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Gene: SPCS1 |
Gene summary for SPCS1 |
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Gene information | Species | Human | Gene symbol | SPCS1 | Gene ID | 28972 |
Gene name | signal peptidase complex subunit 1 | |
Gene Alias | HSPC033 | |
Cytomap | 3p21.1 | |
Gene Type | protein-coding | GO ID | GO:0006465 | UniProtAcc | Q9Y6A9 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
28972 | SPCS1 | CA_HPV_1 | Human | Cervix | CC | 1.46e-15 | -1.16e-01 | 0.0264 |
28972 | SPCS1 | CA_HPV_2 | Human | Cervix | CC | 9.63e-06 | -3.38e-01 | 0.0391 |
28972 | SPCS1 | CA_HPV_3 | Human | Cervix | CC | 1.93e-03 | -8.86e-03 | 0.0414 |
28972 | SPCS1 | CCI_1 | Human | Cervix | CC | 1.03e-20 | -9.76e-01 | 0.528 |
28972 | SPCS1 | CCI_2 | Human | Cervix | CC | 1.67e-06 | -6.94e-01 | 0.5249 |
28972 | SPCS1 | CCI_3 | Human | Cervix | CC | 1.03e-16 | -8.54e-01 | 0.516 |
28972 | SPCS1 | CCII_1 | Human | Cervix | CC | 1.46e-32 | -9.64e-01 | 0.3249 |
28972 | SPCS1 | Tumor | Human | Cervix | CC | 1.05e-10 | -3.99e-01 | 0.1241 |
28972 | SPCS1 | sample3 | Human | Cervix | CC | 1.77e-13 | -3.90e-01 | 0.1387 |
28972 | SPCS1 | L1 | Human | Cervix | CC | 2.24e-07 | -2.26e-01 | 0.0802 |
28972 | SPCS1 | T1 | Human | Cervix | CC | 6.86e-13 | -5.18e-01 | 0.0918 |
28972 | SPCS1 | T3 | Human | Cervix | CC | 6.62e-13 | -4.09e-01 | 0.1389 |
28972 | SPCS1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 8.48e-07 | 2.03e-01 | 0.0155 |
28972 | SPCS1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.98e-11 | 4.81e-01 | -0.1808 |
28972 | SPCS1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.05e-09 | 5.05e-01 | -0.0811 |
28972 | SPCS1 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.33e-07 | 3.25e-01 | -0.1088 |
28972 | SPCS1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.79e-21 | 4.73e-01 | -0.1954 |
28972 | SPCS1 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.94e-06 | 7.61e-01 | -0.2602 |
28972 | SPCS1 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.07e-05 | 3.52e-01 | -0.1207 |
28972 | SPCS1 | HTA11_83_2000001011 | Human | Colorectum | SER | 5.97e-08 | 3.52e-01 | -0.1526 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0072594110 | Esophagus | ESCC | establishment of protein localization to organelle | 311/8552 | 422/18723 | 3.02e-32 | 2.13e-29 | 311 |
GO:0016032111 | Esophagus | ESCC | viral process | 301/8552 | 415/18723 | 3.34e-29 | 1.32e-26 | 301 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:0019058111 | Esophagus | ESCC | viral life cycle | 226/8552 | 317/18723 | 1.17e-20 | 1.76e-18 | 226 |
GO:001908017 | Esophagus | ESCC | viral gene expression | 80/8552 | 94/18723 | 2.04e-15 | 1.28e-13 | 80 |
GO:005160418 | Esophagus | ESCC | protein maturation | 189/8552 | 294/18723 | 7.64e-11 | 2.39e-09 | 189 |
GO:001906815 | Esophagus | ESCC | virion assembly | 31/8552 | 35/18723 | 1.40e-07 | 2.25e-06 | 31 |
GO:007097218 | Esophagus | ESCC | protein localization to endoplasmic reticulum | 52/8552 | 74/18723 | 1.58e-05 | 1.42e-04 | 52 |
GO:001648514 | Esophagus | ESCC | protein processing | 134/8552 | 225/18723 | 1.81e-05 | 1.60e-04 | 134 |
GO:00190826 | Esophagus | ESCC | viral protein processing | 24/8552 | 29/18723 | 4.50e-05 | 3.55e-04 | 24 |
GO:000646516 | Esophagus | ESCC | signal peptide processing | 13/8552 | 14/18723 | 3.02e-04 | 1.81e-03 | 13 |
GO:007259915 | Esophagus | ESCC | establishment of protein localization to endoplasmic reticulum | 31/8552 | 46/18723 | 2.42e-03 | 1.06e-02 | 31 |
GO:004504715 | Esophagus | ESCC | protein targeting to ER | 28/8552 | 42/18723 | 4.90e-03 | 1.89e-02 | 28 |
GO:001603212 | Liver | Cirrhotic | viral process | 203/4634 | 415/18723 | 5.40e-27 | 3.76e-24 | 203 |
GO:007259412 | Liver | Cirrhotic | establishment of protein localization to organelle | 189/4634 | 422/18723 | 1.01e-19 | 2.45e-17 | 189 |
GO:00066057 | Liver | Cirrhotic | protein targeting | 148/4634 | 314/18723 | 3.86e-18 | 6.20e-16 | 148 |
GO:001905812 | Liver | Cirrhotic | viral life cycle | 148/4634 | 317/18723 | 1.12e-17 | 1.64e-15 | 148 |
GO:00709724 | Liver | Cirrhotic | protein localization to endoplasmic reticulum | 45/4634 | 74/18723 | 4.79e-11 | 2.73e-09 | 45 |
GO:001908011 | Liver | Cirrhotic | viral gene expression | 52/4634 | 94/18723 | 2.19e-10 | 1.08e-08 | 52 |
GO:00516046 | Liver | Cirrhotic | protein maturation | 121/4634 | 294/18723 | 3.54e-10 | 1.68e-08 | 121 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0306010 | Cervix | CC | Protein export | 10/1267 | 23/8465 | 9.64e-04 | 4.22e-03 | 2.49e-03 | 10 |
hsa0306013 | Cervix | CC | Protein export | 10/1267 | 23/8465 | 9.64e-04 | 4.22e-03 | 2.49e-03 | 10 |
hsa03060 | Colorectum | AD | Protein export | 14/2092 | 23/8465 | 2.43e-04 | 1.90e-03 | 1.21e-03 | 14 |
hsa030601 | Colorectum | AD | Protein export | 14/2092 | 23/8465 | 2.43e-04 | 1.90e-03 | 1.21e-03 | 14 |
hsa030602 | Colorectum | MSS | Protein export | 15/1875 | 23/8465 | 1.13e-05 | 1.26e-04 | 7.71e-05 | 15 |
hsa030603 | Colorectum | MSS | Protein export | 15/1875 | 23/8465 | 1.13e-05 | 1.26e-04 | 7.71e-05 | 15 |
hsa030604 | Colorectum | MSI-H | Protein export | 11/797 | 23/8465 | 2.26e-06 | 3.65e-05 | 3.06e-05 | 11 |
hsa030605 | Colorectum | MSI-H | Protein export | 11/797 | 23/8465 | 2.26e-06 | 3.65e-05 | 3.06e-05 | 11 |
hsa0306014 | Endometrium | AEH | Protein export | 11/1197 | 23/8465 | 1.14e-04 | 1.06e-03 | 7.73e-04 | 11 |
hsa0306015 | Endometrium | AEH | Protein export | 11/1197 | 23/8465 | 1.14e-04 | 1.06e-03 | 7.73e-04 | 11 |
hsa0306023 | Endometrium | EEC | Protein export | 11/1237 | 23/8465 | 1.54e-04 | 1.41e-03 | 1.05e-03 | 11 |
hsa0306033 | Endometrium | EEC | Protein export | 11/1237 | 23/8465 | 1.54e-04 | 1.41e-03 | 1.05e-03 | 11 |
hsa0306020 | Esophagus | HGIN | Protein export | 13/1383 | 23/8465 | 1.27e-05 | 1.80e-04 | 1.43e-04 | 13 |
hsa03060110 | Esophagus | HGIN | Protein export | 13/1383 | 23/8465 | 1.27e-05 | 1.80e-04 | 1.43e-04 | 13 |
hsa0306026 | Esophagus | ESCC | Protein export | 22/4205 | 23/8465 | 2.43e-06 | 1.43e-05 | 7.32e-06 | 22 |
hsa0306036 | Esophagus | ESCC | Protein export | 22/4205 | 23/8465 | 2.43e-06 | 1.43e-05 | 7.32e-06 | 22 |
hsa030608 | Liver | Cirrhotic | Protein export | 20/2530 | 23/8465 | 2.00e-08 | 3.51e-07 | 2.17e-07 | 20 |
hsa0306011 | Liver | Cirrhotic | Protein export | 20/2530 | 23/8465 | 2.00e-08 | 3.51e-07 | 2.17e-07 | 20 |
hsa0306021 | Liver | HCC | Protein export | 21/4020 | 23/8465 | 1.20e-05 | 8.53e-05 | 4.74e-05 | 21 |
hsa0306031 | Liver | HCC | Protein export | 21/4020 | 23/8465 | 1.20e-05 | 8.53e-05 | 4.74e-05 | 21 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SPCS1 | SNV | Missense_Mutation | c.157N>G | p.Arg53Gly | p.R53G | protein_coding | tolerated_low_confidence(0.2) | benign(0.228) | TCGA-MA-AA3Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
SPCS1 | insertion | Frame_Shift_Ins | rs754517312 | c.286_287insT | p.Ser98PhefsTer13 | p.S98Ffs*13 | protein_coding | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
SPCS1 | SNV | Missense_Mutation | novel | c.477N>C | p.Glu159Asp | p.E159D | protein_coding | tolerated(0.73) | benign(0.001) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
SPCS1 | SNV | Missense_Mutation | novel | c.479N>T | p.Arg160Ile | p.R160I | protein_coding | deleterious(0.01) | possibly_damaging(0.855) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPCS1 | SNV | Missense_Mutation | novel | c.210N>T | p.Glu70Asp | p.E70D | protein_coding | tolerated(0.21) | benign(0.001) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
SPCS1 | SNV | Missense_Mutation | c.181N>A | p.Cys61Ser | p.C61S | protein_coding | tolerated_low_confidence(0.41) | benign(0.017) | TCGA-D1-A15W-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | SD | ||
SPCS1 | insertion | Frame_Shift_Ins | rs754517312 | c.292dupT | p.Ser98PhefsTer13 | p.S98Ffs*13 | protein_coding | TCGA-77-A5G3-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
SPCS1 | deletion | Frame_Shift_Del | novel | c.366delN | p.Phe123LeufsTer7 | p.F123Lfs*7 | protein_coding | TCGA-94-8035-01 | Lung | lung squamous cell carcinoma | Male | <65 | I/II | Unspecific | Complete Response | ||||
SPCS1 | SNV | Missense_Mutation | c.125N>G | p.Leu42Arg | p.L42R | protein_coding | tolerated_low_confidence(0.33) | benign(0) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
SPCS1 | SNV | Missense_Mutation | c.412N>T | p.Arg138Cys | p.R138C | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BR-8363-01 | Stomach | stomach adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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