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Gene: PDE8A |
Gene summary for PDE8A |
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Gene information | Species | Human | Gene symbol | PDE8A | Gene ID | 5151 |
Gene name | phosphodiesterase 8A | |
Gene Alias | HsT19550 | |
Cytomap | 15q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O60658 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
5151 | PDE8A | CCI_1 | Human | Cervix | CC | 2.75e-11 | 1.17e+00 | 0.528 |
5151 | PDE8A | CCI_3 | Human | Cervix | CC | 3.33e-08 | 4.78e-01 | 0.516 |
5151 | PDE8A | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.53e-50 | -1.02e+00 | 0.0155 |
5151 | PDE8A | HTA11_2951_2000001011 | Human | Colorectum | AD | 4.24e-14 | -9.97e-01 | 0.0216 |
5151 | PDE8A | HTA11_347_2000001011 | Human | Colorectum | AD | 3.14e-15 | 7.83e-01 | -0.1954 |
5151 | PDE8A | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.08e-05 | -5.55e-01 | -0.1207 |
5151 | PDE8A | HTA11_696_2000001011 | Human | Colorectum | AD | 1.86e-05 | -2.95e-01 | -0.1464 |
5151 | PDE8A | HTA11_5212_2000001011 | Human | Colorectum | AD | 2.88e-03 | -4.38e-01 | -0.2061 |
5151 | PDE8A | HTA11_866_3004761011 | Human | Colorectum | AD | 1.55e-39 | -9.13e-01 | 0.096 |
5151 | PDE8A | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.33e-09 | -9.96e-01 | 0.0451 |
5151 | PDE8A | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.58e-15 | -9.36e-01 | 0.0528 |
5151 | PDE8A | HTA11_10711_2000001011 | Human | Colorectum | AD | 8.87e-20 | -8.25e-01 | 0.0338 |
5151 | PDE8A | HTA11_7696_3000711011 | Human | Colorectum | AD | 5.92e-33 | -7.40e-01 | 0.0674 |
5151 | PDE8A | HTA11_11156_2000001011 | Human | Colorectum | AD | 6.01e-03 | -8.62e-01 | 0.0397 |
5151 | PDE8A | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.02e-22 | -8.24e-01 | 0.0588 |
5151 | PDE8A | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.76e-52 | -9.66e-01 | 0.294 |
5151 | PDE8A | HTA11_99999971662_82457 | Human | Colorectum | MSS | 8.48e-42 | -8.39e-01 | 0.3859 |
5151 | PDE8A | HTA11_99999973899_84307 | Human | Colorectum | MSS | 9.93e-10 | -7.73e-01 | 0.2585 |
5151 | PDE8A | HTA11_99999974143_84620 | Human | Colorectum | MSS | 5.79e-43 | -9.15e-01 | 0.3005 |
5151 | PDE8A | F007 | Human | Colorectum | FAP | 2.35e-15 | -7.62e-01 | 0.1176 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00442702 | Colorectum | MSS | cellular nitrogen compound catabolic process | 141/3467 | 451/18723 | 2.95e-11 | 3.83e-09 | 141 |
GO:00725212 | Colorectum | MSS | purine-containing compound metabolic process | 132/3467 | 416/18723 | 4.13e-11 | 4.86e-09 | 132 |
GO:00467002 | Colorectum | MSS | heterocycle catabolic process | 139/3467 | 445/18723 | 4.37e-11 | 5.05e-09 | 139 |
GO:00346552 | Colorectum | MSS | nucleobase-containing compound catabolic process | 129/3467 | 407/18723 | 7.48e-11 | 8.18e-09 | 129 |
GO:00092592 | Colorectum | MSS | ribonucleotide metabolic process | 123/3467 | 385/18723 | 1.17e-10 | 1.20e-08 | 123 |
GO:19013612 | Colorectum | MSS | organic cyclic compound catabolic process | 148/3467 | 495/18723 | 3.47e-10 | 3.18e-08 | 148 |
GO:00196932 | Colorectum | MSS | ribose phosphate metabolic process | 124/3467 | 396/18723 | 4.11e-10 | 3.49e-08 | 124 |
GO:00194392 | Colorectum | MSS | aromatic compound catabolic process | 140/3467 | 467/18723 | 8.56e-10 | 6.85e-08 | 140 |
GO:00091172 | Colorectum | MSS | nucleotide metabolic process | 144/3467 | 489/18723 | 1.87e-09 | 1.35e-07 | 144 |
GO:00067532 | Colorectum | MSS | nucleoside phosphate metabolic process | 145/3467 | 497/18723 | 3.25e-09 | 2.23e-07 | 145 |
GO:00069792 | Colorectum | MSS | response to oxidative stress | 128/3467 | 446/18723 | 7.65e-08 | 3.81e-06 | 128 |
GO:00621972 | Colorectum | MSS | cellular response to chemical stress | 102/3467 | 337/18723 | 9.73e-08 | 4.71e-06 | 102 |
GO:00345992 | Colorectum | MSS | cellular response to oxidative stress | 88/3467 | 288/18723 | 4.58e-07 | 1.77e-05 | 88 |
GO:00003022 | Colorectum | MSS | response to reactive oxygen species | 67/3467 | 222/18723 | 1.60e-05 | 3.60e-04 | 67 |
GO:00364732 | Colorectum | MSS | cell death in response to oxidative stress | 33/3467 | 95/18723 | 1.26e-04 | 1.93e-03 | 33 |
GO:00708492 | Colorectum | MSS | response to epidermal growth factor | 20/3467 | 49/18723 | 2.36e-04 | 3.24e-03 | 20 |
GO:00346142 | Colorectum | MSS | cellular response to reactive oxygen species | 47/3467 | 155/18723 | 2.45e-04 | 3.34e-03 | 47 |
GO:00425422 | Colorectum | MSS | response to hydrogen peroxide | 44/3467 | 146/18723 | 4.40e-04 | 5.30e-03 | 44 |
GO:19004072 | Colorectum | MSS | regulation of cellular response to oxidative stress | 30/3467 | 89/18723 | 4.51e-04 | 5.38e-03 | 30 |
GO:19032012 | Colorectum | MSS | regulation of oxidative stress-induced cell death | 26/3467 | 74/18723 | 5.15e-04 | 5.97e-03 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDE8A | SNV | Missense_Mutation | c.1484A>T | p.Glu495Val | p.E495V | O60658 | protein_coding | tolerated(0.06) | benign(0.094) | TCGA-BH-A0GZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
PDE8A | SNV | Missense_Mutation | c.476N>G | p.Val159Gly | p.V159G | O60658 | protein_coding | deleterious(0) | possibly_damaging(0.893) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
PDE8A | SNV | Missense_Mutation | rs192339320 | c.704N>A | p.Arg235His | p.R235H | O60658 | protein_coding | tolerated(1) | benign(0) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDE8A | SNV | Missense_Mutation | novel | c.2039N>G | p.Phe680Cys | p.F680C | O60658 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
PDE8A | SNV | Missense_Mutation | c.2174C>T | p.Ala725Val | p.A725V | O60658 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
PDE8A | SNV | Missense_Mutation | novel | c.1501N>T | p.Asp501Tyr | p.D501Y | O60658 | protein_coding | deleterious(0) | possibly_damaging(0.478) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
PDE8A | SNV | Missense_Mutation | c.1130N>T | p.Arg377Leu | p.R377L | O60658 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-CM-5863-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatin | SD | |
PDE8A | SNV | Missense_Mutation | novel | c.1672N>C | p.Ser558Pro | p.S558P | O60658 | protein_coding | deleterious(0) | probably_damaging(0.955) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PDE8A | deletion | Frame_Shift_Del | c.800delN | p.Lys269ArgfsTer8 | p.K269Rfs*8 | O60658 | protein_coding | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
PDE8A | deletion | Frame_Shift_Del | c.800delN | p.Lys269ArgfsTer8 | p.K269Rfs*8 | O60658 | protein_coding | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
5151 | PDE8A | DRUGGABLE GENOME, ENZYME | inhibitor | 178101509 | DIPYRIDAMOLE | |
5151 | PDE8A | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL932 | DIPYRIDAMOLE | |
5151 | PDE8A | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL628 | PENTOXIFYLLINE | |
5151 | PDE8A | DRUGGABLE GENOME, ENZYME | inhibitor | CHEMBL1200875 | FLAVOXATE HYDROCHLORIDE | |
5151 | PDE8A | DRUGGABLE GENOME, ENZYME | inhibitor | 348353618 |
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