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Gene: SNU13 |
Gene summary for SNU13 |
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Gene information | Species | Human | Gene symbol | SNU13 | Gene ID | 4809 |
Gene name | small nuclear ribonucleoprotein 13 | |
Gene Alias | 15.5K | |
Cytomap | 22q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P55769 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4809 | SNU13 | GSM4909281 | Human | Breast | IDC | 5.08e-05 | 3.16e-01 | 0.21 |
4809 | SNU13 | GSM4909282 | Human | Breast | IDC | 5.23e-06 | 3.13e-01 | -0.0288 |
4809 | SNU13 | GSM4909288 | Human | Breast | IDC | 2.52e-06 | -1.48e-01 | 0.0988 |
4809 | SNU13 | GSM4909293 | Human | Breast | IDC | 1.94e-11 | -4.02e-01 | 0.1581 |
4809 | SNU13 | GSM4909294 | Human | Breast | IDC | 6.23e-08 | -9.14e-02 | 0.2022 |
4809 | SNU13 | GSM4909296 | Human | Breast | IDC | 1.52e-15 | 5.79e-02 | 0.1524 |
4809 | SNU13 | GSM4909297 | Human | Breast | IDC | 1.48e-34 | -2.18e-01 | 0.1517 |
4809 | SNU13 | GSM4909298 | Human | Breast | IDC | 9.83e-07 | -2.76e-01 | 0.1551 |
4809 | SNU13 | GSM4909302 | Human | Breast | IDC | 1.17e-05 | -3.50e-01 | 0.1545 |
4809 | SNU13 | GSM4909309 | Human | Breast | IDC | 1.62e-08 | -2.40e-01 | 0.0483 |
4809 | SNU13 | GSM4909311 | Human | Breast | IDC | 1.39e-55 | -1.58e-01 | 0.1534 |
4809 | SNU13 | GSM4909312 | Human | Breast | IDC | 1.74e-14 | 1.29e-02 | 0.1552 |
4809 | SNU13 | GSM4909313 | Human | Breast | IDC | 1.07e-06 | -2.56e-01 | 0.0391 |
4809 | SNU13 | GSM4909316 | Human | Breast | IDC | 4.21e-06 | 1.86e-01 | 0.21 |
4809 | SNU13 | GSM4909319 | Human | Breast | IDC | 7.24e-71 | -2.40e-01 | 0.1563 |
4809 | SNU13 | GSM4909320 | Human | Breast | IDC | 1.30e-10 | -3.28e-01 | 0.1575 |
4809 | SNU13 | GSM4909321 | Human | Breast | IDC | 2.16e-24 | -3.45e-01 | 0.1559 |
4809 | SNU13 | brca1 | Human | Breast | Precancer | 1.53e-06 | 3.49e-01 | -0.0338 |
4809 | SNU13 | brca2 | Human | Breast | Precancer | 5.61e-03 | 2.14e-01 | -0.024 |
4809 | SNU13 | M2 | Human | Breast | IDC | 1.94e-03 | -8.08e-02 | 0.21 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00226132 | Colorectum | MSS | ribonucleoprotein complex biogenesis | 144/3467 | 463/18723 | 2.76e-11 | 3.67e-09 | 144 |
GO:00422732 | Colorectum | MSS | ribosomal large subunit biogenesis | 28/3467 | 72/18723 | 4.16e-05 | 7.83e-04 | 28 |
GO:00422542 | Colorectum | MSS | ribosome biogenesis | 79/3467 | 299/18723 | 4.32e-04 | 5.23e-03 | 79 |
GO:0000470 | Colorectum | MSS | maturation of LSU-rRNA | 12/3467 | 28/18723 | 2.53e-03 | 2.02e-02 | 12 |
GO:0006364 | Colorectum | MSS | rRNA processing | 58/3467 | 225/18723 | 4.17e-03 | 3.03e-02 | 58 |
GO:0016072 | Colorectum | MSS | rRNA metabolic process | 60/3467 | 236/18723 | 5.01e-03 | 3.46e-02 | 60 |
GO:00226183 | Colorectum | MSI-H | ribonucleoprotein complex assembly | 62/1319 | 220/18723 | 7.13e-22 | 8.32e-19 | 62 |
GO:00718263 | Colorectum | MSI-H | ribonucleoprotein complex subunit organization | 63/1319 | 227/18723 | 8.08e-22 | 8.32e-19 | 63 |
GO:00226133 | Colorectum | MSI-H | ribonucleoprotein complex biogenesis | 95/1319 | 463/18723 | 1.04e-21 | 8.32e-19 | 95 |
GO:00083803 | Colorectum | MSI-H | RNA splicing | 82/1319 | 434/18723 | 1.22e-16 | 4.53e-14 | 82 |
GO:00003753 | Colorectum | MSI-H | RNA splicing, via transesterification reactions | 67/1319 | 324/18723 | 7.99e-16 | 2.61e-13 | 67 |
GO:00003773 | Colorectum | MSI-H | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
GO:00003983 | Colorectum | MSI-H | mRNA splicing, via spliceosome | 66/1319 | 320/18723 | 1.51e-15 | 4.41e-13 | 66 |
GO:00422543 | Colorectum | MSI-H | ribosome biogenesis | 54/1319 | 299/18723 | 1.27e-10 | 2.07e-08 | 54 |
GO:00422733 | Colorectum | MSI-H | ribosomal large subunit biogenesis | 23/1319 | 72/18723 | 3.58e-10 | 5.23e-08 | 23 |
GO:00422742 | Colorectum | MSI-H | ribosomal small subunit biogenesis | 20/1319 | 73/18723 | 9.17e-08 | 9.10e-06 | 20 |
GO:00063641 | Colorectum | MSI-H | rRNA processing | 39/1319 | 225/18723 | 1.45e-07 | 1.32e-05 | 39 |
GO:00160721 | Colorectum | MSI-H | rRNA metabolic process | 39/1319 | 236/18723 | 5.20e-07 | 3.91e-05 | 39 |
GO:00004701 | Colorectum | MSI-H | maturation of LSU-rRNA | 10/1319 | 28/18723 | 1.18e-05 | 5.41e-04 | 10 |
GO:0034470 | Colorectum | MSI-H | ncRNA processing | 48/1319 | 395/18723 | 1.54e-04 | 4.47e-03 | 48 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030408 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304013 | Breast | Precancer | Spliceosome | 39/684 | 217/8465 | 1.44e-06 | 2.27e-05 | 1.74e-05 | 39 |
hsa0304023 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304033 | Breast | IDC | Spliceosome | 40/867 | 217/8465 | 1.53e-04 | 1.42e-03 | 1.06e-03 | 40 |
hsa0304043 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa0304053 | Breast | DCIS | Spliceosome | 40/846 | 217/8465 | 8.97e-05 | 8.52e-04 | 6.28e-04 | 40 |
hsa03040 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030401 | Colorectum | AD | Spliceosome | 73/2092 | 217/8465 | 1.73e-03 | 9.68e-03 | 6.18e-03 | 73 |
hsa030402 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030403 | Colorectum | MSS | Spliceosome | 66/1875 | 217/8465 | 2.58e-03 | 1.27e-02 | 7.81e-03 | 66 |
hsa030404 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030405 | Colorectum | MSI-H | Spliceosome | 37/797 | 217/8465 | 2.49e-04 | 3.23e-03 | 2.70e-03 | 37 |
hsa030409 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304014 | Endometrium | AEH | Spliceosome | 54/1197 | 217/8465 | 1.47e-05 | 1.65e-04 | 1.21e-04 | 54 |
hsa0304024 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304034 | Endometrium | EEC | Spliceosome | 54/1237 | 217/8465 | 3.78e-05 | 3.88e-04 | 2.89e-04 | 54 |
hsa0304027 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa0304037 | Esophagus | ESCC | Spliceosome | 128/4205 | 217/8465 | 3.31e-03 | 8.79e-03 | 4.50e-03 | 128 |
hsa030407 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
hsa0304012 | Liver | Cirrhotic | Spliceosome | 102/2530 | 217/8465 | 5.69e-08 | 9.47e-07 | 5.84e-07 | 102 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SNU13 | SNV | Missense_Mutation | c.329N>T | p.Ser110Leu | p.S110L | P55769 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
SNU13 | SNV | Missense_Mutation | novel | c.152N>G | p.Ser51Cys | p.S51C | P55769 | protein_coding | tolerated(0.18) | benign(0.186) | TCGA-C5-A1M7-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SNU13 | SNV | Missense_Mutation | c.329N>T | p.Ser110Leu | p.S110L | P55769 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
SNU13 | SNV | Missense_Mutation | c.52C>A | p.Leu18Ile | p.L18I | P55769 | protein_coding | deleterious(0.02) | benign(0.43) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
SNU13 | SNV | Missense_Mutation | c.301N>A | p.Ala101Thr | p.A101T | P55769 | protein_coding | deleterious(0.04) | benign(0.044) | TCGA-EI-6512-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folfox | SD | |
SNU13 | SNV | Missense_Mutation | novel | c.76N>A | p.Val26Ile | p.V26I | P55769 | protein_coding | tolerated(0.38) | benign(0.006) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
SNU13 | SNV | Missense_Mutation | novel | c.123G>T | p.Glu41Asp | p.E41D | P55769 | protein_coding | deleterious(0) | probably_damaging(0.928) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
SNU13 | SNV | Missense_Mutation | novel | c.149T>C | p.Ile50Thr | p.I50T | P55769 | protein_coding | tolerated(0.32) | benign(0.039) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNU13 | SNV | Missense_Mutation | novel | c.191N>T | p.Glu64Val | p.E64V | P55769 | protein_coding | deleterious(0) | probably_damaging(0.947) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SNU13 | SNV | Missense_Mutation | novel | c.370G>A | p.Glu124Lys | p.E124K | P55769 | protein_coding | deleterious(0) | benign(0.085) | TCGA-55-8089-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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