Human | Breast | IDC | 5.49e-10 | 4.08e-02 | 0.2022 |
7295 | TXN | GSM4909296 | Human | Breast | IDC | 2.05e-04 | -3.93e-02 | 0.1524 |
7295 | TXN | GSM4909297 | Human | Breast | IDC | 1.05e-21 | -1.83e-01 | 0.1517 |
7295 | TXN | GSM4909299 | Human | Breast | IDC | 2.70e-03 | -2.26e-01 | 0.035 |
7295 | TXN | GSM4909301 | Human | Breast | IDC | 1.16e-04 | 1.97e-01 | 0.1577 |
7295 | TXN | GSM4909302 | Human | Breast | IDC | 3.66e-08 | -4.10e-01 | 0.1545 |
7295 | TXN | GSM4909304 | Human | Breast | IDC | 3.68e-07 | -2.24e-01 | 0.1636 |
7295 | TXN | GSM4909311 | Human | Breast | IDC | 2.73e-46 | -5.31e-01 | 0.1534 |
7295 | TXN | GSM4909312 | Human | Breast | IDC | 1.04e-03 | -1.55e-01 | 0.1552 |
7295 | TXN | GSM4909313 | Human | Breast | IDC | 2.49e-11 | -4.70e-01 | 0.0391 |
7295 | TXN | GSM4909315 | Human | Breast | IDC | 4.25e-04 | 1.60e-01 | 0.21 |
7295 | TXN | GSM4909316 | Human | Breast | IDC | 1.49e-06 | 3.43e-02 | 0.21 |
7295 | TXN | GSM4909317 | Human | Breast | IDC | 4.83e-05 | -2.42e-01 | 0.1355 |
7295 | TXN | GSM4909319 | Human | Breast | IDC | 5.26e-74 | -9.89e-01 | 0.1563 |
7295 | TXN | GSM4909320 | Human | Breast | IDC | 1.62e-11 | -6.48e-01 | 0.1575 |
7295 | TXN | GSM4909321 | Human | Breast | IDC | 7.70e-08 | -2.26e-01 | 0.1559 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005123513 | Breast | IDC | maintenance of location | 48/1434 | 327/18723 | 9.90e-06 | 2.77e-04 | 48 |
GO:000941013 | Breast | IDC | response to xenobiotic stimulus | 62/1434 | 462/18723 | 1.05e-05 | 2.88e-04 | 62 |
GO:190165414 | Breast | IDC | response to ketone | 33/1434 | 194/18723 | 1.17e-05 | 3.13e-04 | 33 |
GO:003428414 | Breast | IDC | response to monosaccharide | 36/1434 | 225/18723 | 1.94e-05 | 4.83e-04 | 36 |
GO:005109914 | Breast | IDC | positive regulation of binding | 30/1434 | 173/18723 | 1.96e-05 | 4.86e-04 | 30 |
GO:199074813 | Breast | IDC | cellular detoxification | 23/1434 | 116/18723 | 2.02e-05 | 4.92e-04 | 23 |
GO:009723713 | Breast | IDC | cellular response to toxic substance | 24/1434 | 124/18723 | 2.05e-05 | 4.97e-04 | 24 |
GO:003250714 | Breast | IDC | maintenance of protein location in cell | 16/1434 | 65/18723 | 2.29e-05 | 5.51e-04 | 16 |
GO:000961211 | Breast | IDC | response to mechanical stimulus | 34/1434 | 216/18723 | 4.59e-05 | 1.03e-03 | 34 |
GO:000974314 | Breast | IDC | response to carbohydrate | 38/1434 | 253/18723 | 4.87e-05 | 1.07e-03 | 38 |
GO:007259512 | Breast | IDC | maintenance of protein localization in organelle | 12/1434 | 42/18723 | 4.94e-05 | 1.08e-03 | 12 |
GO:004338812 | Breast | IDC | positive regulation of DNA binding | 14/1434 | 56/18723 | 6.11e-05 | 1.27e-03 | 14 |
GO:007135613 | Breast | IDC | cellular response to tumor necrosis factor | 35/1434 | 229/18723 | 6.64e-05 | 1.35e-03 | 35 |
GO:000974613 | Breast | IDC | response to hexose | 33/1434 | 219/18723 | 1.39e-04 | 2.49e-03 | 33 |
GO:003461213 | Breast | IDC | response to tumor necrosis factor | 36/1434 | 253/18723 | 2.29e-04 | 3.64e-03 | 36 |
GO:003461413 | Breast | IDC | cellular response to reactive oxygen species | 25/1434 | 155/18723 | 3.03e-04 | 4.57e-03 | 25 |
GO:000974913 | Breast | IDC | response to glucose | 31/1434 | 212/18723 | 3.75e-04 | 5.35e-03 | 31 |
GO:190320114 | Breast | IDC | regulation of oxidative stress-induced cell death | 15/1434 | 74/18723 | 4.18e-04 | 5.74e-03 | 15 |
GO:007259413 | Breast | IDC | establishment of protein localization to organelle | 51/1434 | 422/18723 | 7.94e-04 | 9.55e-03 | 51 |
GO:000854412 | Breast | IDC | epidermis development | 41/1434 | 324/18723 | 1.03e-03 | 1.14e-02 | 41 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501218 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0513218 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0541818 | Breast | Precancer | Fluid shear stress and atherosclerosis | 28/684 | 139/8465 | 4.74e-06 | 6.00e-05 | 4.59e-05 | 28 |
hsa0501219 | Breast | Precancer | Parkinson disease | 99/684 | 266/8465 | 3.58e-42 | 5.65e-40 | 4.33e-40 | 99 |
hsa0513219 | Breast | Precancer | Salmonella infection | 49/684 | 249/8465 | 2.92e-09 | 6.15e-08 | 4.71e-08 | 49 |
hsa0541819 | Breast | Precancer | Fluid shear stress and atherosclerosis | 28/684 | 139/8465 | 4.74e-06 | 6.00e-05 | 4.59e-05 | 28 |
hsa0501224 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0513224 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0541824 | Breast | IDC | Fluid shear stress and atherosclerosis | 34/867 | 139/8465 | 9.41e-07 | 1.61e-05 | 1.20e-05 | 34 |
hsa0501234 | Breast | IDC | Parkinson disease | 107/867 | 266/8465 | 2.57e-39 | 8.36e-37 | 6.26e-37 | 107 |
hsa0513234 | Breast | IDC | Salmonella infection | 55/867 | 249/8465 | 2.07e-08 | 4.49e-07 | 3.36e-07 | 55 |
hsa0541834 | Breast | IDC | Fluid shear stress and atherosclerosis | 34/867 | 139/8465 | 9.41e-07 | 1.61e-05 | 1.20e-05 | 34 |
hsa0501243 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0513243 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0541844 | Breast | DCIS | Fluid shear stress and atherosclerosis | 34/846 | 139/8465 | 5.31e-07 | 9.03e-06 | 6.65e-06 | 34 |
hsa0501253 | Breast | DCIS | Parkinson disease | 106/846 | 266/8465 | 1.64e-39 | 5.29e-37 | 3.90e-37 | 106 |
hsa0513253 | Breast | DCIS | Salmonella infection | 55/846 | 249/8465 | 8.71e-09 | 1.87e-07 | 1.38e-07 | 55 |
hsa0541854 | Breast | DCIS | Fluid shear stress and atherosclerosis | 34/846 | 139/8465 | 5.31e-07 | 9.03e-06 | 6.65e-06 | 34 |
hsa0501220 | Cervix | CC | Parkinson disease | 102/1267 | 266/8465 | 1.81e-21 | 1.47e-19 | 8.66e-20 | 102 |
hsa0541820 | Cervix | CC | Fluid shear stress and atherosclerosis | 50/1267 | 139/8465 | 5.71e-10 | 1.32e-08 | 7.81e-09 | 50 |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TXN | SNV | Missense_Mutation | novel | c.292G>A | p.Glu98Lys | p.E98K | P10599 | protein_coding | tolerated(0.18) | probably_damaging(1) | TCGA-BH-A0HK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
TXN | SNV | Missense_Mutation | rs547387406 | c.89N>T | p.Thr30Met | p.T30M | P10599 | protein_coding | tolerated(0.08) | possibly_damaging(0.464) | TCGA-CN-5361-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
TXN | SNV | Missense_Mutation | c.74T>C | p.Val25Ala | p.V25A | P10599 | protein_coding | tolerated(0.05) | benign(0.156) | TCGA-BR-8591-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
7295 | TXN | DRUGGABLE GENOME, THIOREDOXIN | GAMBOGIC ACID | GAMBOGIC ACID | 22663155 | |
7295 | TXN | DRUGGABLE GENOME, THIOREDOXIN | GAMBOGENIC ACID | GAMBOGENIC ACID | 22663155 | |
7295 | TXN | DRUGGABLE GENOME, THIOREDOXIN | BIOTINYLATED GAMBOGIC ACID | BIOTINYLATED GAMBOGIC ACID | 22663155 | |
7295 | TXN | DRUGGABLE GENOME, THIOREDOXIN | PX-12 | PX-12 | ||
7295 | TXN | DRUGGABLE GENOME, THIOREDOXIN | PX-12 | PX-12 |
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