Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/PLS1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/PLS1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/PLS1_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
GC | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/GC/PLS1_pca_on_diff_genes.png) | CAG: Chronic atrophic gastritis |
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia |
CSG: Chronic superficial gastritis |
GC: Gastric cancer |
SIM: Severe intestinal metaplasia |
WIM: Wild intestinal metaplasia |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/PLS1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00424911 | Colorectum | MSS | inner ear auditory receptor cell differentiation | 16/3467 | 38/18723 | 6.47e-04 | 7.06e-03 | 16 |
GO:00486381 | Colorectum | MSS | regulation of developmental growth | 84/3467 | 330/18723 | 1.01e-03 | 1.01e-02 | 84 |
GO:00486391 | Colorectum | MSS | positive regulation of developmental growth | 49/3467 | 174/18723 | 1.17e-03 | 1.13e-02 | 49 |
GO:00459272 | Colorectum | MSS | positive regulation of growth | 68/3467 | 259/18723 | 1.24e-03 | 1.19e-02 | 68 |
GO:00600882 | Colorectum | MSS | auditory receptor cell stereocilium organization | 8/3467 | 14/18723 | 1.42e-03 | 1.32e-02 | 8 |
GO:00601191 | Colorectum | MSS | inner ear receptor cell development | 17/3467 | 45/18723 | 1.89e-03 | 1.65e-02 | 17 |
GO:00226001 | Colorectum | MSS | digestive system process | 31/3467 | 104/18723 | 3.46e-03 | 2.59e-02 | 31 |
GO:00424901 | Colorectum | MSS | mechanoreceptor differentiation | 22/3467 | 67/18723 | 3.57e-03 | 2.64e-02 | 22 |
GO:00020931 | Colorectum | MSS | auditory receptor cell morphogenesis | 8/3467 | 16/18723 | 4.27e-03 | 3.04e-02 | 8 |
GO:0035264 | Colorectum | MSS | multicellular organism growth | 37/3467 | 132/18723 | 4.77e-03 | 3.34e-02 | 37 |
GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
GO:00099131 | Colorectum | MSS | epidermal cell differentiation | 52/3467 | 202/18723 | 6.59e-03 | 4.38e-02 | 52 |
GO:0060113 | Colorectum | MSS | inner ear receptor cell differentiation | 20/3467 | 62/18723 | 6.63e-03 | 4.38e-02 | 20 |
GO:00726594 | Colorectum | FAP | protein localization to plasma membrane | 95/2622 | 284/18723 | 4.86e-17 | 9.93e-14 | 95 |
GO:00070154 | Colorectum | FAP | actin filament organization | 125/2622 | 442/18723 | 1.97e-15 | 3.03e-12 | 125 |
GO:19907784 | Colorectum | FAP | protein localization to cell periphery | 100/2622 | 333/18723 | 2.19e-14 | 2.68e-11 | 100 |
GO:19054753 | Colorectum | FAP | regulation of protein localization to membrane | 58/2622 | 175/18723 | 9.05e-11 | 2.92e-08 | 58 |
GO:19038294 | Colorectum | FAP | positive regulation of cellular protein localization | 79/2622 | 276/18723 | 1.59e-10 | 4.38e-08 | 79 |
GO:00325353 | Colorectum | FAP | regulation of cellular component size | 99/2622 | 383/18723 | 4.53e-10 | 1.16e-07 | 99 |
GO:19043753 | Colorectum | FAP | regulation of protein localization to cell periphery | 43/2622 | 125/18723 | 6.69e-09 | 1.00e-06 | 43 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PLS1 | SNV | Missense_Mutation | | c.1849N>C | p.Phe617Leu | p.F617L | Q14651 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PLS1 | SNV | Missense_Mutation | | c.1712N>A | p.Arg571Lys | p.R571K | Q14651 | protein_coding | tolerated(1) | benign(0) | TCGA-E9-A1RH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | SD |
PLS1 | SNV | Missense_Mutation | rs773749532 | c.1526C>T | p.Ser509Leu | p.S509L | Q14651 | protein_coding | deleterious(0.02) | probably_damaging(0.988) | TCGA-EW-A1OV-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | epirubicin | SD |
PLS1 | SNV | Missense_Mutation | novel | c.605N>G | p.Ser202Cys | p.S202C | Q14651 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-PE-A5DE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
PLS1 | insertion | Frame_Shift_Ins | novel | c.1245_1246insAAAAA | p.His416LysfsTer12 | p.H416Kfs*12 | Q14651 | protein_coding | | | TCGA-A8-A08C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PLS1 | insertion | In_Frame_Ins | novel | c.1246_1247insAAA | p.His416delinsGlnAsn | p.H416delinsQN | Q14651 | protein_coding | | | TCGA-A8-A08C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
PLS1 | insertion | Nonsense_Mutation | novel | c.1534_1535insGAGAGGGGTAATGTTCATTTTATGATACAGATCTCTGGGCAGGGGTAAGAGA | p.Glu515Ter | p.E515* | Q14651 | protein_coding | | | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
PLS1 | SNV | Missense_Mutation | | c.233N>T | p.Ser78Leu | p.S78L | Q14651 | protein_coding | tolerated(0.07) | benign(0.272) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD |
PLS1 | SNV | Missense_Mutation | | c.1515N>C | p.Leu505Phe | p.L505F | Q14651 | protein_coding | deleterious(0.03) | possibly_damaging(0.521) | TCGA-EK-A3GJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PLS1 | SNV | Missense_Mutation | | c.529N>C | p.Ile177Leu | p.I177L | Q14651 | protein_coding | deleterious(0) | benign(0.179) | TCGA-IR-A3LC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unspecific | Cisplatin | Complete Response |