![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: SOD3 |
Gene summary for SOD3 |
![]() |
Gene information | Species | Human | Gene symbol | SOD3 | Gene ID | 6649 |
Gene name | superoxide dismutase 3 | |
Gene Alias | EC-SOD | |
Cytomap | 4p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000302 | UniProtAcc | A0A140VJU8 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6649 | SOD3 | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.31e-07 | 1.86e-01 | 0.0155 |
6649 | SOD3 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.68e-08 | 2.29e-01 | -0.1808 |
6649 | SOD3 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.06e-19 | 8.85e-01 | -0.0811 |
6649 | SOD3 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.35e-06 | 2.99e-01 | -0.1088 |
6649 | SOD3 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.86e-11 | 2.83e-01 | -0.1954 |
6649 | SOD3 | HTA11_411_2000001011 | Human | Colorectum | SER | 2.78e-05 | 3.19e-01 | -0.2602 |
6649 | SOD3 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.90e-02 | 3.25e-01 | -0.2196 |
6649 | SOD3 | HTA11_696_2000001011 | Human | Colorectum | AD | 7.85e-16 | 3.66e-01 | -0.1464 |
6649 | SOD3 | HTA11_866_2000001011 | Human | Colorectum | AD | 6.22e-04 | 2.08e-01 | -0.1001 |
6649 | SOD3 | HTA11_1391_2000001011 | Human | Colorectum | AD | 9.45e-06 | 1.57e-01 | -0.059 |
6649 | SOD3 | HTA11_2992_2000001011 | Human | Colorectum | SER | 2.31e-08 | 4.10e-01 | -0.1706 |
6649 | SOD3 | HTA11_546_2000001011 | Human | Colorectum | AD | 1.43e-09 | 3.34e-01 | -0.0842 |
6649 | SOD3 | HTA11_7862_2000001011 | Human | Colorectum | AD | 1.24e-02 | 1.48e-01 | -0.0179 |
6649 | SOD3 | HTA11_866_3004761011 | Human | Colorectum | AD | 1.67e-10 | 2.43e-01 | 0.096 |
6649 | SOD3 | HTA11_4255_2000001011 | Human | Colorectum | SER | 3.34e-04 | 3.23e-01 | 0.0446 |
6649 | SOD3 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.95e-07 | 2.95e-01 | 0.0528 |
6649 | SOD3 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.28e-04 | 1.71e-01 | 0.0338 |
6649 | SOD3 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.86e-09 | 3.48e-01 | 0.0112 |
6649 | SOD3 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.35e-57 | 1.96e+00 | 0.0588 |
6649 | SOD3 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 5.98e-12 | 6.98e-01 | 0.2585 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003461412 | Liver | HCC | cellular response to reactive oxygen species | 102/7958 | 155/18723 | 3.70e-09 | 9.89e-08 | 102 |
GO:001003822 | Liver | HCC | response to metal ion | 208/7958 | 373/18723 | 1.35e-07 | 2.56e-06 | 208 |
GO:000963622 | Liver | HCC | response to toxic substance | 153/7958 | 262/18723 | 1.37e-07 | 2.58e-06 | 153 |
GO:000166612 | Liver | HCC | response to hypoxia | 172/7958 | 307/18723 | 1.06e-06 | 1.59e-05 | 172 |
GO:003629312 | Liver | HCC | response to decreased oxygen levels | 179/7958 | 322/18723 | 1.29e-06 | 1.87e-05 | 179 |
GO:007048212 | Liver | HCC | response to oxygen levels | 191/7958 | 347/18723 | 1.42e-06 | 2.03e-05 | 191 |
GO:199074812 | Liver | HCC | cellular detoxification | 70/7958 | 116/18723 | 7.87e-05 | 7.02e-04 | 70 |
GO:009723712 | Liver | HCC | cellular response to toxic substance | 74/7958 | 124/18723 | 8.36e-05 | 7.36e-04 | 74 |
GO:009875412 | Liver | HCC | detoxification | 87/7958 | 152/18723 | 1.70e-04 | 1.35e-03 | 87 |
GO:009886912 | Liver | HCC | cellular oxidant detoxification | 59/7958 | 101/18723 | 9.00e-04 | 5.31e-03 | 59 |
GO:007259312 | Liver | HCC | reactive oxygen species metabolic process | 124/7958 | 239/18723 | 2.05e-03 | 1.04e-02 | 124 |
GO:000697920 | Oral cavity | OSCC | response to oxidative stress | 273/7305 | 446/18723 | 8.35e-22 | 1.65e-19 | 273 |
GO:006219720 | Oral cavity | OSCC | cellular response to chemical stress | 204/7305 | 337/18723 | 6.89e-16 | 5.19e-14 | 204 |
GO:000030220 | Oral cavity | OSCC | response to reactive oxygen species | 143/7305 | 222/18723 | 1.32e-14 | 7.88e-13 | 143 |
GO:003459920 | Oral cavity | OSCC | cellular response to oxidative stress | 173/7305 | 288/18723 | 2.90e-13 | 1.43e-11 | 173 |
GO:007048219 | Oral cavity | OSCC | response to oxygen levels | 200/7305 | 347/18723 | 1.17e-12 | 5.13e-11 | 200 |
GO:000166619 | Oral cavity | OSCC | response to hypoxia | 177/7305 | 307/18723 | 2.21e-11 | 7.50e-10 | 177 |
GO:003629319 | Oral cavity | OSCC | response to decreased oxygen levels | 182/7305 | 322/18723 | 1.14e-10 | 3.41e-09 | 182 |
GO:003461419 | Oral cavity | OSCC | cellular response to reactive oxygen species | 96/7305 | 155/18723 | 5.98e-09 | 1.27e-07 | 96 |
GO:001003820 | Oral cavity | OSCC | response to metal ion | 188/7305 | 373/18723 | 4.34e-06 | 5.00e-05 | 188 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SOD3 | SNV | Missense_Mutation | novel | c.698N>A | p.Arg233His | p.R233H | P08294 | protein_coding | tolerated(0.11) | benign(0.028) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SOD3 | SNV | Missense_Mutation | novel | c.78N>T | p.Glu26Asp | p.E26D | P08294 | protein_coding | tolerated(0.3) | benign(0.014) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD |
SOD3 | SNV | Missense_Mutation | novel | c.8N>T | p.Ala3Val | p.A3V | P08294 | protein_coding | tolerated_low_confidence(0.3) | benign(0.122) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SOD3 | SNV | Missense_Mutation | novel | c.323G>T | p.Ser108Ile | p.S108I | P08294 | protein_coding | tolerated(0.2) | benign(0.003) | TCGA-69-8255-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SOD3 | SNV | Missense_Mutation | novel | c.401N>T | p.Pro134Leu | p.P134L | P08294 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-NC-A5HT-01 | Lung | lung squamous cell carcinoma | Male | >=65 | III/IV | Chemotherapy | carboplatin | PR |
SOD3 | SNV | Missense_Mutation | novel | c.314N>T | p.Glu105Val | p.E105V | P08294 | protein_coding | tolerated(0.09) | benign(0.005) | TCGA-CV-A461-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SOD3 | SNV | Missense_Mutation | rs747381585 | c.394N>C | p.Tyr132His | p.Y132H | P08294 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-F7-A624-01 | Oral cavity | head & neck squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
SOD3 | SNV | Missense_Mutation | c.160G>A | p.Asp54Asn | p.D54N | P08294 | protein_coding | tolerated(0.25) | benign(0.001) | TCGA-CH-5751-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 10 | Hormone Therapy | bicalutamide | PD | |
SOD3 | SNV | Missense_Mutation | novel | c.64N>A | p.Glu22Lys | p.E22K | P08294 | protein_coding | tolerated(0.9) | benign(0.007) | TCGA-MX-A5UJ-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
Page: 1 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |