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Gene: RHOC |
Gene summary for RHOC |
Gene summary. |
Gene information | Species | Human | Gene symbol | RHOC | Gene ID | 389 |
Gene name | ras homolog family member C | |
Gene Alias | ARH9 | |
Cytomap | 1p13.2 | |
Gene Type | protein-coding | GO ID | GO:0000278 | UniProtAcc | A0A024R0I3 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
389 | RHOC | GSM4909277 | Human | Breast | Precancer | 3.55e-03 | -5.07e-01 | 0.0177 |
389 | RHOC | GSM4909281 | Human | Breast | IDC | 1.09e-04 | -2.35e-01 | 0.21 |
389 | RHOC | GSM4909286 | Human | Breast | IDC | 4.61e-17 | -3.58e-01 | 0.1081 |
389 | RHOC | GSM4909288 | Human | Breast | IDC | 3.50e-04 | -4.54e-01 | 0.0988 |
389 | RHOC | GSM4909293 | Human | Breast | IDC | 2.33e-04 | -7.19e-02 | 0.1581 |
389 | RHOC | GSM4909294 | Human | Breast | IDC | 4.15e-11 | 3.04e-02 | 0.2022 |
389 | RHOC | GSM4909296 | Human | Breast | IDC | 3.65e-17 | 1.41e-01 | 0.1524 |
389 | RHOC | GSM4909297 | Human | Breast | IDC | 3.02e-28 | -3.68e-01 | 0.1517 |
389 | RHOC | GSM4909298 | Human | Breast | IDC | 1.17e-06 | -2.21e-01 | 0.1551 |
389 | RHOC | GSM4909301 | Human | Breast | IDC | 8.92e-15 | -4.63e-01 | 0.1577 |
389 | RHOC | GSM4909304 | Human | Breast | IDC | 1.50e-03 | 3.07e-01 | 0.1636 |
389 | RHOC | GSM4909311 | Human | Breast | IDC | 1.39e-48 | -1.38e-01 | 0.1534 |
389 | RHOC | GSM4909312 | Human | Breast | IDC | 1.21e-22 | 2.32e-01 | 0.1552 |
389 | RHOC | GSM4909313 | Human | Breast | IDC | 1.57e-05 | -6.19e-02 | 0.0391 |
389 | RHOC | GSM4909315 | Human | Breast | IDC | 1.04e-24 | 5.26e-01 | 0.21 |
389 | RHOC | GSM4909316 | Human | Breast | IDC | 2.80e-17 | 4.69e-01 | 0.21 |
389 | RHOC | GSM4909318 | Human | Breast | IDC | 9.73e-03 | -4.62e-01 | 0.2031 |
389 | RHOC | GSM4909319 | Human | Breast | IDC | 8.55e-69 | -3.27e-01 | 0.1563 |
389 | RHOC | GSM4909320 | Human | Breast | IDC | 8.84e-10 | -3.74e-01 | 0.1575 |
389 | RHOC | GSM4909321 | Human | Breast | IDC | 2.36e-19 | -1.94e-01 | 0.1559 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00905053 | Cervix | CC | epiboly involved in wound healing | 17/2311 | 34/18723 | 9.86e-08 | 5.25e-06 | 17 |
GO:00905043 | Cervix | CC | epiboly | 17/2311 | 35/18723 | 1.70e-07 | 7.93e-06 | 17 |
GO:006157210 | Cervix | CC | actin filament bundle organization | 44/2311 | 161/18723 | 2.08e-07 | 9.34e-06 | 44 |
GO:005101710 | Cervix | CC | actin filament bundle assembly | 43/2311 | 157/18723 | 2.66e-07 | 1.12e-05 | 43 |
GO:00343298 | Cervix | CC | cell junction assembly | 88/2311 | 420/18723 | 3.42e-07 | 1.38e-05 | 88 |
GO:00070439 | Cervix | CC | cell-cell junction assembly | 39/2311 | 146/18723 | 1.86e-06 | 5.94e-05 | 39 |
GO:00020111 | Cervix | CC | morphogenesis of an epithelial sheet | 21/2311 | 57/18723 | 1.91e-06 | 5.97e-05 | 21 |
GO:003133410 | Cervix | CC | positive regulation of protein-containing complex assembly | 55/2311 | 237/18723 | 2.25e-06 | 6.73e-05 | 55 |
GO:190290510 | Cervix | CC | positive regulation of supramolecular fiber organization | 50/2311 | 209/18723 | 2.55e-06 | 7.54e-05 | 50 |
GO:00432978 | Cervix | CC | apical junction assembly | 24/2311 | 78/18723 | 1.36e-05 | 2.73e-04 | 24 |
GO:00083608 | Cervix | CC | regulation of cell shape | 38/2311 | 154/18723 | 1.86e-05 | 3.46e-04 | 38 |
GO:005149510 | Cervix | CC | positive regulation of cytoskeleton organization | 50/2311 | 226/18723 | 2.53e-05 | 4.29e-04 | 50 |
GO:00431228 | Cervix | CC | regulation of I-kappaB kinase/NF-kappaB signaling | 53/2311 | 249/18723 | 4.50e-05 | 6.87e-04 | 53 |
GO:003223110 | Cervix | CC | regulation of actin filament bundle assembly | 28/2311 | 105/18723 | 5.19e-05 | 7.79e-04 | 28 |
GO:011002010 | Cervix | CC | regulation of actomyosin structure organization | 27/2311 | 100/18723 | 5.55e-05 | 8.10e-04 | 27 |
GO:005149210 | Cervix | CC | regulation of stress fiber assembly | 25/2311 | 91/18723 | 7.59e-05 | 1.04e-03 | 25 |
GO:00308657 | Cervix | CC | cortical cytoskeleton organization | 19/2311 | 61/18723 | 8.72e-05 | 1.16e-03 | 19 |
GO:00310329 | Cervix | CC | actomyosin structure organization | 43/2311 | 196/18723 | 1.11e-04 | 1.40e-03 | 43 |
GO:003003810 | Cervix | CC | contractile actin filament bundle assembly | 27/2311 | 106/18723 | 1.63e-04 | 1.94e-03 | 27 |
GO:004314910 | Cervix | CC | stress fiber assembly | 27/2311 | 106/18723 | 1.63e-04 | 1.94e-03 | 27 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RHOC | SNV | Missense_Mutation | novel | c.125N>G | p.Tyr42Cys | p.Y42C | P08134 | protein_coding | deleterious(0.02) | possibly_damaging(0.654) | TCGA-AC-A3OD-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHOC | SNV | Missense_Mutation | novel | c.424N>A | p.Glu142Lys | p.E142K | P08134 | protein_coding | deleterious(0.04) | benign(0.105) | TCGA-AR-A2LK-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | anastrozole | PD |
RHOC | insertion | Nonsense_Mutation | novel | c.12_13insTGGCCCTCTGAGGGCATACTACTGTTGAGGTTTTGA | p.Ile4_Arg5insTrpProSerGluGlyIleLeuLeuLeuArgPheTer | p.I4_R5insWPSEGILLLRF* | P08134 | protein_coding | TCGA-AO-A03T-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
RHOC | SNV | Missense_Mutation | c.70G>A | p.Val24Ile | p.V24I | P08134 | protein_coding | deleterious(0.03) | benign(0.058) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RHOC | SNV | Missense_Mutation | novel | c.82N>T | p.Asp28Tyr | p.D28Y | P08134 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-VS-A957-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
RHOC | SNV | Missense_Mutation | c.358N>A | p.Asp120Asn | p.D120N | P08134 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RHOC | SNV | Missense_Mutation | novel | c.82G>T | p.Asp28Tyr | p.D28Y | P08134 | protein_coding | deleterious(0.01) | probably_damaging(0.954) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
RHOC | SNV | Missense_Mutation | rs766734264 | c.526N>T | p.Arg176Trp | p.R176W | P08134 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
RHOC | SNV | Missense_Mutation | c.193N>T | p.Asp65Tyr | p.D65Y | P08134 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-QG-A5YV-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | |
RHOC | SNV | Missense_Mutation | rs779520374 | c.502C>T | p.Arg168Trp | p.R168W | P08134 | protein_coding | deleterious(0.03) | probably_damaging(0.982) | TCGA-EF-5830-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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