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Gene: TIAM1 |
Gene summary for TIAM1 |
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Gene information | Species | Human | Gene symbol | TIAM1 | Gene ID | 7074 |
Gene name | TIAM Rac1 associated GEF 1 | |
Gene Alias | TIAM-1 | |
Cytomap | 21q22.11 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q13009 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7074 | TIAM1 | CCI_1 | Human | Cervix | CC | 6.22e-17 | 1.56e+00 | 0.528 |
7074 | TIAM1 | CCI_2 | Human | Cervix | CC | 1.25e-05 | 9.57e-01 | 0.5249 |
7074 | TIAM1 | CCI_3 | Human | Cervix | CC | 2.01e-07 | 7.55e-01 | 0.516 |
7074 | TIAM1 | AEH-subject2 | Human | Endometrium | AEH | 2.67e-03 | 1.57e-01 | -0.2525 |
7074 | TIAM1 | AEH-subject4 | Human | Endometrium | AEH | 7.66e-11 | 4.04e-01 | -0.2657 |
7074 | TIAM1 | AEH-subject5 | Human | Endometrium | AEH | 3.46e-33 | 7.75e-01 | -0.2953 |
7074 | TIAM1 | EEC-subject2 | Human | Endometrium | EEC | 1.59e-10 | 3.41e-01 | -0.2607 |
7074 | TIAM1 | P2T-E | Human | Esophagus | ESCC | 1.20e-14 | 6.68e-02 | 0.1177 |
7074 | TIAM1 | P4T-E | Human | Esophagus | ESCC | 4.06e-04 | 1.12e-01 | 0.1323 |
7074 | TIAM1 | P5T-E | Human | Esophagus | ESCC | 3.41e-07 | 1.05e-02 | 0.1327 |
7074 | TIAM1 | P8T-E | Human | Esophagus | ESCC | 7.87e-05 | -2.35e-02 | 0.0889 |
7074 | TIAM1 | P9T-E | Human | Esophagus | ESCC | 3.79e-04 | 7.92e-02 | 0.1131 |
7074 | TIAM1 | P10T-E | Human | Esophagus | ESCC | 1.07e-49 | 8.69e-01 | 0.116 |
7074 | TIAM1 | P11T-E | Human | Esophagus | ESCC | 5.58e-03 | 9.96e-02 | 0.1426 |
7074 | TIAM1 | P12T-E | Human | Esophagus | ESCC | 3.03e-05 | 6.09e-02 | 0.1122 |
7074 | TIAM1 | P15T-E | Human | Esophagus | ESCC | 8.37e-03 | 1.77e-02 | 0.1149 |
7074 | TIAM1 | P16T-E | Human | Esophagus | ESCC | 5.86e-04 | 2.00e-02 | 0.1153 |
7074 | TIAM1 | P21T-E | Human | Esophagus | ESCC | 3.49e-03 | -7.68e-02 | 0.1617 |
7074 | TIAM1 | P22T-E | Human | Esophagus | ESCC | 3.39e-08 | -4.21e-02 | 0.1236 |
7074 | TIAM1 | P23T-E | Human | Esophagus | ESCC | 2.06e-05 | 1.88e-01 | 0.108 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:005109816 | Endometrium | AEH | regulation of binding | 77/2100 | 363/18723 | 2.21e-08 | 1.31e-06 | 77 |
GO:001076910 | Endometrium | AEH | regulation of cell morphogenesis involved in differentiation | 31/2100 | 96/18723 | 2.70e-08 | 1.56e-06 | 31 |
GO:00301118 | Endometrium | AEH | regulation of Wnt signaling pathway | 71/2100 | 328/18723 | 3.31e-08 | 1.87e-06 | 71 |
GO:000974910 | Endometrium | AEH | response to glucose | 52/2100 | 212/18723 | 3.40e-08 | 1.91e-06 | 52 |
GO:00160499 | Endometrium | AEH | cell growth | 93/2100 | 482/18723 | 1.00e-07 | 4.99e-06 | 93 |
GO:00016789 | Endometrium | AEH | cellular glucose homeostasis | 44/2100 | 172/18723 | 1.04e-07 | 5.07e-06 | 44 |
GO:00071609 | Endometrium | AEH | cell-matrix adhesion | 54/2100 | 233/18723 | 1.42e-07 | 6.37e-06 | 54 |
GO:00605607 | Endometrium | AEH | developmental growth involved in morphogenesis | 53/2100 | 234/18723 | 4.02e-07 | 1.67e-05 | 53 |
GO:007132210 | Endometrium | AEH | cellular response to carbohydrate stimulus | 41/2100 | 163/18723 | 4.55e-07 | 1.87e-05 | 41 |
GO:00160558 | Endometrium | AEH | Wnt signaling pathway | 85/2100 | 444/18723 | 4.99e-07 | 1.97e-05 | 85 |
GO:00074098 | Endometrium | AEH | axonogenesis | 81/2100 | 418/18723 | 5.54e-07 | 2.12e-05 | 81 |
GO:01987388 | Endometrium | AEH | cell-cell signaling by wnt | 85/2100 | 446/18723 | 6.07e-07 | 2.29e-05 | 85 |
GO:00615648 | Endometrium | AEH | axon development | 88/2100 | 467/18723 | 6.39e-07 | 2.38e-05 | 88 |
GO:00713339 | Endometrium | AEH | cellular response to glucose stimulus | 38/2100 | 151/18723 | 1.17e-06 | 3.82e-05 | 38 |
GO:00713319 | Endometrium | AEH | cellular response to hexose stimulus | 38/2100 | 153/18723 | 1.65e-06 | 5.13e-05 | 38 |
GO:004259310 | Endometrium | AEH | glucose homeostasis | 55/2100 | 258/18723 | 1.87e-06 | 5.74e-05 | 55 |
GO:00713269 | Endometrium | AEH | cellular response to monosaccharide stimulus | 38/2100 | 154/18723 | 1.96e-06 | 5.93e-05 | 38 |
GO:003350010 | Endometrium | AEH | carbohydrate homeostasis | 55/2100 | 259/18723 | 2.12e-06 | 6.31e-05 | 55 |
GO:005109916 | Endometrium | AEH | positive regulation of binding | 41/2100 | 173/18723 | 2.39e-06 | 6.92e-05 | 41 |
GO:00107709 | Endometrium | AEH | positive regulation of cell morphogenesis involved in differentiation | 24/2100 | 79/18723 | 3.33e-06 | 9.03e-05 | 24 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520516 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0481016 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa0453020 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0401512 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa040142 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa04062 | Cervix | CC | Chemokine signaling pathway | 43/1267 | 192/8465 | 3.60e-03 | 1.34e-02 | 7.91e-03 | 43 |
hsa0520517 | Cervix | CC | Proteoglycans in cancer | 60/1267 | 205/8465 | 9.13e-08 | 1.18e-06 | 7.00e-07 | 60 |
hsa0481017 | Cervix | CC | Regulation of actin cytoskeleton | 64/1267 | 229/8465 | 2.24e-07 | 2.59e-06 | 1.53e-06 | 64 |
hsa04530110 | Cervix | CC | Tight junction | 49/1267 | 169/8465 | 1.87e-06 | 1.78e-05 | 1.05e-05 | 49 |
hsa0401513 | Cervix | CC | Rap1 signaling pathway | 56/1267 | 210/8465 | 6.23e-06 | 5.61e-05 | 3.32e-05 | 56 |
hsa0401411 | Cervix | CC | Ras signaling pathway | 51/1267 | 236/8465 | 3.55e-03 | 1.34e-02 | 7.91e-03 | 51 |
hsa040621 | Cervix | CC | Chemokine signaling pathway | 43/1267 | 192/8465 | 3.60e-03 | 1.34e-02 | 7.91e-03 | 43 |
hsa0453026 | Endometrium | AEH | Tight junction | 54/1197 | 169/8465 | 1.99e-09 | 3.80e-08 | 2.78e-08 | 54 |
hsa0520518 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa0401514 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa0481018 | Endometrium | AEH | Regulation of actin cytoskeleton | 50/1197 | 229/8465 | 9.08e-04 | 5.78e-03 | 4.23e-03 | 50 |
hsa04530112 | Endometrium | AEH | Tight junction | 54/1197 | 169/8465 | 1.99e-09 | 3.80e-08 | 2.78e-08 | 54 |
hsa0520519 | Endometrium | AEH | Proteoglycans in cancer | 53/1197 | 205/8465 | 5.43e-06 | 6.53e-05 | 4.78e-05 | 53 |
hsa0401515 | Endometrium | AEH | Rap1 signaling pathway | 49/1197 | 210/8465 | 2.03e-04 | 1.78e-03 | 1.30e-03 | 49 |
hsa0481019 | Endometrium | AEH | Regulation of actin cytoskeleton | 50/1197 | 229/8465 | 9.08e-04 | 5.78e-03 | 4.23e-03 | 50 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
TIAM1 | SNV | Missense_Mutation | novel | c.58A>G | p.Ser20Gly | p.S20G | Q13009 | protein_coding | tolerated_low_confidence(0.52) | benign(0) | TCGA-A2-A4RW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
TIAM1 | SNV | Missense_Mutation | c.3413N>A | p.Arg1138His | p.R1138H | Q13009 | protein_coding | tolerated(0.84) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
TIAM1 | SNV | Missense_Mutation | novel | c.175N>G | p.Ser59Gly | p.S59G | Q13009 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.97) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
TIAM1 | SNV | Missense_Mutation | novel | c.845N>G | p.Pro282Arg | p.P282R | Q13009 | protein_coding | tolerated(0.39) | benign(0.024) | TCGA-GM-A3XL-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | fluorouracil | CR |
TIAM1 | SNV | Missense_Mutation | novel | c.1105N>A | p.Asp369Asn | p.D369N | Q13009 | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-PE-A5DC-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
TIAM1 | insertion | Frame_Shift_Ins | novel | c.1826_1827insTTATAGGCATGAGCCACCATGCCCAGCCTATTTTCTTT | p.Gln609HisfsTer14 | p.Q609Hfs*14 | Q13009 | protein_coding | TCGA-A7-A0CG-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
TIAM1 | insertion | Nonsense_Mutation | novel | c.2636_2637insCTGATTGAGCCCATTACCCTGGGGCTGGTG | p.Lys879delinsAsnTerLeuSerProLeuProTrpGlyTrpTrp | p.K879delinsN*LSPLPWGWW | Q13009 | protein_coding | TCGA-A8-A07U-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | SD | ||
TIAM1 | insertion | Nonsense_Mutation | novel | c.1972_1973insGGGAGAGAAGGGTAAGAAATAAGTAAACAATTAACTAGAC | p.Ser658TrpfsTer9 | p.S658Wfs*9 | Q13009 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
TIAM1 | deletion | Frame_Shift_Del | novel | c.1152delN | p.Tyr384Ter | p.Y384* | Q13009 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
TIAM1 | SNV | Missense_Mutation | c.4355N>A | p.Arg1452Gln | p.R1452Q | Q13009 | protein_coding | deleterious(0.05) | probably_damaging(0.994) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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