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Gene: OCLN |
Gene summary for OCLN |
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Gene information | Species | Human | Gene symbol | OCLN | Gene ID | 100506658 |
Gene name | occludin | |
Gene Alias | BLCPMG | |
Cytomap | 5q13.2 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | A8K3T2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100506658 | OCLN | HTA11_3410_2000001011 | Human | Colorectum | AD | 1.39e-14 | -5.77e-01 | 0.0155 |
100506658 | OCLN | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.22e-02 | -4.08e-01 | -0.1808 |
100506658 | OCLN | HTA11_1938_2000001011 | Human | Colorectum | AD | 9.40e-03 | -4.28e-01 | -0.0811 |
100506658 | OCLN | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.78e-05 | -5.58e-01 | -0.1207 |
100506658 | OCLN | HTA11_696_2000001011 | Human | Colorectum | AD | 2.59e-07 | -3.96e-01 | -0.1464 |
100506658 | OCLN | HTA11_866_2000001011 | Human | Colorectum | AD | 6.82e-08 | -3.85e-01 | -0.1001 |
100506658 | OCLN | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.68e-02 | -4.12e-01 | -0.059 |
100506658 | OCLN | HTA11_546_2000001011 | Human | Colorectum | AD | 2.22e-03 | -5.48e-01 | -0.0842 |
100506658 | OCLN | HTA11_866_3004761011 | Human | Colorectum | AD | 5.77e-10 | -5.27e-01 | 0.096 |
100506658 | OCLN | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.62e-04 | -4.67e-01 | 0.0338 |
100506658 | OCLN | HTA11_7696_3000711011 | Human | Colorectum | AD | 8.49e-19 | -5.49e-01 | 0.0674 |
100506658 | OCLN | HTA11_6818_2000001021 | Human | Colorectum | AD | 6.49e-06 | -5.96e-01 | 0.0588 |
100506658 | OCLN | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.17e-15 | -5.14e-01 | 0.294 |
100506658 | OCLN | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.60e-11 | -4.83e-01 | 0.3005 |
100506658 | OCLN | F007 | Human | Colorectum | FAP | 7.01e-03 | -2.93e-01 | 0.1176 |
100506658 | OCLN | A002-C-010 | Human | Colorectum | FAP | 1.92e-06 | -2.84e-01 | 0.242 |
100506658 | OCLN | A001-C-207 | Human | Colorectum | FAP | 2.02e-05 | -3.09e-01 | 0.1278 |
100506658 | OCLN | A015-C-203 | Human | Colorectum | FAP | 2.15e-33 | -5.06e-01 | -0.1294 |
100506658 | OCLN | A015-C-204 | Human | Colorectum | FAP | 1.60e-09 | -4.49e-01 | -0.0228 |
100506658 | OCLN | A014-C-040 | Human | Colorectum | FAP | 8.52e-07 | -5.51e-01 | -0.1184 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19027452 | Colorectum | MSS | positive regulation of lamellipodium organization | 18/3467 | 37/18723 | 2.97e-05 | 6.02e-04 | 18 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00975812 | Colorectum | MSS | lamellipodium organization | 33/3467 | 90/18723 | 3.70e-05 | 7.09e-04 | 33 |
GO:00423262 | Colorectum | MSS | negative regulation of phosphorylation | 103/3467 | 385/18723 | 3.76e-05 | 7.17e-04 | 103 |
GO:00019332 | Colorectum | MSS | negative regulation of protein phosphorylation | 93/3467 | 342/18723 | 4.54e-05 | 8.35e-04 | 93 |
GO:00602492 | Colorectum | MSS | anatomical structure homeostasis | 84/3467 | 314/18723 | 1.87e-04 | 2.64e-03 | 84 |
GO:00432972 | Colorectum | MSS | apical junction assembly | 28/3467 | 78/18723 | 2.12e-04 | 2.95e-03 | 28 |
GO:00105922 | Colorectum | MSS | positive regulation of lamellipodium assembly | 14/3467 | 29/18723 | 2.54e-04 | 3.42e-03 | 14 |
GO:00018942 | Colorectum | MSS | tissue homeostasis | 72/3467 | 268/18723 | 4.53e-04 | 5.40e-03 | 72 |
GO:00105912 | Colorectum | MSS | regulation of lamellipodium assembly | 17/3467 | 42/18723 | 7.63e-04 | 8.10e-03 | 17 |
GO:01201932 | Colorectum | MSS | tight junction organization | 27/3467 | 80/18723 | 8.31e-04 | 8.68e-03 | 27 |
GO:01201922 | Colorectum | MSS | tight junction assembly | 25/3467 | 74/18723 | 1.25e-03 | 1.20e-02 | 25 |
GO:01200322 | Colorectum | MSS | regulation of plasma membrane bounded cell projection assembly | 51/3467 | 186/18723 | 1.78e-03 | 1.58e-02 | 51 |
GO:00300321 | Colorectum | MSS | lamellipodium assembly | 24/3467 | 72/18723 | 1.91e-03 | 1.66e-02 | 24 |
GO:0034764 | Colorectum | MSS | positive regulation of transmembrane transport | 58/3467 | 219/18723 | 2.19e-03 | 1.83e-02 | 58 |
GO:00604911 | Colorectum | MSS | regulation of cell projection assembly | 51/3467 | 188/18723 | 2.28e-03 | 1.87e-02 | 51 |
GO:00708302 | Colorectum | MSS | bicellular tight junction assembly | 22/3467 | 70/18723 | 6.42e-03 | 4.27e-02 | 22 |
GO:01200341 | Colorectum | MSS | positive regulation of plasma membrane bounded cell projection assembly | 30/3467 | 105/18723 | 7.74e-03 | 4.84e-02 | 30 |
GO:00343293 | Colorectum | FAP | cell junction assembly | 105/2622 | 420/18723 | 1.03e-09 | 2.18e-07 | 105 |
GO:00452164 | Colorectum | FAP | cell-cell junction organization | 58/2622 | 200/18723 | 2.51e-08 | 2.36e-06 | 58 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04530 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa05130 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa05160 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa04670 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045301 | Colorectum | AD | Tight junction | 76/2092 | 169/8465 | 5.49e-09 | 9.69e-08 | 6.18e-08 | 76 |
hsa051301 | Colorectum | AD | Pathogenic Escherichia coli infection | 79/2092 | 197/8465 | 1.05e-06 | 1.36e-05 | 8.65e-06 | 79 |
hsa051601 | Colorectum | AD | Hepatitis C | 54/2092 | 157/8465 | 3.87e-03 | 1.96e-02 | 1.25e-02 | 54 |
hsa046701 | Colorectum | AD | Leukocyte transendothelial migration | 41/2092 | 114/8465 | 4.60e-03 | 2.20e-02 | 1.40e-02 | 41 |
hsa045302 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa051302 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa046702 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa045303 | Colorectum | SER | Tight junction | 59/1580 | 169/8465 | 3.24e-07 | 5.98e-06 | 4.34e-06 | 59 |
hsa051303 | Colorectum | SER | Pathogenic Escherichia coli infection | 60/1580 | 197/8465 | 3.63e-05 | 4.31e-04 | 3.13e-04 | 60 |
hsa046703 | Colorectum | SER | Leukocyte transendothelial migration | 37/1580 | 114/8465 | 2.77e-04 | 2.56e-03 | 1.86e-03 | 37 |
hsa045304 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa051304 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
hsa051602 | Colorectum | MSS | Hepatitis C | 52/1875 | 157/8465 | 9.29e-04 | 5.58e-03 | 3.42e-03 | 52 |
hsa046704 | Colorectum | MSS | Leukocyte transendothelial migration | 36/1875 | 114/8465 | 1.21e-02 | 4.02e-02 | 2.46e-02 | 36 |
hsa045305 | Colorectum | MSS | Tight junction | 66/1875 | 169/8465 | 4.10e-07 | 6.25e-06 | 3.83e-06 | 66 |
hsa051305 | Colorectum | MSS | Pathogenic Escherichia coli infection | 73/1875 | 197/8465 | 1.10e-06 | 1.48e-05 | 9.06e-06 | 73 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | AD |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | ADJ |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | CRC |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | FAP |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | Healthy |
OCLN | OCLN | OCLN_OCLN | OCLN | CRC | MSI-H |
OCLN | OCLN | OCLN_OCLN | OCLN | Endometrium | AEH |
OCLN | OCLN | OCLN_OCLN | OCLN | Endometrium | EEC |
OCLN | OCLN | OCLN_OCLN | OCLN | GC | ADJ |
OCLN | OCLN | OCLN_OCLN | OCLN | HNSCC | ADJ |
OCLN | OCLN | OCLN_OCLN | OCLN | HNSCC | OSCC |
OCLN | OCLN | OCLN_OCLN | OCLN | HNSCC | Precancer |
OCLN | OCLN | OCLN_OCLN | OCLN | Liver | HCC |
OCLN | OCLN | OCLN_OCLN | OCLN | Liver | Healthy |
OCLN | OCLN | OCLN_OCLN | OCLN | Liver | Precancer |
OCLN | OCLN | OCLN_OCLN | OCLN | Lung | AAH |
OCLN | OCLN | OCLN_OCLN | OCLN | Lung | IAC |
OCLN | OCLN | OCLN_OCLN | OCLN | Lung | MIAC |
OCLN | OCLN | OCLN_OCLN | OCLN | Prostate | BPH |
OCLN | OCLN | OCLN_OCLN | OCLN | Prostate | Healthy |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OCLN | SNV | Missense_Mutation | rs753783440 | c.1243N>A | p.Asp415Asn | p.D415N | Q16625 | protein_coding | tolerated(0.12) | benign(0.376) | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
OCLN | SNV | Missense_Mutation | c.8N>G | p.Ser3Cys | p.S3C | Q16625 | protein_coding | deleterious(0.01) | possibly_damaging(0.499) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
OCLN | SNV | Missense_Mutation | c.874N>A | p.Pro292Thr | p.P292T | Q16625 | protein_coding | deleterious(0.01) | possibly_damaging(0.625) | TCGA-E2-A14Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD | |
OCLN | insertion | Frame_Shift_Ins | novel | c.581_582insGTGC | p.Ile194MetfsTer83 | p.I194Mfs*83 | Q16625 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
OCLN | insertion | In_Frame_Ins | novel | c.582_583insCTTTCTTATACATTCTCATTTAAT | p.Ile194_Met195insLeuSerTyrThrPheSerPheAsn | p.I194_M195insLSYTFSFN | Q16625 | protein_coding | TCGA-A8-A06X-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
OCLN | SNV | Missense_Mutation | c.1239N>T | p.Glu413Asp | p.E413D | Q16625 | protein_coding | tolerated(0.96) | benign(0.007) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
OCLN | SNV | Missense_Mutation | novel | c.125N>T | p.Pro42Leu | p.P42L | Q16625 | protein_coding | deleterious(0.04) | possibly_damaging(0.71) | TCGA-AA-3855-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OCLN | SNV | Missense_Mutation | novel | c.250G>A | p.Ala84Thr | p.A84T | Q16625 | protein_coding | deleterious(0.01) | benign(0.358) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
OCLN | SNV | Missense_Mutation | novel | c.172T>A | p.Trp58Arg | p.W58R | Q16625 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
OCLN | SNV | Missense_Mutation | c.880N>A | p.Val294Ile | p.V294I | Q16625 | protein_coding | tolerated(0.05) | possibly_damaging(0.695) | TCGA-DY-A0XA-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | mayo | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
100506658 | OCLN | DRUGGABLE GENOME, TRANSPORTER | RETINOIC ACID | 15500294 |
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