Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: PIAS1

Gene summary for PIAS1

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

PIAS1

Gene ID

8554

Gene nameprotein inhibitor of activated STAT 1
Gene AliasDDXBP1
Cytomap15q23
Gene Typeprotein-coding
GO ID

GO:0000003

UniProtAcc

O75925


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
8554PIAS1CCI_2HumanCervixCC1.38e-111.35e+000.5249
8554PIAS1CCI_3HumanCervixCC2.25e-057.26e-010.516
8554PIAS1L1HumanCervixCC1.18e-02-1.57e-010.0802
8554PIAS1HTA11_3410_2000001011HumanColorectumAD2.64e-14-4.77e-010.0155
8554PIAS1HTA11_3361_2000001011HumanColorectumAD1.99e-02-4.74e-01-0.1207
8554PIAS1HTA11_866_2000001011HumanColorectumAD9.34e-04-3.32e-01-0.1001
8554PIAS1HTA11_866_3004761011HumanColorectumAD4.48e-08-4.58e-010.096
8554PIAS1HTA11_7663_2000001011HumanColorectumSER7.74e-03-2.90e-010.0131
8554PIAS1HTA11_10711_2000001011HumanColorectumAD3.18e-05-4.74e-010.0338
8554PIAS1HTA11_7696_3000711011HumanColorectumAD1.66e-10-4.67e-010.0674
8554PIAS1HTA11_99999970781_79442HumanColorectumMSS1.08e-07-3.99e-010.294
8554PIAS1HTA11_99999971662_82457HumanColorectumMSS1.21e-09-5.12e-010.3859
8554PIAS1HTA11_99999973899_84307HumanColorectumMSS4.64e-02-4.93e-010.2585
8554PIAS1HTA11_99999974143_84620HumanColorectumMSS2.23e-06-4.61e-010.3005
8554PIAS1A001-C-207HumanColorectumFAP1.69e-03-2.40e-010.1278
8554PIAS1A015-C-203HumanColorectumFAP1.79e-27-3.88e-01-0.1294
8554PIAS1A015-C-204HumanColorectumFAP2.01e-07-3.47e-01-0.0228
8554PIAS1A014-C-040HumanColorectumFAP2.19e-04-3.51e-01-0.1184
8554PIAS1A002-C-201HumanColorectumFAP8.24e-17-3.59e-010.0324
8554PIAS1A002-C-203HumanColorectumFAP4.10e-04-1.96e-010.2786
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:20000602ColorectumMSSpositive regulation of ubiquitin-dependent protein catabolic process39/3467107/187238.92e-062.19e-0439
GO:19018002ColorectumMSSpositive regulation of proteasomal protein catabolic process40/3467114/187231.96e-054.19e-0440
GO:00324362ColorectumMSSpositive regulation of proteasomal ubiquitin-dependent protein catabolic process32/346790/187239.56e-051.50e-0332
GO:00098964ColorectumFAPpositive regulation of catabolic process126/2622492/187233.76e-122.56e-09126
GO:00421764ColorectumFAPregulation of protein catabolic process106/2622391/187235.00e-123.06e-09106
GO:00313314ColorectumFAPpositive regulation of cellular catabolic process110/2622427/187236.09e-112.19e-08110
GO:00431614ColorectumFAPproteasome-mediated ubiquitin-dependent protein catabolic process98/2622412/187235.41e-084.20e-0698
GO:19033624ColorectumFAPregulation of cellular protein catabolic process68/2622255/187236.50e-084.54e-0668
GO:00104984ColorectumFAPproteasomal protein catabolic process110/2622490/187232.12e-071.26e-05110
GO:20000584ColorectumFAPregulation of ubiquitin-dependent protein catabolic process48/2622164/187232.88e-071.63e-0548
GO:00457324ColorectumFAPpositive regulation of protein catabolic process61/2622231/187234.38e-072.35e-0561
GO:19033204ColorectumFAPregulation of protein modification by small protein conjugation or removal61/2622242/187232.36e-069.21e-0561
GO:19030504ColorectumFAPregulation of proteolysis involved in cellular protein catabolic process54/2622221/187232.26e-055.32e-0454
GO:00458624ColorectumFAPpositive regulation of proteolysis81/2622372/187232.64e-056.08e-0481
GO:19033644ColorectumFAPpositive regulation of cellular protein catabolic process40/2622155/187236.94e-051.31e-0340
GO:00324344ColorectumFAPregulation of proteasomal ubiquitin-dependent protein catabolic process35/2622134/187231.48e-042.29e-0335
GO:20000604ColorectumFAPpositive regulation of ubiquitin-dependent protein catabolic process29/2622107/187232.69e-043.64e-0329
GO:19030524ColorectumFAPpositive regulation of proteolysis involved in cellular protein catabolic process32/2622133/187231.28e-031.19e-0232
GO:00611364ColorectumFAPregulation of proteasomal protein catabolic process40/2622187/187233.69e-032.62e-0240
GO:00324364ColorectumFAPpositive regulation of proteasomal ubiquitin-dependent protein catabolic process22/262290/187235.61e-033.61e-0222
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa0412014CervixCCUbiquitin mediated proteolysis49/1267142/84654.26e-097.68e-084.54e-0849
hsa0412015CervixCCUbiquitin mediated proteolysis49/1267142/84654.26e-097.68e-084.54e-0849
hsa04120ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa05160ColorectumADHepatitis C54/2092157/84653.87e-031.96e-021.25e-0254
hsa041201ColorectumADUbiquitin mediated proteolysis58/2092142/84651.46e-051.53e-049.76e-0558
hsa051601ColorectumADHepatitis C54/2092157/84653.87e-031.96e-021.25e-0254
hsa041202ColorectumSERUbiquitin mediated proteolysis39/1580142/84656.18e-033.66e-022.66e-0239
hsa041203ColorectumSERUbiquitin mediated proteolysis39/1580142/84656.18e-033.66e-022.66e-0239
hsa041204ColorectumMSSUbiquitin mediated proteolysis55/1875142/84655.02e-066.00e-053.68e-0555
hsa051602ColorectumMSSHepatitis C52/1875157/84659.29e-045.58e-033.42e-0352
hsa041205ColorectumMSSUbiquitin mediated proteolysis55/1875142/84655.02e-066.00e-053.68e-0555
hsa051603ColorectumMSSHepatitis C52/1875157/84659.29e-045.58e-033.42e-0352
hsa041206ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041207ColorectumFAPUbiquitin mediated proteolysis51/1404142/84651.55e-085.84e-073.55e-0751
hsa041208ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa041209ColorectumCRCUbiquitin mediated proteolysis42/1091142/84659.98e-086.67e-064.52e-0642
hsa0412026EsophagusHGINUbiquitin mediated proteolysis49/1383142/84657.78e-081.33e-061.06e-0649
hsa04120111EsophagusHGINUbiquitin mediated proteolysis49/1383142/84657.78e-081.33e-061.06e-0649
hsa0412027EsophagusESCCUbiquitin mediated proteolysis122/4205142/84656.53e-207.29e-183.74e-18122
hsa051609EsophagusESCCHepatitis C107/4205157/84651.75e-061.08e-055.55e-06107
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
PIAS1SNVMissense_Mutationnovelc.946N>Cp.Glu316Glnp.E316QO75925protein_codingdeleterious(0.01)probably_damaging(0.917)TCGA-B6-A40B-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PIAS1SNVMissense_Mutationc.1063C>Tp.His355Tyrp.H355YO75925protein_codingdeleterious(0)probably_damaging(1)TCGA-C8-A26Y-01Breastbreast invasive carcinomaFemale>=65I/IIUnknownUnknownSD
PIAS1SNVMissense_Mutationnovelc.97C>Ap.His33Asnp.H33NO75925protein_codingtolerated(0.07)benign(0.031)TCGA-OL-A6VR-01Breastbreast invasive carcinomaFemale<65I/IIUnknownUnknownSD
PIAS1insertionFrame_Shift_Insnovelc.1948_1949insATGCTCCCACACATCCTCAp.Ile650AsnfsTer43p.I650Nfs*43O75925protein_codingTCGA-A2-A0EO-01Breastbreast invasive carcinomaFemale<65I/IIHormone TherapytamoxiphenSD
PIAS1insertionFrame_Shift_Insnovelc.1729_1730insATTTTTTTATCTTTTATACCATATTp.Leu577HisfsTer25p.L577Hfs*25O75925protein_codingTCGA-AO-A0JD-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapycyclophosphamideSD
PIAS1SNVMissense_Mutationnovelc.985N>Cp.Thr329Prop.T329PO75925protein_codingdeleterious(0)probably_damaging(0.995)TCGA-2W-A8YY-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
PIAS1SNVMissense_Mutationnovelc.569N>Gp.Ser190Cysp.S190CO75925protein_codingdeleterious(0.01)probably_damaging(0.962)TCGA-C5-A7X5-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycarboplatinPD
PIAS1SNVMissense_Mutationc.1250C>Tp.Pro417Leup.P417LO75925protein_codingdeleterious(0)possibly_damaging(0.701)TCGA-A6-2686-01Colorectumcolon adenocarcinomaFemale>=65I/IIUnknownUnknownSD
PIAS1SNVMissense_Mutationc.1372N>Gp.Lys458Glup.K458EO75925protein_codingdeleterious(0)benign(0.18)TCGA-A6-4105-01Colorectumcolon adenocarcinomaMale>=65I/IIUnknownUnknownPD
PIAS1SNVMissense_Mutationc.85N>Ap.Gly29Argp.G29RO75925protein_codingdeleterious(0)probably_damaging(0.999)TCGA-AA-3947-01Colorectumcolon adenocarcinomaFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
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