Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
Thyroid | | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis |
PTC: Papillary thyroid cancer |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0009896110 | Oral cavity | LP | positive regulation of catabolic process | 187/4623 | 492/18723 | 2.30e-11 | 1.58e-09 | 187 |
GO:0045732110 | Oral cavity | LP | positive regulation of protein catabolic process | 103/4623 | 231/18723 | 2.68e-11 | 1.81e-09 | 103 |
GO:1904951110 | Oral cavity | LP | positive regulation of establishment of protein localization | 132/4623 | 319/18723 | 3.06e-11 | 2.00e-09 | 132 |
GO:009031615 | Oral cavity | LP | positive regulation of intracellular protein transport | 78/4623 | 160/18723 | 3.53e-11 | 2.28e-09 | 78 |
GO:0051222110 | Oral cavity | LP | positive regulation of protein transport | 123/4623 | 303/18723 | 6.05e-10 | 2.96e-08 | 123 |
GO:000659512 | Oral cavity | LP | polyamine metabolic process | 13/4623 | 18/18723 | 2.94e-05 | 4.58e-04 | 13 |
GO:000659612 | Oral cavity | LP | polyamine biosynthetic process | 10/4623 | 14/18723 | 3.05e-04 | 3.12e-03 | 10 |
GO:004217629 | Skin | cSCC | regulation of protein catabolic process | 198/4864 | 391/18723 | 6.03e-26 | 1.89e-23 | 198 |
GO:0032386110 | Skin | cSCC | regulation of intracellular transport | 156/4864 | 337/18723 | 4.48e-16 | 3.96e-14 | 156 |
GO:003315724 | Skin | cSCC | regulation of intracellular protein transport | 115/4864 | 229/18723 | 2.74e-15 | 2.23e-13 | 115 |
GO:000989628 | Skin | cSCC | positive regulation of catabolic process | 206/4864 | 492/18723 | 6.06e-15 | 4.64e-13 | 206 |
GO:004573229 | Skin | cSCC | positive regulation of protein catabolic process | 112/4864 | 231/18723 | 1.37e-13 | 8.40e-12 | 112 |
GO:0032388111 | Skin | cSCC | positive regulation of intracellular transport | 96/4864 | 202/18723 | 3.14e-11 | 1.52e-09 | 96 |
GO:009031623 | Skin | cSCC | positive regulation of intracellular protein transport | 79/4864 | 160/18723 | 1.71e-10 | 7.52e-09 | 79 |
GO:1904951112 | Skin | cSCC | positive regulation of establishment of protein localization | 134/4864 | 319/18723 | 2.60e-10 | 1.09e-08 | 134 |
GO:0051222112 | Skin | cSCC | positive regulation of protein transport | 125/4864 | 303/18723 | 3.88e-09 | 1.32e-07 | 125 |
GO:000659513 | Skin | cSCC | polyamine metabolic process | 11/4864 | 18/18723 | 1.74e-03 | 1.06e-02 | 11 |
GO:000659621 | Skin | cSCC | polyamine biosynthetic process | 9/4864 | 14/18723 | 2.87e-03 | 1.60e-02 | 9 |
GO:0009896113 | Thyroid | PTC | positive regulation of catabolic process | 278/5968 | 492/18723 | 3.35e-30 | 2.64e-27 | 278 |
GO:0042176113 | Thyroid | PTC | regulation of protein catabolic process | 231/5968 | 391/18723 | 4.76e-29 | 2.14e-26 | 231 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
OAZ2 | SNV | Missense_Mutation | | c.18N>A | p.Asp6Glu | p.D6E | O95190 | protein_coding | tolerated(1) | benign(0.417) | TCGA-A8-A07G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | 5-fluorouracil | CR |
OAZ2 | deletion | Frame_Shift_Del | novel | c.77delN | p.Pro26GlnfsTer31 | p.P26Qfs*31 | O95190 | protein_coding | | | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
OAZ2 | SNV | Missense_Mutation | | c.521N>C | p.Val174Ala | p.V174A | O95190 | protein_coding | tolerated(0.64) | benign(0.018) | TCGA-AY-6197-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
OAZ2 | SNV | Missense_Mutation | rs369960638 | c.181N>A | p.Glu61Lys | p.E61K | O95190 | protein_coding | tolerated(0.48) | benign(0.163) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
OAZ2 | SNV | Missense_Mutation | novel | c.223N>C | p.Lys75Gln | p.K75Q | O95190 | protein_coding | tolerated(0.07) | benign(0.037) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OAZ2 | SNV | Missense_Mutation | novel | c.202G>T | p.Asp68Tyr | p.D68Y | O95190 | protein_coding | deleterious(0.01) | possibly_damaging(0.907) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OAZ2 | SNV | Missense_Mutation | novel | c.419N>A | p.Arg140Lys | p.R140K | O95190 | protein_coding | tolerated(0.27) | benign(0.246) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
OAZ2 | SNV | Missense_Mutation | novel | c.549G>T | p.Gln183His | p.Q183H | O95190 | protein_coding | deleterious(0) | benign(0.059) | TCGA-AX-A2HC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | PD |
OAZ2 | SNV | Missense_Mutation | novel | c.27N>G | p.Ile9Met | p.I9M | O95190 | protein_coding | tolerated(0.13) | benign(0.374) | TCGA-DF-A2KN-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
OAZ2 | SNV | Missense_Mutation | novel | c.296G>T | p.Ser99Ile | p.S99I | O95190 | protein_coding | deleterious(0.01) | benign(0.14) | TCGA-DF-A2KU-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |