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Gene: STARD3 |
Gene summary for STARD3 |
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Gene information | Species | Human | Gene symbol | STARD3 | Gene ID | 10948 |
Gene name | StAR related lipid transfer domain containing 3 | |
Gene Alias | CAB1 | |
Cytomap | 17q12 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | Q14849 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10948 | STARD3 | GSM4909291 | Human | Breast | IDC | 3.20e-28 | 7.82e-01 | 0.1753 |
10948 | STARD3 | GSM4909292 | Human | Breast | IDC | 1.35e-13 | 9.25e-01 | 0.1236 |
10948 | STARD3 | GSM4909293 | Human | Breast | IDC | 8.68e-35 | 6.07e-01 | 0.1581 |
10948 | STARD3 | GSM4909294 | Human | Breast | IDC | 1.66e-02 | 2.35e-01 | 0.2022 |
10948 | STARD3 | GSM4909319 | Human | Breast | IDC | 9.90e-04 | -3.32e-02 | 0.1563 |
10948 | STARD3 | M2 | Human | Breast | IDC | 4.76e-18 | 1.00e+00 | 0.21 |
10948 | STARD3 | NCCBC14 | Human | Breast | DCIS | 2.15e-03 | 2.99e-01 | 0.2021 |
10948 | STARD3 | NCCBC5 | Human | Breast | DCIS | 1.72e-07 | 4.09e-01 | 0.2046 |
10948 | STARD3 | P2 | Human | Breast | IDC | 5.58e-07 | 4.57e-01 | 0.21 |
10948 | STARD3 | DCIS2 | Human | Breast | DCIS | 3.71e-13 | 2.94e-02 | 0.0085 |
10948 | STARD3 | LZE4T | Human | Esophagus | ESCC | 9.73e-12 | 2.22e-01 | 0.0811 |
10948 | STARD3 | LZE5T | Human | Esophagus | ESCC | 2.93e-02 | 2.12e-01 | 0.0514 |
10948 | STARD3 | LZE7T | Human | Esophagus | ESCC | 3.56e-07 | 6.05e-01 | 0.0667 |
10948 | STARD3 | LZE8T | Human | Esophagus | ESCC | 3.20e-04 | 2.29e-01 | 0.067 |
10948 | STARD3 | LZE20T | Human | Esophagus | ESCC | 4.47e-02 | 1.19e-01 | 0.0662 |
10948 | STARD3 | LZE22T | Human | Esophagus | ESCC | 2.36e-05 | 4.23e-01 | 0.068 |
10948 | STARD3 | LZE24T | Human | Esophagus | ESCC | 2.92e-24 | 7.11e-01 | 0.0596 |
10948 | STARD3 | LZE6T | Human | Esophagus | ESCC | 1.13e-04 | 4.10e-01 | 0.0845 |
10948 | STARD3 | P1T-E | Human | Esophagus | ESCC | 2.96e-09 | 4.73e-01 | 0.0875 |
10948 | STARD3 | P2T-E | Human | Esophagus | ESCC | 3.19e-29 | 4.53e-01 | 0.1177 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00990223 | Skin | cSCC | vesicle tethering | 8/4864 | 11/18723 | 1.56e-03 | 9.60e-03 | 8 |
GO:19026525 | Skin | cSCC | secondary alcohol metabolic process | 53/4864 | 147/18723 | 4.33e-03 | 2.27e-02 | 53 |
GO:000683928 | Thyroid | PTC | mitochondrial transport | 150/5968 | 254/18723 | 2.76e-19 | 3.34e-17 | 150 |
GO:005165620 | Thyroid | PTC | establishment of organelle localization | 193/5968 | 390/18723 | 2.21e-13 | 1.15e-11 | 193 |
GO:005165019 | Thyroid | PTC | establishment of vesicle localization | 89/5968 | 161/18723 | 6.38e-10 | 1.97e-08 | 89 |
GO:005164817 | Thyroid | PTC | vesicle localization | 94/5968 | 177/18723 | 3.54e-09 | 9.45e-08 | 94 |
GO:000690310 | Thyroid | PTC | vesicle targeting | 30/5968 | 45/18723 | 1.72e-06 | 2.39e-05 | 30 |
GO:00990224 | Thyroid | PTC | vesicle tethering | 8/5968 | 11/18723 | 6.50e-03 | 2.83e-02 | 8 |
GO:000683929 | Thyroid | ATC | mitochondrial transport | 151/6293 | 254/18723 | 2.07e-17 | 2.14e-15 | 151 |
GO:005165625 | Thyroid | ATC | establishment of organelle localization | 206/6293 | 390/18723 | 2.62e-15 | 1.84e-13 | 206 |
GO:0051650110 | Thyroid | ATC | establishment of vesicle localization | 87/6293 | 161/18723 | 7.16e-08 | 1.25e-06 | 87 |
GO:005164818 | Thyroid | ATC | vesicle localization | 91/6293 | 177/18723 | 7.21e-07 | 9.64e-06 | 91 |
GO:000690315 | Thyroid | ATC | vesicle targeting | 30/6293 | 45/18723 | 5.89e-06 | 6.18e-05 | 30 |
GO:009902211 | Thyroid | ATC | vesicle tethering | 8/6293 | 11/18723 | 9.31e-03 | 3.44e-02 | 8 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa049794 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
hsa049795 | Liver | HCC | Cholesterol metabolism | 41/4020 | 51/8465 | 1.33e-06 | 1.35e-05 | 7.49e-06 | 41 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STARD3 | SNV | Missense_Mutation | novel | c.1307N>G | p.Gln436Arg | p.Q436R | Q14849 | protein_coding | deleterious(0.03) | benign(0.007) | TCGA-AC-A62Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STARD3 | SNV | Missense_Mutation | c.140C>T | p.Ser47Phe | p.S47F | Q14849 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
STARD3 | insertion | Frame_Shift_Ins | novel | c.1308_1309insGGGCCTCCCCTTTGTCAGCCACCTTT | p.Arg437GlyfsTer67 | p.R437Gfs*67 | Q14849 | protein_coding | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | ||
STARD3 | insertion | In_Frame_Ins | novel | c.906_907insGTA | p.Leu302_Gln303insVal | p.L302_Q303insV | Q14849 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
STARD3 | insertion | Nonsense_Mutation | novel | c.908_909insCCATTGAAGTTCCCTTTCACGGCAAGACGTTTATCCTGAA | p.Gln303HisfsTer3 | p.Q303Hfs*3 | Q14849 | protein_coding | TCGA-BH-A0EE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | SD | ||
STARD3 | deletion | Frame_Shift_Del | novel | c.12delN | p.Arg6GlyfsTer3 | p.R6Gfs*3 | Q14849 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
STARD3 | deletion | Frame_Shift_Del | novel | c.583delN | p.Leu196CysfsTer90 | p.L196Cfs*90 | Q14849 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
STARD3 | SNV | Missense_Mutation | rs143167128 | c.1168N>A | p.Val390Met | p.V390M | Q14849 | protein_coding | tolerated(0.31) | probably_damaging(0.933) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
STARD3 | SNV | Missense_Mutation | c.658N>A | p.Glu220Lys | p.E220K | Q14849 | protein_coding | deleterious(0.03) | benign(0.092) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
STARD3 | SNV | Missense_Mutation | rs749828666 | c.1271N>T | p.Ala424Val | p.A424V | Q14849 | protein_coding | deleterious(0.01) | benign(0.339) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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