Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/STAT6_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/STAT6_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/STAT6_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/STAT6_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/STAT6_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/STAT6_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/STAT6_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/STAT6_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00487325 | Colorectum | CRC | gland development | 88/2078 | 436/18723 | 1.62e-08 | 2.79e-06 | 88 |
GO:00510545 | Colorectum | CRC | positive regulation of DNA metabolic process | 46/2078 | 201/18723 | 1.26e-06 | 7.21e-05 | 46 |
GO:00510525 | Colorectum | CRC | regulation of DNA metabolic process | 70/2078 | 359/18723 | 1.75e-06 | 8.92e-05 | 70 |
GO:00434344 | Colorectum | CRC | response to peptide hormone | 76/2078 | 414/18723 | 6.67e-06 | 2.56e-04 | 76 |
GO:00621975 | Colorectum | CRC | cellular response to chemical stress | 63/2078 | 337/18723 | 2.24e-05 | 6.49e-04 | 63 |
GO:00226124 | Colorectum | CRC | gland morphogenesis | 29/2078 | 118/18723 | 2.74e-05 | 7.49e-04 | 29 |
GO:00713754 | Colorectum | CRC | cellular response to peptide hormone stimulus | 55/2078 | 290/18723 | 4.82e-05 | 1.12e-03 | 55 |
GO:19016534 | Colorectum | CRC | cellular response to peptide | 64/2078 | 359/18723 | 8.54e-05 | 1.75e-03 | 64 |
GO:00345995 | Colorectum | CRC | cellular response to oxidative stress | 53/2078 | 288/18723 | 1.47e-04 | 2.68e-03 | 53 |
GO:00069795 | Colorectum | CRC | response to oxidative stress | 73/2078 | 446/18723 | 4.31e-04 | 6.34e-03 | 73 |
GO:00425425 | Colorectum | CRC | response to hydrogen peroxide | 30/2078 | 146/18723 | 6.12e-04 | 8.15e-03 | 30 |
GO:00003025 | Colorectum | CRC | response to reactive oxygen species | 41/2078 | 222/18723 | 7.28e-04 | 9.35e-03 | 41 |
GO:00506733 | Colorectum | CRC | epithelial cell proliferation | 69/2078 | 437/18723 | 1.61e-03 | 1.69e-02 | 69 |
GO:19021701 | Colorectum | CRC | cellular response to reactive nitrogen species | 7/2078 | 18/18723 | 2.16e-03 | 2.11e-02 | 7 |
GO:00016591 | Colorectum | CRC | temperature homeostasis | 32/2078 | 174/18723 | 2.81e-03 | 2.55e-02 | 32 |
GO:00308794 | Colorectum | CRC | mammary gland development | 26/2078 | 137/18723 | 4.32e-03 | 3.47e-02 | 26 |
GO:01061062 | Colorectum | CRC | cold-induced thermogenesis | 27/2078 | 144/18723 | 4.38e-03 | 3.47e-02 | 27 |
GO:01201612 | Colorectum | CRC | regulation of cold-induced thermogenesis | 27/2078 | 144/18723 | 4.38e-03 | 3.47e-02 | 27 |
GO:01201622 | Colorectum | CRC | positive regulation of cold-induced thermogenesis | 20/2078 | 97/18723 | 4.45e-03 | 3.48e-02 | 20 |
GO:00335982 | Colorectum | CRC | mammary gland epithelial cell proliferation | 8/2078 | 26/18723 | 5.65e-03 | 4.24e-02 | 8 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STAT6 | SNV | Missense_Mutation | novel | c.2233N>G | p.Leu745Val | p.L745V | P42226 | protein_coding | tolerated_low_confidence(0.13) | benign(0.055) | TCGA-3C-AALK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
STAT6 | SNV | Missense_Mutation | novel | c.85N>T | p.Leu29Phe | p.L29F | P42226 | protein_coding | tolerated(0.35) | benign(0.085) | TCGA-A2-A0CK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR |
STAT6 | SNV | Missense_Mutation | novel | c.257N>A | p.Ser86Asn | p.S86N | P42226 | protein_coding | tolerated(0.98) | benign(0.001) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STAT6 | SNV | Missense_Mutation | rs778871413 | c.173N>T | p.Ser58Leu | p.S58L | P42226 | protein_coding | deleterious(0.04) | possibly_damaging(0.498) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
STAT6 | SNV | Missense_Mutation | | c.737N>A | p.Gly246Asp | p.G246D | P42226 | protein_coding | tolerated(0.15) | benign(0.142) | TCGA-BH-A0B8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD |
STAT6 | SNV | Missense_Mutation | novel | c.1693N>A | p.Asp565Asn | p.D565N | P42226 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A1XF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin+cyclophosphamide | SD |
STAT6 | SNV | Missense_Mutation | | c.1864G>T | p.Asp622Tyr | p.D622Y | P42226 | protein_coding | deleterious(0) | possibly_damaging(0.67) | TCGA-EW-A1P4-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | docetaxel | SD |
STAT6 | deletion | Frame_Shift_Del | novel | c.398delN | p.Gly133AlafsTer9 | p.G133Afs*9 | P42226 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
STAT6 | SNV | Missense_Mutation | novel | c.1669N>A | p.Gly557Arg | p.G557R | P42226 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
STAT6 | SNV | Missense_Mutation | novel | c.2059N>T | p.Asp687Tyr | p.D687Y | P42226 | protein_coding | deleterious(0.03) | possibly_damaging(0.62) | TCGA-C5-A7XC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | NSC-607097 | CHEMBL1374370 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | GW7074 | CHEMBL72365 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | DOXORUBICIN HYDROCHLORIDE | DOXORUBICIN HYDROCHLORIDE | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | EOTAXIN | | 12576300 |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | GLUCOCORTICOID | | 15544592 |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | ELLIPTECINE | ELLIPTECINE | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | NSC-176327 | CHEMBL363332 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | NSC-119889 | CHEMBL516616 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | SU-6656 | CHEMBL605003 | |
6778 | STAT6 | TRANSCRIPTION FACTOR, KINASE, CLINICALLY ACTIONABLE, DRUGGABLE GENOME | | SANGUINARIUM | SANGUINARIUM | |