Tissue | Expression Dynamics | Abbreviation |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003139816 | Esophagus | ESCC | positive regulation of protein ubiquitination | 82/8552 | 119/18723 | 2.41e-07 | 3.64e-06 | 82 |
GO:00510908 | Esophagus | ESCC | regulation of DNA-binding transcription factor activity | 252/8552 | 440/18723 | 5.22e-07 | 6.97e-06 | 252 |
GO:19040294 | Esophagus | ESCC | regulation of cyclin-dependent protein kinase activity | 69/8552 | 98/18723 | 6.04e-07 | 7.91e-06 | 69 |
GO:00000794 | Esophagus | ESCC | regulation of cyclin-dependent protein serine/threonine kinase activity | 66/8552 | 94/18723 | 1.24e-06 | 1.53e-05 | 66 |
GO:0030330110 | Esophagus | ESCC | DNA damage response, signal transduction by p53 class mediator | 53/8552 | 72/18723 | 1.34e-06 | 1.63e-05 | 53 |
GO:009019914 | Esophagus | ESCC | regulation of release of cytochrome c from mitochondria | 38/8552 | 48/18723 | 2.11e-06 | 2.43e-05 | 38 |
GO:00719029 | Esophagus | ESCC | positive regulation of protein serine/threonine kinase activity | 124/8552 | 200/18723 | 2.27e-06 | 2.61e-05 | 124 |
GO:004586018 | Esophagus | ESCC | positive regulation of protein kinase activity | 219/8552 | 386/18723 | 6.91e-06 | 6.97e-05 | 219 |
GO:003367420 | Esophagus | ESCC | positive regulation of kinase activity | 260/8552 | 467/18723 | 7.26e-06 | 7.22e-05 | 260 |
GO:001082315 | Esophagus | ESCC | negative regulation of mitochondrion organization | 36/8552 | 49/18723 | 7.24e-05 | 5.45e-04 | 36 |
GO:19040312 | Esophagus | ESCC | positive regulation of cyclin-dependent protein kinase activity | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:003030710 | Esophagus | ESCC | positive regulation of cell growth | 100/8552 | 166/18723 | 1.07e-04 | 7.55e-04 | 100 |
GO:200102112 | Esophagus | ESCC | negative regulation of response to DNA damage stimulus | 54/8552 | 81/18723 | 1.09e-04 | 7.64e-04 | 54 |
GO:00457372 | Esophagus | ESCC | positive regulation of cyclin-dependent protein serine/threonine kinase activity | 23/8552 | 29/18723 | 2.25e-04 | 1.40e-03 | 23 |
GO:0043409110 | Esophagus | ESCC | negative regulation of MAPK cascade | 105/8552 | 180/18723 | 4.13e-04 | 2.35e-03 | 105 |
GO:005122013 | Esophagus | ESCC | cytoplasmic sequestering of protein | 18/8552 | 22/18723 | 5.69e-04 | 3.10e-03 | 18 |
GO:004324811 | Esophagus | ESCC | proteasome assembly | 11/8552 | 12/18723 | 1.26e-03 | 6.06e-03 | 11 |
GO:009020112 | Esophagus | ESCC | negative regulation of release of cytochrome c from mitochondria | 16/8552 | 20/18723 | 1.85e-03 | 8.40e-03 | 16 |
GO:00434332 | Esophagus | ESCC | negative regulation of DNA-binding transcription factor activity | 103/8552 | 185/18723 | 3.86e-03 | 1.57e-02 | 103 |
GO:19017975 | Esophagus | ESCC | negative regulation of signal transduction by p53 class mediator | 22/8552 | 31/18723 | 3.90e-03 | 1.58e-02 | 22 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PSMD10 | SNV | Missense_Mutation | novel | c.140N>T | p.Ala47Val | p.A47V | O75832 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-AO-A1KS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
PSMD10 | SNV | Missense_Mutation | | c.475C>A | p.Leu159Met | p.L159M | O75832 | protein_coding | deleterious(0.02) | possibly_damaging(0.887) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PSMD10 | SNV | Missense_Mutation | novel | c.352N>G | p.Arg118Gly | p.R118G | O75832 | protein_coding | tolerated(0.08) | benign(0.084) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
PSMD10 | SNV | Missense_Mutation | novel | c.175N>G | p.Leu59Val | p.L59V | O75832 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PSMD10 | SNV | Missense_Mutation | novel | c.671N>G | p.Val224Gly | p.V224G | O75832 | protein_coding | deleterious(0.01) | benign(0.026) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PSMD10 | SNV | Missense_Mutation | novel | c.424N>A | p.Ala142Thr | p.A142T | O75832 | protein_coding | deleterious(0) | benign(0.14) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
PSMD10 | SNV | Missense_Mutation | novel | c.239N>T | p.Ala80Val | p.A80V | O75832 | protein_coding | deleterious(0) | probably_damaging(0.984) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PSMD10 | SNV | Missense_Mutation | novel | c.466N>A | p.His156Asn | p.H156N | O75832 | protein_coding | tolerated(0.22) | benign(0.023) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
PSMD10 | SNV | Missense_Mutation | novel | c.657A>G | p.Ile219Met | p.I219M | O75832 | protein_coding | tolerated(0.29) | benign(0.01) | TCGA-B5-A3FA-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PSMD10 | SNV | Missense_Mutation | | c.462G>T | p.Met154Ile | p.M154I | O75832 | protein_coding | tolerated(1) | benign(0.001) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |