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Gene: TNPO1 |
Gene summary for TNPO1 |
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Gene information | Species | Human | Gene symbol | TNPO1 | Gene ID | 3842 |
Gene name | transportin 1 | |
Gene Alias | IPO2 | |
Cytomap | 5q13.2 | |
Gene Type | protein-coding | GO ID | GO:0006606 | UniProtAcc | A0A024RAM0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3842 | TNPO1 | CCI_2 | Human | Cervix | CC | 3.41e-02 | 6.73e-01 | 0.5249 |
3842 | TNPO1 | CCI_3 | Human | Cervix | CC | 1.39e-02 | 5.18e-01 | 0.516 |
3842 | TNPO1 | LZE2T | Human | Esophagus | ESCC | 6.36e-06 | 6.63e-01 | 0.082 |
3842 | TNPO1 | LZE4T | Human | Esophagus | ESCC | 8.20e-13 | 8.11e-01 | 0.0811 |
3842 | TNPO1 | LZE5T | Human | Esophagus | ESCC | 1.88e-07 | -1.53e-02 | 0.0514 |
3842 | TNPO1 | LZE7T | Human | Esophagus | ESCC | 4.37e-05 | 5.07e-01 | 0.0667 |
3842 | TNPO1 | LZE8T | Human | Esophagus | ESCC | 1.21e-15 | 5.00e-02 | 0.067 |
3842 | TNPO1 | LZE20T | Human | Esophagus | ESCC | 2.80e-05 | 4.51e-02 | 0.0662 |
3842 | TNPO1 | LZE24T | Human | Esophagus | ESCC | 8.97e-16 | 3.36e-01 | 0.0596 |
3842 | TNPO1 | LZE21T | Human | Esophagus | ESCC | 3.91e-03 | 2.42e-01 | 0.0655 |
3842 | TNPO1 | LZE6T | Human | Esophagus | ESCC | 2.57e-10 | 1.16e-01 | 0.0845 |
3842 | TNPO1 | P1T-E | Human | Esophagus | ESCC | 3.53e-12 | 1.97e-01 | 0.0875 |
3842 | TNPO1 | P2T-E | Human | Esophagus | ESCC | 6.87e-48 | 8.58e-01 | 0.1177 |
3842 | TNPO1 | P4T-E | Human | Esophagus | ESCC | 1.35e-21 | 3.33e-01 | 0.1323 |
3842 | TNPO1 | P5T-E | Human | Esophagus | ESCC | 1.92e-16 | 3.27e-02 | 0.1327 |
3842 | TNPO1 | P8T-E | Human | Esophagus | ESCC | 1.05e-22 | 2.10e-01 | 0.0889 |
3842 | TNPO1 | P9T-E | Human | Esophagus | ESCC | 3.09e-15 | 4.45e-01 | 0.1131 |
3842 | TNPO1 | P10T-E | Human | Esophagus | ESCC | 8.58e-22 | 4.39e-01 | 0.116 |
3842 | TNPO1 | P11T-E | Human | Esophagus | ESCC | 1.70e-10 | 2.36e-01 | 0.1426 |
3842 | TNPO1 | P12T-E | Human | Esophagus | ESCC | 2.20e-21 | 4.63e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003450423 | Thyroid | ATC | protein localization to nucleus | 175/6293 | 290/18723 | 6.23e-21 | 1.23e-18 | 175 |
GO:000691326 | Thyroid | ATC | nucleocytoplasmic transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
GO:005116926 | Thyroid | ATC | nuclear transport | 180/6293 | 301/18723 | 6.97e-21 | 1.30e-18 | 180 |
GO:001703822 | Thyroid | ATC | protein import | 110/6293 | 206/18723 | 3.49e-09 | 8.09e-08 | 110 |
GO:005117018 | Thyroid | ATC | import into nucleus | 86/6293 | 159/18723 | 8.02e-08 | 1.40e-06 | 86 |
GO:000660617 | Thyroid | ATC | protein import into nucleus | 83/6293 | 155/18723 | 2.38e-07 | 3.70e-06 | 83 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301321 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa0301331 | Esophagus | ESCC | Nucleocytoplasmic transport | 89/4205 | 108/8465 | 1.20e-12 | 2.37e-11 | 1.21e-11 | 89 |
hsa03013 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030131 | Liver | HCC | Nucleocytoplasmic transport | 81/4020 | 108/8465 | 4.28e-09 | 6.83e-08 | 3.80e-08 | 81 |
hsa030136 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa0301311 | Oral cavity | OSCC | Nucleocytoplasmic transport | 82/3704 | 108/8465 | 7.93e-12 | 1.33e-10 | 6.77e-11 | 82 |
hsa030132 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
hsa030133 | Oral cavity | LP | Nucleocytoplasmic transport | 53/2418 | 108/8465 | 4.68e-06 | 4.10e-05 | 2.64e-05 | 53 |
hsa030134 | Oral cavity | EOLP | Nucleocytoplasmic transport | 34/1218 | 108/8465 | 4.24e-06 | 2.91e-05 | 1.72e-05 | 34 |
hsa030135 | Oral cavity | EOLP | Nucleocytoplasmic transport | 34/1218 | 108/8465 | 4.24e-06 | 2.91e-05 | 1.72e-05 | 34 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TNPO1 | SNV | Missense_Mutation | c.2501N>C | p.Ser834Thr | p.S834T | Q92973 | protein_coding | tolerated(0.1) | benign(0) | TCGA-A8-A085-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
TNPO1 | SNV | Missense_Mutation | c.1960N>C | p.Asp654His | p.D654H | Q92973 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
TNPO1 | SNV | Missense_Mutation | novel | c.2659N>T | p.Pro887Ser | p.P887S | Q92973 | protein_coding | tolerated(0.87) | benign(0.003) | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TNPO1 | SNV | Missense_Mutation | c.2484N>T | p.Met828Ile | p.M828I | Q92973 | protein_coding | deleterious(0.01) | benign(0.034) | TCGA-FU-A40J-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | carboplatin | CR | |
TNPO1 | SNV | Missense_Mutation | c.895G>C | p.Asp299His | p.D299H | Q92973 | protein_coding | deleterious(0.05) | benign(0.006) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
TNPO1 | SNV | Missense_Mutation | novel | c.1799N>T | p.Ser600Leu | p.S600L | Q92973 | protein_coding | deleterious(0) | possibly_damaging(0.801) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
TNPO1 | SNV | Missense_Mutation | novel | c.2563G>C | p.Asp855His | p.D855H | Q92973 | protein_coding | tolerated(0.09) | benign(0.109) | TCGA-VS-A9UH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
TNPO1 | SNV | Missense_Mutation | c.2671N>T | p.Arg891Cys | p.R891C | Q92973 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TNPO1 | SNV | Missense_Mutation | novel | c.1411A>G | p.Ser471Gly | p.S471G | Q92973 | protein_coding | tolerated(0.82) | benign(0.102) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
TNPO1 | SNV | Missense_Mutation | c.1723N>T | p.Pro575Ser | p.P575S | Q92973 | protein_coding | deleterious(0) | possibly_damaging(0.686) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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