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Gene: POP4 |
Gene summary for POP4 |
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Gene information | Species | Human | Gene symbol | POP4 | Gene ID | 10775 |
Gene name | POP4 homolog, ribonuclease P/MRP subunit | |
Gene Alias | RPP29 | |
Cytomap | 19q12 | |
Gene Type | protein-coding | GO ID | GO:0000966 | UniProtAcc | O95707 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10775 | POP4 | LZE4T | Human | Esophagus | ESCC | 5.38e-07 | 2.12e-01 | 0.0811 |
10775 | POP4 | LZE7T | Human | Esophagus | ESCC | 2.15e-05 | 4.67e-01 | 0.0667 |
10775 | POP4 | LZE8T | Human | Esophagus | ESCC | 9.50e-10 | 2.10e-01 | 0.067 |
10775 | POP4 | LZE20T | Human | Esophagus | ESCC | 4.95e-07 | 2.25e-01 | 0.0662 |
10775 | POP4 | LZE24T | Human | Esophagus | ESCC | 2.35e-21 | 3.93e-01 | 0.0596 |
10775 | POP4 | LZE21T | Human | Esophagus | ESCC | 4.53e-04 | 2.69e-01 | 0.0655 |
10775 | POP4 | LZE6T | Human | Esophagus | ESCC | 2.05e-05 | 3.41e-01 | 0.0845 |
10775 | POP4 | P1T-E | Human | Esophagus | ESCC | 3.48e-12 | 5.87e-01 | 0.0875 |
10775 | POP4 | P2T-E | Human | Esophagus | ESCC | 2.16e-26 | 3.56e-01 | 0.1177 |
10775 | POP4 | P4T-E | Human | Esophagus | ESCC | 1.74e-22 | 5.47e-01 | 0.1323 |
10775 | POP4 | P5T-E | Human | Esophagus | ESCC | 2.60e-25 | 5.25e-01 | 0.1327 |
10775 | POP4 | P8T-E | Human | Esophagus | ESCC | 4.89e-39 | 7.12e-01 | 0.0889 |
10775 | POP4 | P9T-E | Human | Esophagus | ESCC | 8.47e-13 | 4.61e-01 | 0.1131 |
10775 | POP4 | P10T-E | Human | Esophagus | ESCC | 9.40e-24 | 5.68e-01 | 0.116 |
10775 | POP4 | P11T-E | Human | Esophagus | ESCC | 4.52e-11 | 6.61e-01 | 0.1426 |
10775 | POP4 | P12T-E | Human | Esophagus | ESCC | 1.37e-26 | 4.58e-01 | 0.1122 |
10775 | POP4 | P15T-E | Human | Esophagus | ESCC | 2.14e-20 | 4.52e-01 | 0.1149 |
10775 | POP4 | P16T-E | Human | Esophagus | ESCC | 9.79e-17 | 2.82e-01 | 0.1153 |
10775 | POP4 | P17T-E | Human | Esophagus | ESCC | 2.76e-10 | 4.51e-01 | 0.1278 |
10775 | POP4 | P19T-E | Human | Esophagus | ESCC | 4.81e-11 | 8.23e-01 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063993 | Skin | cSCC | tRNA metabolic process | 64/4864 | 179/18723 | 2.34e-03 | 1.36e-02 | 64 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0042254113 | Thyroid | PTC | ribosome biogenesis | 202/5968 | 299/18723 | 3.47e-37 | 5.47e-34 | 202 |
GO:0006364112 | Thyroid | PTC | rRNA processing | 156/5968 | 225/18723 | 5.58e-31 | 5.03e-28 | 156 |
GO:0016072112 | Thyroid | PTC | rRNA metabolic process | 160/5968 | 236/18723 | 5.68e-30 | 3.58e-27 | 160 |
GO:003447018 | Thyroid | PTC | ncRNA processing | 215/5968 | 395/18723 | 7.14e-21 | 1.22e-18 | 215 |
GO:00346608 | Thyroid | PTC | ncRNA metabolic process | 239/5968 | 485/18723 | 5.54e-16 | 4.26e-14 | 239 |
GO:00905015 | Thyroid | PTC | RNA phosphodiester bond hydrolysis | 76/5968 | 152/18723 | 2.40e-06 | 3.17e-05 | 76 |
GO:00903055 | Thyroid | PTC | nucleic acid phosphodiester bond hydrolysis | 105/5968 | 261/18723 | 2.53e-03 | 1.31e-02 | 105 |
GO:002261334 | Thyroid | ATC | ribonucleoprotein complex biogenesis | 292/6293 | 463/18723 | 3.05e-39 | 9.63e-36 | 292 |
GO:004225434 | Thyroid | ATC | ribosome biogenesis | 203/6293 | 299/18723 | 3.63e-34 | 4.59e-31 | 203 |
GO:000636432 | Thyroid | ATC | rRNA processing | 157/6293 | 225/18723 | 9.02e-29 | 5.70e-26 | 157 |
GO:001607232 | Thyroid | ATC | rRNA metabolic process | 161/6293 | 236/18723 | 1.02e-27 | 5.89e-25 | 161 |
GO:003447021 | Thyroid | ATC | ncRNA processing | 216/6293 | 395/18723 | 3.14e-18 | 3.98e-16 | 216 |
GO:003466021 | Thyroid | ATC | ncRNA metabolic process | 240/6293 | 485/18723 | 2.03e-13 | 9.91e-12 | 240 |
GO:009050112 | Thyroid | ATC | RNA phosphodiester bond hydrolysis | 76/6293 | 152/18723 | 2.07e-05 | 1.86e-04 | 76 |
GO:009030511 | Thyroid | ATC | nucleic acid phosphodiester bond hydrolysis | 107/6293 | 261/18723 | 7.21e-03 | 2.84e-02 | 107 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
POP4 | SNV | Missense_Mutation | novel | c.655G>A | p.Asp219Asn | p.D219N | O95707 | protein_coding | deleterious(0) | benign(0.406) | TCGA-JW-AAVH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
POP4 | SNV | Missense_Mutation | rs547007300 | c.517C>T | p.Arg173Cys | p.R173C | O95707 | protein_coding | deleterious(0.04) | benign(0.027) | TCGA-4T-AA8H-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POP4 | SNV | Missense_Mutation | rs565503123 | c.116N>T | p.Thr39Met | p.T39M | O95707 | protein_coding | tolerated(0.27) | benign(0) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POP4 | SNV | Missense_Mutation | novel | c.406C>T | p.His136Tyr | p.H136Y | O95707 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
POP4 | SNV | Missense_Mutation | rs140893351 | c.41C>T | p.Ala14Val | p.A14V | O95707 | protein_coding | deleterious(0.03) | benign(0.186) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
POP4 | SNV | Missense_Mutation | c.607C>T | p.Arg203Trp | p.R203W | O95707 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
POP4 | SNV | Missense_Mutation | rs758843443 | c.131N>T | p.Pro44Leu | p.P44L | O95707 | protein_coding | tolerated(0.2) | benign(0.011) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
POP4 | SNV | Missense_Mutation | novel | c.500N>G | p.Ile167Ser | p.I167S | O95707 | protein_coding | deleterious(0) | probably_damaging(0.932) | TCGA-AP-A1E0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
POP4 | SNV | Missense_Mutation | c.50N>T | p.Ser17Phe | p.S17F | O95707 | protein_coding | tolerated(0.5) | benign(0) | TCGA-AX-A2H5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR | |
POP4 | SNV | Missense_Mutation | rs758843443 | c.131N>T | p.Pro44Leu | p.P44L | O95707 | protein_coding | tolerated(0.2) | benign(0.011) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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