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Gene: PAIP2 |
Gene summary for PAIP2 |
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Gene information | Species | Human | Gene symbol | PAIP2 | Gene ID | 51247 |
Gene name | poly(A) binding protein interacting protein 2 | |
Gene Alias | PAIP-2 | |
Cytomap | 5q31.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | Q49AE6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51247 | PAIP2 | LZE4T | Human | Esophagus | ESCC | 5.98e-14 | 6.05e-01 | 0.0811 |
51247 | PAIP2 | LZE7T | Human | Esophagus | ESCC | 3.84e-07 | 4.74e-01 | 0.0667 |
51247 | PAIP2 | LZE8T | Human | Esophagus | ESCC | 1.48e-09 | 6.41e-01 | 0.067 |
51247 | PAIP2 | LZE20T | Human | Esophagus | ESCC | 9.37e-05 | 1.67e-01 | 0.0662 |
51247 | PAIP2 | LZE22T | Human | Esophagus | ESCC | 1.18e-02 | 4.60e-01 | 0.068 |
51247 | PAIP2 | LZE24T | Human | Esophagus | ESCC | 6.72e-24 | 1.05e+00 | 0.0596 |
51247 | PAIP2 | LZE22D3 | Human | Esophagus | HGIN | 5.97e-03 | 1.34e-01 | 0.0653 |
51247 | PAIP2 | LZE21T | Human | Esophagus | ESCC | 1.41e-02 | 6.17e-01 | 0.0655 |
51247 | PAIP2 | LZE6T | Human | Esophagus | ESCC | 1.26e-07 | 7.77e-01 | 0.0845 |
51247 | PAIP2 | P2T-E | Human | Esophagus | ESCC | 6.53e-68 | 1.41e+00 | 0.1177 |
51247 | PAIP2 | P4T-E | Human | Esophagus | ESCC | 1.79e-35 | 1.09e+00 | 0.1323 |
51247 | PAIP2 | P5T-E | Human | Esophagus | ESCC | 1.03e-35 | 8.34e-01 | 0.1327 |
51247 | PAIP2 | P8T-E | Human | Esophagus | ESCC | 1.50e-28 | 5.71e-01 | 0.0889 |
51247 | PAIP2 | P9T-E | Human | Esophagus | ESCC | 1.26e-32 | 9.56e-01 | 0.1131 |
51247 | PAIP2 | P10T-E | Human | Esophagus | ESCC | 4.23e-53 | 1.11e+00 | 0.116 |
51247 | PAIP2 | P11T-E | Human | Esophagus | ESCC | 2.46e-24 | 1.31e+00 | 0.1426 |
51247 | PAIP2 | P12T-E | Human | Esophagus | ESCC | 2.72e-69 | 1.74e+00 | 0.1122 |
51247 | PAIP2 | P15T-E | Human | Esophagus | ESCC | 2.44e-39 | 1.18e+00 | 0.1149 |
51247 | PAIP2 | P16T-E | Human | Esophagus | ESCC | 4.95e-50 | 1.18e+00 | 0.1153 |
51247 | PAIP2 | P17T-E | Human | Esophagus | ESCC | 3.89e-06 | 8.56e-01 | 0.1278 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000644632 | Thyroid | ATC | regulation of translational initiation | 55/6293 | 79/18723 | 6.38e-11 | 2.06e-09 | 55 |
GO:003424923 | Thyroid | ATC | negative regulation of cellular amide metabolic process | 121/6293 | 273/18723 | 1.36e-04 | 9.57e-04 | 121 |
GO:004594722 | Thyroid | ATC | negative regulation of translational initiation | 14/6293 | 19/18723 | 4.17e-04 | 2.50e-03 | 14 |
GO:001714823 | Thyroid | ATC | negative regulation of translation | 107/6293 | 245/18723 | 6.17e-04 | 3.51e-03 | 107 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
PAIP2 | insertion | Frame_Shift_Ins | novel | c.88_89insAAAAAGAAAA | p.Pro30GlnfsTer14 | p.P30Qfs*14 | Q9BPZ3 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
PAIP2 | SNV | Missense_Mutation | novel | c.64N>A | p.Gly22Ser | p.G22S | Q9BPZ3 | protein_coding | tolerated(0.14) | benign(0.013) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
PAIP2 | SNV | Missense_Mutation | novel | c.296N>A | p.Gly99Asp | p.G99D | Q9BPZ3 | protein_coding | tolerated(0.32) | benign(0.284) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
PAIP2 | SNV | Missense_Mutation | rs779602855 | c.175N>T | p.Arg59Cys | p.R59C | Q9BPZ3 | protein_coding | deleterious(0.03) | possibly_damaging(0.521) | TCGA-SL-A6J9-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
PAIP2 | SNV | Missense_Mutation | c.253G>T | p.Asp85Tyr | p.D85Y | Q9BPZ3 | protein_coding | deleterious(0.01) | benign(0.354) | TCGA-75-5126-01 | Lung | lung adenocarcinoma | Female | Unknown | III/IV | Unknown | Unknown | SD | |
PAIP2 | SNV | Missense_Mutation | novel | c.329A>T | p.Asn110Ile | p.N110I | Q9BPZ3 | protein_coding | tolerated(0.14) | benign(0.029) | TCGA-78-7155-01 | Lung | lung adenocarcinoma | Male | >=65 | I/II | Chemotherapy | carboplatin | PD |
PAIP2 | SNV | Missense_Mutation | novel | c.257N>T | p.Gln86Leu | p.Q86L | Q9BPZ3 | protein_coding | deleterious(0.01) | benign(0.097) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
PAIP2 | SNV | Missense_Mutation | novel | c.176G>A | p.Arg59His | p.R59H | Q9BPZ3 | protein_coding | deleterious(0.01) | possibly_damaging(0.521) | TCGA-HU-A4H8-01 | Stomach | stomach adenocarcinoma | Male | >=65 | I/II | Chemotherapy | didox | PD |
PAIP2 | SNV | Missense_Mutation | c.233N>A | p.Arg78Gln | p.R78Q | Q9BPZ3 | protein_coding | deleterious(0.05) | benign(0.006) | TCGA-VQ-A8P2-01 | Stomach | stomach adenocarcinoma | Male | >=65 | III/IV | Unspecific | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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