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Gene: RPL35A |
Gene summary for RPL35A |
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Gene information | Species | Human | Gene symbol | RPL35A | Gene ID | 6165 |
Gene name | ribosomal protein L35a | |
Gene Alias | DBA5 | |
Cytomap | 3q29 | |
Gene Type | protein-coding | GO ID | GO:0002181 | UniProtAcc | P18077 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
6165 | RPL35A | GSM4909282 | Human | Breast | IDC | 2.90e-05 | -9.22e-02 | -0.0288 |
6165 | RPL35A | GSM4909285 | Human | Breast | IDC | 1.01e-61 | 3.01e-01 | 0.21 |
6165 | RPL35A | GSM4909286 | Human | Breast | IDC | 9.41e-45 | 2.26e-01 | 0.1081 |
6165 | RPL35A | GSM4909287 | Human | Breast | IDC | 4.10e-10 | -1.93e-01 | 0.2057 |
6165 | RPL35A | GSM4909294 | Human | Breast | IDC | 3.79e-07 | -1.58e-01 | 0.2022 |
6165 | RPL35A | GSM4909301 | Human | Breast | IDC | 1.94e-15 | -1.85e-01 | 0.1577 |
6165 | RPL35A | GSM4909302 | Human | Breast | IDC | 9.23e-11 | -2.17e-01 | 0.1545 |
6165 | RPL35A | GSM4909306 | Human | Breast | IDC | 2.65e-15 | -1.47e-01 | 0.1564 |
6165 | RPL35A | GSM4909307 | Human | Breast | IDC | 4.49e-20 | -1.77e-01 | 0.1569 |
6165 | RPL35A | GSM4909308 | Human | Breast | IDC | 1.78e-44 | -3.05e-01 | 0.158 |
6165 | RPL35A | GSM4909311 | Human | Breast | IDC | 1.05e-04 | 4.59e-02 | 0.1534 |
6165 | RPL35A | GSM4909313 | Human | Breast | IDC | 1.89e-03 | -1.46e-01 | 0.0391 |
6165 | RPL35A | GSM4909317 | Human | Breast | IDC | 1.63e-11 | -1.81e-01 | 0.1355 |
6165 | RPL35A | GSM4909319 | Human | Breast | IDC | 3.57e-39 | -6.21e-01 | 0.1563 |
6165 | RPL35A | GSM4909321 | Human | Breast | IDC | 4.64e-05 | -1.23e-01 | 0.1559 |
6165 | RPL35A | brca1 | Human | Breast | Precancer | 1.69e-10 | -1.02e-01 | -0.0338 |
6165 | RPL35A | brca2 | Human | Breast | Precancer | 1.88e-25 | -1.85e-01 | -0.024 |
6165 | RPL35A | brca3 | Human | Breast | Precancer | 2.69e-10 | -1.12e-01 | -0.0263 |
6165 | RPL35A | NCCBC14 | Human | Breast | DCIS | 2.96e-05 | -2.19e-01 | 0.2021 |
6165 | RPL35A | NCCBC3 | Human | Breast | DCIS | 1.94e-04 | -1.03e-01 | 0.1198 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0042254111 | Esophagus | ESCC | ribosome biogenesis | 252/8552 | 299/18723 | 3.27e-44 | 1.04e-40 | 252 |
GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
GO:0016072110 | Esophagus | ESCC | rRNA metabolic process | 197/8552 | 236/18723 | 1.31e-33 | 1.18e-30 | 197 |
GO:0006364110 | Esophagus | ESCC | rRNA processing | 189/8552 | 225/18723 | 4.88e-33 | 3.87e-30 | 189 |
GO:0002181111 | Esophagus | ESCC | cytoplasmic translation | 135/8552 | 148/18723 | 4.17e-32 | 2.65e-29 | 135 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:0042273111 | Esophagus | ESCC | ribosomal large subunit biogenesis | 65/8552 | 72/18723 | 1.53e-15 | 9.82e-14 | 65 |
GO:00021817 | Liver | NAFLD | cytoplasmic translation | 93/1882 | 148/18723 | 1.44e-55 | 8.41e-52 | 93 |
GO:00226137 | Liver | NAFLD | ribonucleoprotein complex biogenesis | 76/1882 | 463/18723 | 1.19e-05 | 3.67e-04 | 76 |
GO:00422737 | Liver | NAFLD | ribosomal large subunit biogenesis | 20/1882 | 72/18723 | 1.83e-05 | 5.29e-04 | 20 |
GO:00422547 | Liver | NAFLD | ribosome biogenesis | 52/1882 | 299/18723 | 6.03e-05 | 1.32e-03 | 52 |
GO:00344704 | Liver | NAFLD | ncRNA processing | 57/1882 | 395/18723 | 3.34e-03 | 2.93e-02 | 57 |
GO:00063644 | Liver | NAFLD | rRNA processing | 35/1882 | 225/18723 | 6.04e-03 | 4.54e-02 | 35 |
GO:000218112 | Liver | Cirrhotic | cytoplasmic translation | 120/4634 | 148/18723 | 2.95e-47 | 1.85e-43 | 120 |
GO:002261312 | Liver | Cirrhotic | ribonucleoprotein complex biogenesis | 231/4634 | 463/18723 | 3.28e-32 | 6.86e-29 | 231 |
GO:004225412 | Liver | Cirrhotic | ribosome biogenesis | 154/4634 | 299/18723 | 1.18e-23 | 6.72e-21 | 154 |
GO:000636412 | Liver | Cirrhotic | rRNA processing | 115/4634 | 225/18723 | 1.12e-17 | 1.64e-15 | 115 |
GO:00160724 | Liver | Cirrhotic | rRNA metabolic process | 119/4634 | 236/18723 | 1.19e-17 | 1.70e-15 | 119 |
GO:004227312 | Liver | Cirrhotic | ribosomal large subunit biogenesis | 47/4634 | 72/18723 | 4.20e-13 | 3.29e-11 | 47 |
GO:00344701 | Liver | Cirrhotic | ncRNA processing | 158/4634 | 395/18723 | 1.09e-11 | 6.96e-10 | 158 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0301018 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517118 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301019 | Breast | Precancer | Ribosome | 80/684 | 167/8465 | 7.33e-44 | 2.32e-41 | 1.77e-41 | 80 |
hsa0517119 | Breast | Precancer | Coronavirus disease - COVID-19 | 81/684 | 232/8465 | 3.74e-32 | 2.36e-30 | 1.81e-30 | 81 |
hsa0301024 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517124 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301034 | Breast | IDC | Ribosome | 83/867 | 167/8465 | 6.07e-39 | 9.87e-37 | 7.38e-37 | 83 |
hsa0517134 | Breast | IDC | Coronavirus disease - COVID-19 | 86/867 | 232/8465 | 1.50e-28 | 9.72e-27 | 7.27e-27 | 86 |
hsa0301044 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517144 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0301054 | Breast | DCIS | Ribosome | 82/846 | 167/8465 | 8.69e-39 | 1.40e-36 | 1.03e-36 | 82 |
hsa0517154 | Breast | DCIS | Coronavirus disease - COVID-19 | 86/846 | 232/8465 | 2.42e-29 | 1.56e-27 | 1.15e-27 | 86 |
hsa0517120 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa0301020 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa05171110 | Cervix | CC | Coronavirus disease - COVID-19 | 111/1267 | 232/8465 | 1.82e-33 | 5.90e-31 | 3.49e-31 | 111 |
hsa03010110 | Cervix | CC | Ribosome | 85/1267 | 167/8465 | 3.17e-28 | 5.14e-26 | 3.04e-26 | 85 |
hsa0301025 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517125 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
hsa0301035 | Cervix | HSIL_HPV | Ribosome | 80/459 | 167/8465 | 9.61e-58 | 2.82e-55 | 2.28e-55 | 80 |
hsa0517135 | Cervix | HSIL_HPV | Coronavirus disease - COVID-19 | 91/459 | 232/8465 | 2.14e-56 | 3.13e-54 | 2.53e-54 | 91 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RPL35A | SNV | Missense_Mutation | c.76N>A | p.Ala26Thr | p.A26T | P18077 | protein_coding | tolerated(0.07) | benign(0.108) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RPL35A | SNV | Missense_Mutation | novel | c.197N>C | p.Lys66Thr | p.K66T | P18077 | protein_coding | deleterious(0.01) | benign(0.123) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RPL35A | SNV | Missense_Mutation | c.137N>T | p.Arg46Ile | p.R46I | P18077 | protein_coding | deleterious(0) | probably_damaging(0.936) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
RPL35A | deletion | Frame_Shift_Del | novel | c.117_118delNN | p.Glu40IlefsTer12 | p.E40Ifs*12 | P18077 | protein_coding | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
RPL35A | SNV | Missense_Mutation | novel | c.41N>G | p.Tyr14Cys | p.Y14C | P18077 | protein_coding | deleterious(0.01) | benign(0.301) | TCGA-DD-AACY-01 | Liver | liver hepatocellular carcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
RPL35A | SNV | Missense_Mutation | novel | c.226N>G | p.Arg76Gly | p.R76G | P18077 | protein_coding | deleterious(0.01) | possibly_damaging(0.764) | TCGA-33-AAS8-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
RPL35A | SNV | Missense_Mutation | novel | c.134A>G | p.Lys45Arg | p.K45R | P18077 | protein_coding | deleterious(0.01) | possibly_damaging(0.887) | TCGA-85-8351-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | CR |
RPL35A | SNV | Missense_Mutation | rs116840808 | c.97N>A | p.Val33Ile | p.V33I | P18077 | protein_coding | deleterious(0.02) | possibly_damaging(0.692) | TCGA-XK-AAIW-01 | Prostate | prostate adenocarcinoma | Male | >=65 | 9 | Unknown | Unknown | PD |
RPL35A | SNV | Missense_Mutation | novel | c.91N>A | p.Glu31Lys | p.E31K | P18077 | protein_coding | deleterious(0.03) | benign(0.069) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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