Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/SLC25A13_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/SLC25A13_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/SLC25A13_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/SLC25A13_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/SLC25A13_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/SLC25A13_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/SLC25A13_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/SLC25A13_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/SLC25A13_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Thyroid/SLC25A13_pca_on_diff_genes.png) | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00091522 | Colorectum | MSS | purine ribonucleotide biosynthetic process | 57/3467 | 169/18723 | 1.63e-06 | 5.32e-05 | 57 |
GO:00091412 | Colorectum | MSS | nucleoside triphosphate metabolic process | 42/3467 | 112/18723 | 1.75e-06 | 5.60e-05 | 42 |
GO:00092052 | Colorectum | MSS | purine ribonucleoside triphosphate metabolic process | 33/3467 | 82/18723 | 3.72e-06 | 1.07e-04 | 33 |
GO:00092602 | Colorectum | MSS | ribonucleotide biosynthetic process | 59/3467 | 182/18723 | 4.55e-06 | 1.27e-04 | 59 |
GO:00463902 | Colorectum | MSS | ribose phosphate biosynthetic process | 60/3467 | 190/18723 | 9.54e-06 | 2.33e-04 | 60 |
GO:00091992 | Colorectum | MSS | ribonucleoside triphosphate metabolic process | 34/3467 | 89/18723 | 1.03e-05 | 2.48e-04 | 34 |
GO:00091452 | Colorectum | MSS | purine nucleoside triphosphate biosynthetic process | 28/3467 | 69/18723 | 1.65e-05 | 3.64e-04 | 28 |
GO:00061642 | Colorectum | MSS | purine nucleotide biosynthetic process | 59/3467 | 191/18723 | 2.36e-05 | 4.97e-04 | 59 |
GO:00725222 | Colorectum | MSS | purine-containing compound biosynthetic process | 61/3467 | 200/18723 | 2.65e-05 | 5.46e-04 | 61 |
GO:00067542 | Colorectum | MSS | ATP biosynthetic process | 24/3467 | 57/18723 | 3.16e-05 | 6.29e-04 | 24 |
GO:00092062 | Colorectum | MSS | purine ribonucleoside triphosphate biosynthetic process | 27/3467 | 68/18723 | 3.68e-05 | 7.09e-04 | 27 |
GO:00091422 | Colorectum | MSS | nucleoside triphosphate biosynthetic process | 31/3467 | 85/18723 | 7.07e-05 | 1.21e-03 | 31 |
GO:00092012 | Colorectum | MSS | ribonucleoside triphosphate biosynthetic process | 28/3467 | 74/18723 | 7.38e-05 | 1.23e-03 | 28 |
GO:19012932 | Colorectum | MSS | nucleoside phosphate biosynthetic process | 71/3467 | 256/18723 | 1.80e-04 | 2.56e-03 | 71 |
GO:00091652 | Colorectum | MSS | nucleotide biosynthetic process | 70/3467 | 254/18723 | 2.44e-04 | 3.34e-03 | 70 |
GO:00193182 | Colorectum | MSS | hexose metabolic process | 63/3467 | 237/18723 | 1.32e-03 | 1.25e-02 | 63 |
GO:00059962 | Colorectum | MSS | monosaccharide metabolic process | 66/3467 | 257/18723 | 2.61e-03 | 2.06e-02 | 66 |
GO:00100382 | Colorectum | MSS | response to metal ion | 90/3467 | 373/18723 | 3.76e-03 | 2.76e-02 | 90 |
GO:00060062 | Colorectum | MSS | glucose metabolic process | 51/3467 | 196/18723 | 5.67e-03 | 3.85e-02 | 51 |
GO:00460344 | Colorectum | FAP | ATP metabolic process | 87/2622 | 277/18723 | 6.50e-14 | 6.63e-11 | 87 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
SLC25A13 | SNV | Missense_Mutation | rs376257669 | c.572N>A | p.Arg191His | p.R191H | Q9UJS0 | protein_coding | deleterious(0.02) | benign(0.049) | TCGA-A2-A0CT-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | SD |
SLC25A13 | SNV | Missense_Mutation | | c.874N>G | p.Arg292Gly | p.R292G | Q9UJS0 | protein_coding | tolerated(0.06) | benign(0.081) | TCGA-A7-A26G-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
SLC25A13 | SNV | Missense_Mutation | rs142308242 | c.874N>T | p.Arg292Trp | p.R292W | Q9UJS0 | protein_coding | deleterious(0) | possibly_damaging(0.586) | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD |
SLC25A13 | SNV | Missense_Mutation | | c.1460N>T | p.Ala487Val | p.A487V | Q9UJS0 | protein_coding | tolerated(0.06) | probably_damaging(0.933) | TCGA-E2-A1L9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
SLC25A13 | insertion | Frame_Shift_Ins | novel | c.943_944insTTATGTAC | p.Ser315PhefsTer42 | p.S315Ffs*42 | Q9UJS0 | protein_coding | | | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A13 | insertion | Nonsense_Mutation | novel | c.941_942insATATTTCTGAGACTCAGTATTATCAC | p.Ser315TyrfsTer3 | p.S315Yfs*3 | Q9UJS0 | protein_coding | | | TCGA-AN-A04C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A13 | SNV | Missense_Mutation | novel | c.690G>A | p.Met230Ile | p.M230I | Q9UJS0 | protein_coding | tolerated(0.09) | benign(0.222) | TCGA-C5-A7X5-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
SLC25A13 | SNV | Missense_Mutation | | c.871N>A | p.Glu291Lys | p.E291K | Q9UJS0 | protein_coding | tolerated(0.08) | benign(0.058) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
SLC25A13 | SNV | Missense_Mutation | | c.1001G>A | p.Gly334Asp | p.G334D | Q9UJS0 | protein_coding | tolerated(0.27) | benign(0.088) | TCGA-A6-3810-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
SLC25A13 | SNV | Missense_Mutation | | c.2010N>T | p.Lys670Asn | p.K670N | Q9UJS0 | protein_coding | tolerated_low_confidence(0.45) | benign(0.01) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |