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Gene: STARD13 |
Gene summary for STARD13 |
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Gene information | Species | Human | Gene symbol | STARD13 | Gene ID | 90627 |
Gene name | StAR related lipid transfer domain containing 13 | |
Gene Alias | ARHGAP37 | |
Cytomap | 13q13.1-q13.2 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q9Y3M8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
90627 | STARD13 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.64e-25 | -7.27e-01 | 0.0155 |
90627 | STARD13 | HTA11_2487_2000001011 | Human | Colorectum | SER | 3.91e-12 | -6.76e-01 | -0.1808 |
90627 | STARD13 | HTA11_2951_2000001011 | Human | Colorectum | AD | 2.52e-03 | -6.88e-01 | 0.0216 |
90627 | STARD13 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.94e-03 | -5.73e-01 | -0.0811 |
90627 | STARD13 | HTA11_78_2000001011 | Human | Colorectum | AD | 6.92e-13 | -7.05e-01 | -0.1088 |
90627 | STARD13 | HTA11_3361_2000001011 | Human | Colorectum | AD | 2.83e-08 | -7.15e-01 | -0.1207 |
90627 | STARD13 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.64e-03 | -5.25e-01 | -0.1526 |
90627 | STARD13 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.61e-12 | -5.10e-01 | -0.1464 |
90627 | STARD13 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.93e-14 | -5.81e-01 | -0.1001 |
90627 | STARD13 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.85e-02 | -4.17e-01 | -0.059 |
90627 | STARD13 | HTA11_2992_2000001011 | Human | Colorectum | SER | 6.39e-06 | -7.85e-01 | -0.1706 |
90627 | STARD13 | HTA11_5212_2000001011 | Human | Colorectum | AD | 5.99e-07 | -7.87e-01 | -0.2061 |
90627 | STARD13 | HTA11_5216_2000001011 | Human | Colorectum | SER | 1.05e-03 | -6.35e-01 | -0.1462 |
90627 | STARD13 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.08e-03 | -5.26e-01 | -0.0179 |
90627 | STARD13 | HTA11_866_3004761011 | Human | Colorectum | AD | 6.81e-14 | -5.99e-01 | 0.096 |
90627 | STARD13 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.94e-11 | -6.95e-01 | 0.0338 |
90627 | STARD13 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.17e-12 | -5.26e-01 | 0.0674 |
90627 | STARD13 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 2.16e-03 | 8.83e-01 | 0.3487 |
90627 | STARD13 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.01e-03 | 6.44e-01 | 0.281 |
90627 | STARD13 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 3.95e-03 | 6.10e-01 | 0.3859 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00350236 | Endometrium | AEH | regulation of Rho protein signal transduction | 18/2100 | 86/18723 | 6.39e-03 | 3.79e-02 | 18 |
GO:000166716 | Endometrium | EEC | ameboidal-type cell migration | 91/2168 | 475/18723 | 7.87e-07 | 2.80e-05 | 91 |
GO:009013015 | Endometrium | EEC | tissue migration | 73/2168 | 365/18723 | 1.91e-06 | 5.78e-05 | 73 |
GO:009013215 | Endometrium | EEC | epithelium migration | 72/2168 | 360/18723 | 2.24e-06 | 6.59e-05 | 72 |
GO:001063115 | Endometrium | EEC | epithelial cell migration | 71/2168 | 357/18723 | 3.24e-06 | 8.85e-05 | 71 |
GO:200014613 | Endometrium | EEC | negative regulation of cell motility | 71/2168 | 359/18723 | 3.98e-06 | 1.04e-04 | 71 |
GO:005127113 | Endometrium | EEC | negative regulation of cellular component movement | 72/2168 | 367/18723 | 4.59e-06 | 1.15e-04 | 72 |
GO:001063215 | Endometrium | EEC | regulation of epithelial cell migration | 60/2168 | 292/18723 | 6.37e-06 | 1.52e-04 | 60 |
GO:005105612 | Endometrium | EEC | regulation of small GTPase mediated signal transduction | 61/2168 | 302/18723 | 9.42e-06 | 2.08e-04 | 61 |
GO:003033612 | Endometrium | EEC | negative regulation of cell migration | 67/2168 | 344/18723 | 1.24e-05 | 2.54e-04 | 67 |
GO:004001312 | Endometrium | EEC | negative regulation of locomotion | 74/2168 | 391/18723 | 1.28e-05 | 2.59e-04 | 74 |
GO:006056213 | Endometrium | EEC | epithelial tube morphogenesis | 64/2168 | 325/18723 | 1.35e-05 | 2.70e-04 | 64 |
GO:000726513 | Endometrium | EEC | Ras protein signal transduction | 64/2168 | 337/18723 | 4.31e-05 | 7.10e-04 | 64 |
GO:004354213 | Endometrium | EEC | endothelial cell migration | 55/2168 | 279/18723 | 5.12e-05 | 8.18e-04 | 55 |
GO:000315813 | Endometrium | EEC | endothelium development | 32/2168 | 136/18723 | 6.37e-05 | 9.48e-04 | 32 |
GO:001059412 | Endometrium | EEC | regulation of endothelial cell migration | 47/2168 | 232/18723 | 8.81e-05 | 1.25e-03 | 47 |
GO:000726613 | Endometrium | EEC | Rho protein signal transduction | 30/2168 | 137/18723 | 4.05e-04 | 4.31e-03 | 30 |
GO:004657813 | Endometrium | EEC | regulation of Ras protein signal transduction | 37/2168 | 189/18723 | 9.23e-04 | 8.32e-03 | 37 |
GO:003502313 | Endometrium | EEC | regulation of Rho protein signal transduction | 20/2168 | 86/18723 | 1.65e-03 | 1.29e-02 | 20 |
GO:004353411 | Endometrium | EEC | blood vessel endothelial cell migration | 33/2168 | 176/18723 | 3.48e-03 | 2.35e-02 | 33 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
STARD13 | SNV | Missense_Mutation | c.125G>C | p.Ser42Thr | p.S42T | Q9Y3M8 | protein_coding | tolerated(0.23) | benign(0.078) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
STARD13 | insertion | Nonsense_Mutation | novel | c.3128_3129insAAAATAACATTAAAGGAGACTTATGTGTTAACGCTTTGTTTCTGCTA | p.Gly1044LysfsTer2 | p.G1044Kfs*2 | Q9Y3M8 | protein_coding | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | ||
STARD13 | insertion | Frame_Shift_Ins | novel | c.3094_3095insACAGTATTTTATTCATTGTTATCTTGCCAATGGAAATAAAGTATGA | p.Leu1032HisfsTer21 | p.L1032Hfs*21 | Q9Y3M8 | protein_coding | TCGA-AR-A0TY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | PD | ||
STARD13 | SNV | Missense_Mutation | novel | c.3265N>G | p.Leu1089Val | p.L1089V | Q9Y3M8 | protein_coding | deleterious(0.02) | benign(0.127) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
STARD13 | SNV | Missense_Mutation | c.2775N>A | p.Phe925Leu | p.F925L | Q9Y3M8 | protein_coding | deleterious(0) | benign(0.387) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STARD13 | SNV | Missense_Mutation | c.3058A>G | p.Thr1020Ala | p.T1020A | Q9Y3M8 | protein_coding | deleterious(0.01) | possibly_damaging(0.674) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
STARD13 | SNV | Missense_Mutation | c.1243N>A | p.Leu415Ile | p.L415I | Q9Y3M8 | protein_coding | deleterious(0.01) | probably_damaging(0.946) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
STARD13 | SNV | Missense_Mutation | novel | c.3108N>G | p.His1036Gln | p.H1036Q | Q9Y3M8 | protein_coding | deleterious(0.01) | probably_damaging(0.932) | TCGA-AA-3980-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
STARD13 | SNV | Missense_Mutation | novel | c.461N>A | p.Ser154Tyr | p.S154Y | Q9Y3M8 | protein_coding | deleterious(0) | possibly_damaging(0.878) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
STARD13 | SNV | Missense_Mutation | c.1173N>T | p.Glu391Asp | p.E391D | Q9Y3M8 | protein_coding | tolerated(0.13) | benign(0.019) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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