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Gene: PDCL3 |
Gene summary for PDCL3 |
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Gene information | Species | Human | Gene symbol | PDCL3 | Gene ID | 79031 |
Gene name | phosducin like 3 | |
Gene Alias | HTPHLP | |
Cytomap | 2q11.2 | |
Gene Type | protein-coding | GO ID | GO:0001525 | UniProtAcc | Q9H2J4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79031 | PDCL3 | LZE2T | Human | Esophagus | ESCC | 4.49e-03 | 7.05e-01 | 0.082 |
79031 | PDCL3 | LZE4T | Human | Esophagus | ESCC | 4.51e-23 | 6.32e-01 | 0.0811 |
79031 | PDCL3 | LZE7T | Human | Esophagus | ESCC | 5.00e-12 | 7.34e-01 | 0.0667 |
79031 | PDCL3 | LZE8T | Human | Esophagus | ESCC | 5.87e-12 | 2.15e-01 | 0.067 |
79031 | PDCL3 | LZE20T | Human | Esophagus | ESCC | 1.25e-08 | 2.69e-01 | 0.0662 |
79031 | PDCL3 | LZE21D1 | Human | Esophagus | HGIN | 2.41e-02 | 1.85e-01 | 0.0632 |
79031 | PDCL3 | LZE22T | Human | Esophagus | ESCC | 1.51e-04 | 4.50e-01 | 0.068 |
79031 | PDCL3 | LZE24D1 | Human | Esophagus | HGIN | 3.32e-02 | 3.74e-01 | 0.054 |
79031 | PDCL3 | LZE24T | Human | Esophagus | ESCC | 5.28e-15 | 4.60e-01 | 0.0596 |
79031 | PDCL3 | LZE21T | Human | Esophagus | ESCC | 2.96e-03 | 3.78e-01 | 0.0655 |
79031 | PDCL3 | LZE6T | Human | Esophagus | ESCC | 8.05e-18 | 7.03e-01 | 0.0845 |
79031 | PDCL3 | P1T-E | Human | Esophagus | ESCC | 4.26e-08 | 5.58e-01 | 0.0875 |
79031 | PDCL3 | P2T-E | Human | Esophagus | ESCC | 1.19e-41 | 7.91e-01 | 0.1177 |
79031 | PDCL3 | P4T-E | Human | Esophagus | ESCC | 1.89e-49 | 1.07e+00 | 0.1323 |
79031 | PDCL3 | P5T-E | Human | Esophagus | ESCC | 1.31e-37 | 7.71e-01 | 0.1327 |
79031 | PDCL3 | P8T-E | Human | Esophagus | ESCC | 1.67e-25 | 5.29e-01 | 0.0889 |
79031 | PDCL3 | P9T-E | Human | Esophagus | ESCC | 4.17e-36 | 8.11e-01 | 0.1131 |
79031 | PDCL3 | P10T-E | Human | Esophagus | ESCC | 1.45e-48 | 8.38e-01 | 0.116 |
79031 | PDCL3 | P11T-E | Human | Esophagus | ESCC | 7.87e-20 | 1.17e+00 | 0.1426 |
79031 | PDCL3 | P12T-E | Human | Esophagus | ESCC | 3.58e-51 | 8.79e-01 | 0.1122 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004217620 | Oral cavity | OSCC | regulation of protein catabolic process | 254/7305 | 391/18723 | 1.07e-25 | 3.22e-23 | 254 |
GO:000645718 | Oral cavity | OSCC | protein folding | 154/7305 | 212/18723 | 1.89e-23 | 4.60e-21 | 154 |
GO:190336220 | Oral cavity | OSCC | regulation of cellular protein catabolic process | 174/7305 | 255/18723 | 2.04e-21 | 3.70e-19 | 174 |
GO:003164720 | Oral cavity | OSCC | regulation of protein stability | 193/7305 | 298/18723 | 1.30e-19 | 1.95e-17 | 193 |
GO:190305020 | Oral cavity | OSCC | regulation of proteolysis involved in cellular protein catabolic process | 152/7305 | 221/18723 | 2.16e-19 | 3.15e-17 | 152 |
GO:200005820 | Oral cavity | OSCC | regulation of ubiquitin-dependent protein catabolic process | 118/7305 | 164/18723 | 9.37e-18 | 9.27e-16 | 118 |
GO:005082120 | Oral cavity | OSCC | protein stabilization | 122/7305 | 191/18723 | 2.69e-12 | 1.09e-10 | 122 |
GO:006107718 | Oral cavity | OSCC | chaperone-mediated protein folding | 54/7305 | 67/18723 | 3.73e-12 | 1.45e-10 | 54 |
GO:000989519 | Oral cavity | OSCC | negative regulation of catabolic process | 180/7305 | 320/18723 | 2.44e-10 | 6.86e-09 | 180 |
GO:003133020 | Oral cavity | OSCC | negative regulation of cellular catabolic process | 152/7305 | 262/18723 | 3.04e-10 | 8.28e-09 | 152 |
GO:003460519 | Oral cavity | OSCC | cellular response to heat | 51/7305 | 69/18723 | 4.00e-09 | 8.95e-08 | 51 |
GO:000940817 | Oral cavity | OSCC | response to heat | 73/7305 | 110/18723 | 5.56e-09 | 1.21e-07 | 73 |
GO:004217719 | Oral cavity | OSCC | negative regulation of protein catabolic process | 77/7305 | 121/18723 | 3.49e-08 | 6.64e-07 | 77 |
GO:004586120 | Oral cavity | OSCC | negative regulation of proteolysis | 181/7305 | 351/18723 | 1.01e-06 | 1.37e-05 | 181 |
GO:200005919 | Oral cavity | OSCC | negative regulation of ubiquitin-dependent protein catabolic process | 35/7305 | 48/18723 | 1.93e-06 | 2.47e-05 | 35 |
GO:190336317 | Oral cavity | OSCC | negative regulation of cellular protein catabolic process | 49/7305 | 75/18723 | 3.49e-06 | 4.15e-05 | 49 |
GO:000926616 | Oral cavity | OSCC | response to temperature stimulus | 98/7305 | 178/18723 | 9.78e-06 | 1.03e-04 | 98 |
GO:005067310 | Oral cavity | OSCC | epithelial cell proliferation | 212/7305 | 437/18723 | 2.82e-05 | 2.61e-04 | 212 |
GO:190305117 | Oral cavity | OSCC | negative regulation of proteolysis involved in cellular protein catabolic process | 41/7305 | 64/18723 | 4.31e-05 | 3.71e-04 | 41 |
GO:00182123 | Oral cavity | OSCC | peptidyl-tyrosine modification | 180/7305 | 378/18723 | 3.63e-04 | 2.22e-03 | 180 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PDCL3 | SNV | Missense_Mutation | novel | c.574N>C | p.Asp192His | p.D192H | Q9H2J4 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-A2-A0CR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR |
PDCL3 | SNV | Missense_Mutation | c.517N>C | p.Asp173His | p.D173H | Q9H2J4 | protein_coding | deleterious(0.03) | possibly_damaging(0.894) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
PDCL3 | SNV | Missense_Mutation | c.478N>C | p.Asp160His | p.D160H | Q9H2J4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A1EV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
PDCL3 | SNV | Missense_Mutation | novel | c.181N>C | p.Asp61His | p.D61H | Q9H2J4 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C8-A8HQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
PDCL3 | SNV | Missense_Mutation | novel | c.241N>A | p.Glu81Lys | p.E81K | Q9H2J4 | protein_coding | deleterious(0) | benign(0.034) | TCGA-MY-A5BE-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
PDCL3 | SNV | Missense_Mutation | novel | c.572N>A | p.Arg191Lys | p.R191K | Q9H2J4 | protein_coding | tolerated(0.89) | benign(0.001) | TCGA-VS-A8EL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
PDCL3 | SNV | Missense_Mutation | rs750858703 | c.44N>A | p.Arg15His | p.R15H | Q9H2J4 | protein_coding | deleterious(0.02) | benign(0.024) | TCGA-A6-6654-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
PDCL3 | SNV | Missense_Mutation | rs771734941 | c.673N>T | p.Arg225Trp | p.R225W | Q9H2J4 | protein_coding | tolerated(0.06) | benign(0.035) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PDCL3 | SNV | Missense_Mutation | rs763398924 | c.227N>A | p.Arg76Gln | p.R76Q | Q9H2J4 | protein_coding | tolerated(1) | benign(0.003) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
PDCL3 | SNV | Missense_Mutation | c.588N>T | p.Trp196Cys | p.W196C | Q9H2J4 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AA-A022-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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