Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/TRAPPC12_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/TRAPPC12_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/TRAPPC12_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/TRAPPC12_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/TRAPPC12_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/TRAPPC12_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00513104 | Skin | cSCC | metaphase plate congression | 41/4864 | 65/18723 | 3.34e-10 | 1.37e-08 | 41 |
GO:004325429 | Skin | cSCC | regulation of protein-containing complex assembly | 167/4864 | 428/18723 | 1.60e-09 | 5.97e-08 | 167 |
GO:00345025 | Skin | cSCC | protein localization to chromosome | 44/4864 | 92/18723 | 5.27e-06 | 7.64e-05 | 44 |
GO:00070309 | Skin | cSCC | Golgi organization | 64/4864 | 157/18723 | 3.53e-05 | 3.83e-04 | 64 |
GO:00513832 | Skin | cSCC | kinetochore organization | 15/4864 | 23/18723 | 8.72e-05 | 8.21e-04 | 15 |
GO:190211515 | Skin | cSCC | regulation of organelle assembly | 72/4864 | 186/18723 | 8.90e-05 | 8.35e-04 | 72 |
GO:00718241 | Skin | cSCC | protein-DNA complex subunit organization | 87/4864 | 241/18723 | 3.09e-04 | 2.47e-03 | 87 |
GO:00345082 | Skin | cSCC | centromere complex assembly | 16/4864 | 30/18723 | 1.27e-03 | 8.19e-03 | 16 |
GO:00513822 | Skin | cSCC | kinetochore assembly | 11/4864 | 18/18723 | 1.74e-03 | 1.06e-02 | 11 |
GO:00714592 | Skin | cSCC | protein localization to chromosome, centromeric region | 13/4864 | 25/18723 | 4.81e-03 | 2.44e-02 | 13 |
GO:004819320 | Thyroid | PTC | Golgi vesicle transport | 186/5968 | 296/18723 | 3.09e-28 | 1.22e-25 | 186 |
GO:1903829113 | Thyroid | PTC | positive regulation of cellular protein localization | 162/5968 | 276/18723 | 2.40e-20 | 3.52e-18 | 162 |
GO:0043254113 | Thyroid | PTC | regulation of protein-containing complex assembly | 215/5968 | 428/18723 | 1.23e-15 | 9.09e-14 | 215 |
GO:000688817 | Thyroid | PTC | endoplasmic reticulum to Golgi vesicle-mediated transport | 83/5968 | 130/18723 | 6.19e-14 | 3.52e-12 | 83 |
GO:005165620 | Thyroid | PTC | establishment of organelle localization | 193/5968 | 390/18723 | 2.21e-13 | 1.15e-11 | 193 |
GO:003304419 | Thyroid | PTC | regulation of chromosome organization | 102/5968 | 187/18723 | 1.04e-10 | 3.58e-09 | 102 |
GO:000703010 | Thyroid | PTC | Golgi organization | 79/5968 | 157/18723 | 1.11e-06 | 1.64e-05 | 79 |
GO:190211516 | Thyroid | PTC | regulation of organelle assembly | 88/5968 | 186/18723 | 7.41e-06 | 8.65e-05 | 88 |
GO:00070595 | Thyroid | PTC | chromosome segregation | 146/5968 | 346/18723 | 2.99e-05 | 2.87e-04 | 146 |
GO:00988135 | Thyroid | PTC | nuclear chromosome segregation | 114/5968 | 281/18723 | 1.21e-03 | 6.94e-03 | 114 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TRAPPC12 | SNV | Missense_Mutation | novel | c.997G>A | p.Val333Met | p.V333M | Q8WVT3 | protein_coding | tolerated(0.06) | possibly_damaging(0.584) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
TRAPPC12 | SNV | Missense_Mutation | | c.2104N>A | p.Glu702Lys | p.E702K | Q8WVT3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-E2-A10C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
TRAPPC12 | insertion | Nonsense_Mutation | novel | c.1936_1937insCTCCATCTAAAAAATAAAAATAAATAAAAAC | p.Ile646ThrfsTer6 | p.I646Tfs*6 | Q8WVT3 | protein_coding | | | TCGA-A8-A0A1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
TRAPPC12 | deletion | Frame_Shift_Del | novel | c.1384_1387delNNNN | p.Glu462ThrfsTer42 | p.E462Tfs*42 | Q8WVT3 | protein_coding | | | TCGA-JL-A3YW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
TRAPPC12 | SNV | Missense_Mutation | novel | c.164C>T | p.Ser55Leu | p.S55L | Q8WVT3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRAPPC12 | SNV | Missense_Mutation | novel | c.628T>C | p.Phe210Leu | p.F210L | Q8WVT3 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.932) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
TRAPPC12 | SNV | Missense_Mutation | | c.1819G>A | p.Glu607Lys | p.E607K | Q8WVT3 | protein_coding | deleterious(0.04) | possibly_damaging(0.882) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
TRAPPC12 | SNV | Missense_Mutation | | c.1331N>T | p.Ala444Val | p.A444V | Q8WVT3 | protein_coding | tolerated(0.05) | probably_damaging(0.917) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRAPPC12 | SNV | Missense_Mutation | novel | c.1872N>A | p.Met624Ile | p.M624I | Q8WVT3 | protein_coding | tolerated(0.17) | benign(0.376) | TCGA-VS-A9UB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TRAPPC12 | SNV | Missense_Mutation | rs368315810 | c.1204N>T | p.Arg402Cys | p.R402C | Q8WVT3 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A6-6781-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |