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Gene: RAB27A |
Gene summary for RAB27A |
Gene summary. |
Gene information | Species | Human | Gene symbol | RAB27A | Gene ID | 5873 |
Gene name | RAB27A, member RAS oncogene family | |
Gene Alias | GS2 | |
Cytomap | 15q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | A2RU94 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5873 | RAB27A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.40e-03 | -2.99e-01 | 0.0155 |
5873 | RAB27A | HTA11_2112_2000001011 | Human | Colorectum | SER | 2.86e-04 | 9.66e-01 | -0.2196 |
5873 | RAB27A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 9.37e-10 | -3.31e-01 | 0.3859 |
5873 | RAB27A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 8.25e-10 | -3.29e-01 | 0.3005 |
5873 | RAB27A | A002-C-010 | Human | Colorectum | FAP | 8.73e-06 | -1.57e-01 | 0.242 |
5873 | RAB27A | A015-C-203 | Human | Colorectum | FAP | 3.02e-15 | -3.22e-01 | -0.1294 |
5873 | RAB27A | A015-C-204 | Human | Colorectum | FAP | 1.87e-02 | -2.27e-01 | -0.0228 |
5873 | RAB27A | A002-C-201 | Human | Colorectum | FAP | 9.56e-08 | -2.53e-01 | 0.0324 |
5873 | RAB27A | A002-C-203 | Human | Colorectum | FAP | 8.53e-04 | -2.11e-01 | 0.2786 |
5873 | RAB27A | A001-C-119 | Human | Colorectum | FAP | 2.64e-03 | -2.44e-01 | -0.1557 |
5873 | RAB27A | A001-C-108 | Human | Colorectum | FAP | 2.27e-12 | -2.92e-01 | -0.0272 |
5873 | RAB27A | A002-C-205 | Human | Colorectum | FAP | 3.41e-11 | -3.16e-01 | -0.1236 |
5873 | RAB27A | A001-C-104 | Human | Colorectum | FAP | 6.45e-07 | -2.39e-01 | 0.0184 |
5873 | RAB27A | A015-C-005 | Human | Colorectum | FAP | 1.01e-02 | -1.88e-01 | -0.0336 |
5873 | RAB27A | A015-C-006 | Human | Colorectum | FAP | 5.00e-05 | -2.50e-01 | -0.0994 |
5873 | RAB27A | A015-C-106 | Human | Colorectum | FAP | 2.46e-07 | -2.27e-01 | -0.0511 |
5873 | RAB27A | A002-C-114 | Human | Colorectum | FAP | 6.25e-10 | -3.31e-01 | -0.1561 |
5873 | RAB27A | A015-C-104 | Human | Colorectum | FAP | 9.53e-15 | -3.04e-01 | -0.1899 |
5873 | RAB27A | A001-C-014 | Human | Colorectum | FAP | 1.17e-08 | -2.23e-01 | 0.0135 |
5873 | RAB27A | A002-C-016 | Human | Colorectum | FAP | 9.47e-10 | -2.39e-01 | 0.0521 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00160504 | Colorectum | CRC | vesicle organization | 57/2078 | 300/18723 | 3.36e-05 | 8.57e-04 | 57 |
GO:19901824 | Colorectum | CRC | exosomal secretion | 9/2078 | 20/18723 | 1.34e-04 | 2.55e-03 | 9 |
GO:00977344 | Colorectum | CRC | extracellular exosome biogenesis | 9/2078 | 21/18723 | 2.12e-04 | 3.56e-03 | 9 |
GO:00508785 | Colorectum | CRC | regulation of body fluid levels | 65/2078 | 379/18723 | 2.38e-04 | 3.96e-03 | 65 |
GO:01401124 | Colorectum | CRC | extracellular vesicle biogenesis | 9/2078 | 23/18723 | 4.80e-04 | 6.90e-03 | 9 |
GO:00066055 | Colorectum | CRC | protein targeting | 54/2078 | 314/18723 | 7.17e-04 | 9.28e-03 | 54 |
GO:00459214 | Colorectum | CRC | positive regulation of exocytosis | 19/2078 | 86/18723 | 2.44e-03 | 2.31e-02 | 19 |
GO:19035323 | Colorectum | CRC | positive regulation of secretion by cell | 47/2078 | 282/18723 | 2.91e-03 | 2.64e-02 | 47 |
GO:00070324 | Colorectum | CRC | endosome organization | 18/2078 | 82/18723 | 3.37e-03 | 2.88e-02 | 18 |
GO:00510474 | Colorectum | CRC | positive regulation of secretion | 50/2078 | 310/18723 | 4.31e-03 | 3.47e-02 | 50 |
GO:00171573 | Colorectum | CRC | regulation of exocytosis | 35/2078 | 202/18723 | 5.03e-03 | 3.86e-02 | 35 |
GO:00362573 | Colorectum | CRC | multivesicular body organization | 9/2078 | 31/18723 | 5.21e-03 | 3.97e-02 | 9 |
GO:00068872 | Colorectum | CRC | exocytosis | 55/2078 | 352/18723 | 5.62e-03 | 4.24e-02 | 55 |
GO:0006605111 | Esophagus | ESCC | protein targeting | 229/8552 | 314/18723 | 4.93e-23 | 1.01e-20 | 229 |
GO:005165617 | Esophagus | ESCC | establishment of organelle localization | 273/8552 | 390/18723 | 9.13e-23 | 1.81e-20 | 273 |
GO:001605014 | Esophagus | ESCC | vesicle organization | 211/8552 | 300/18723 | 2.85e-18 | 2.87e-16 | 211 |
GO:005165016 | Esophagus | ESCC | establishment of vesicle localization | 114/8552 | 161/18723 | 8.20e-11 | 2.53e-09 | 114 |
GO:003625714 | Esophagus | ESCC | multivesicular body organization | 30/8552 | 31/18723 | 1.04e-09 | 2.50e-08 | 30 |
GO:007198514 | Esophagus | ESCC | multivesicular body sorting pathway | 34/8552 | 37/18723 | 3.49e-09 | 7.39e-08 | 34 |
GO:005164815 | Esophagus | ESCC | vesicle localization | 119/8552 | 177/18723 | 5.16e-09 | 1.08e-07 | 119 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
RAB27A | SNV | Missense_Mutation | c.610N>T | p.His204Tyr | p.H204Y | P51159 | protein_coding | tolerated(0.05) | benign(0.009) | TCGA-E9-A1N8-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
RAB27A | SNV | Missense_Mutation | c.599N>A | p.Arg200Gln | p.R200Q | P51159 | protein_coding | tolerated(0.64) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
RAB27A | SNV | Missense_Mutation | c.188G>A | p.Gly63Asp | p.G63D | P51159 | protein_coding | deleterious(0.01) | benign(0.1) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
RAB27A | SNV | Missense_Mutation | c.520A>C | p.Ile174Leu | p.I174L | P51159 | protein_coding | deleterious(0.04) | benign(0.04) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
RAB27A | SNV | Missense_Mutation | c.112N>C | p.Phe38Leu | p.F38L | P51159 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
RAB27A | deletion | Frame_Shift_Del | c.297delN | p.Phe99LeufsTer3 | p.F99Lfs*3 | P51159 | protein_coding | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
RAB27A | SNV | Missense_Mutation | c.502N>G | p.Thr168Ala | p.T168A | P51159 | protein_coding | tolerated(0.7) | benign(0) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RAB27A | SNV | Missense_Mutation | c.642N>T | p.Lys214Asn | p.K214N | P51159 | protein_coding | tolerated(0.3) | benign(0.013) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
RAB27A | SNV | Missense_Mutation | novel | c.13G>T | p.Asp5Tyr | p.D5Y | P51159 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
RAB27A | SNV | Missense_Mutation | novel | c.271N>T | p.Asp91Tyr | p.D91Y | P51159 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5873 | RAB27A | ENZYME | inhibitor | 328083519 | ||
5873 | RAB27A | ENZYME | emapalumab | EMAPALUMAB | ||
5873 | RAB27A | ENZYME | Emapalumab-lzsg | EMAPALUMAB |
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