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Gene: NXN |
Gene summary for NXN |
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Gene information | Species | Human | Gene symbol | NXN | Gene ID | 64359 |
Gene name | nucleoredoxin | |
Gene Alias | NRX | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q6DKJ4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64359 | NXN | CA_HPV_1 | Human | Cervix | CC | 6.02e-05 | -1.57e-01 | 0.0264 |
64359 | NXN | CCI_1 | Human | Cervix | CC | 3.50e-18 | 1.42e+00 | 0.528 |
64359 | NXN | CCI_2 | Human | Cervix | CC | 3.61e-05 | 6.87e-01 | 0.5249 |
64359 | NXN | CCI_3 | Human | Cervix | CC | 5.40e-04 | 6.85e-01 | 0.516 |
64359 | NXN | AEH-subject2 | Human | Endometrium | AEH | 1.55e-07 | 2.60e-01 | -0.2525 |
64359 | NXN | AEH-subject3 | Human | Endometrium | AEH | 1.28e-05 | 1.67e-01 | -0.2576 |
64359 | NXN | AEH-subject4 | Human | Endometrium | AEH | 3.74e-29 | 8.53e-01 | -0.2657 |
64359 | NXN | AEH-subject5 | Human | Endometrium | AEH | 1.33e-05 | 2.36e-01 | -0.2953 |
64359 | NXN | EEC-subject1 | Human | Endometrium | EEC | 3.98e-14 | 4.76e-01 | -0.2682 |
64359 | NXN | EEC-subject2 | Human | Endometrium | EEC | 1.47e-04 | 2.59e-01 | -0.2607 |
64359 | NXN | EEC-subject3 | Human | Endometrium | EEC | 5.60e-16 | 2.55e-01 | -0.2525 |
64359 | NXN | GSM5276935 | Human | Endometrium | EEC | 9.13e-07 | -2.03e-01 | -0.123 |
64359 | NXN | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.98e-13 | -2.01e-01 | -0.1869 |
64359 | NXN | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 1.10e-20 | -2.04e-01 | -0.1875 |
64359 | NXN | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 1.73e-14 | -2.15e-01 | -0.1883 |
64359 | NXN | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 2.08e-17 | -1.68e-01 | -0.1934 |
64359 | NXN | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 8.49e-18 | -6.75e-02 | -0.1917 |
64359 | NXN | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 5.15e-22 | -7.48e-02 | -0.1916 |
64359 | NXN | LZE22T | Human | Esophagus | ESCC | 2.91e-02 | 3.54e-01 | 0.068 |
64359 | NXN | LZE24T | Human | Esophagus | ESCC | 6.49e-08 | 1.44e-01 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190332113 | Lung | AIS | negative regulation of protein modification by small protein conjugation or removal | 24/1849 | 95/18723 | 1.22e-05 | 4.71e-04 | 24 |
GO:003139713 | Lung | AIS | negative regulation of protein ubiquitination | 22/1849 | 83/18723 | 1.22e-05 | 4.71e-04 | 22 |
GO:000170112 | Lung | AIS | in utero embryonic development | 59/1849 | 367/18723 | 1.20e-04 | 2.75e-03 | 59 |
GO:003017811 | Lung | AIS | negative regulation of Wnt signaling pathway | 32/1849 | 170/18723 | 2.64e-04 | 5.05e-03 | 32 |
GO:003011122 | Lung | MIAC | regulation of Wnt signaling pathway | 41/967 | 328/18723 | 1.51e-07 | 3.69e-05 | 41 |
GO:003139723 | Lung | MIAC | negative regulation of protein ubiquitination | 18/967 | 83/18723 | 1.81e-07 | 4.02e-05 | 18 |
GO:001605531 | Lung | MIAC | Wnt signaling pathway | 50/967 | 444/18723 | 1.88e-07 | 4.02e-05 | 50 |
GO:019873831 | Lung | MIAC | cell-cell signaling by wnt | 50/967 | 446/18723 | 2.16e-07 | 4.11e-05 | 50 |
GO:190332133 | Lung | MIAC | negative regulation of protein modification by small protein conjugation or removal | 19/967 | 95/18723 | 3.20e-07 | 5.66e-05 | 19 |
GO:190332023 | Lung | MIAC | regulation of protein modification by small protein conjugation or removal | 32/967 | 242/18723 | 1.01e-06 | 1.40e-04 | 32 |
GO:003139623 | Lung | MIAC | regulation of protein ubiquitination | 25/967 | 210/18723 | 8.79e-05 | 3.92e-03 | 25 |
GO:00301782 | Lung | MIAC | negative regulation of Wnt signaling pathway | 19/967 | 170/18723 | 1.28e-03 | 2.38e-02 | 19 |
GO:000170131 | Lung | MIAC | in utero embryonic development | 33/967 | 367/18723 | 1.44e-03 | 2.54e-02 | 33 |
GO:190332020 | Oral cavity | OSCC | regulation of protein modification by small protein conjugation or removal | 165/7305 | 242/18723 | 2.52e-20 | 3.99e-18 | 165 |
GO:003139620 | Oral cavity | OSCC | regulation of protein ubiquitination | 143/7305 | 210/18723 | 1.01e-17 | 9.80e-16 | 143 |
GO:000170116 | Oral cavity | OSCC | in utero embryonic development | 207/7305 | 367/18723 | 7.92e-12 | 2.95e-10 | 207 |
GO:003139720 | Oral cavity | OSCC | negative regulation of protein ubiquitination | 61/7305 | 83/18723 | 1.78e-10 | 5.17e-09 | 61 |
GO:190332120 | Oral cavity | OSCC | negative regulation of protein modification by small protein conjugation or removal | 65/7305 | 95/18723 | 5.88e-09 | 1.26e-07 | 65 |
GO:001605510 | Oral cavity | OSCC | Wnt signaling pathway | 227/7305 | 444/18723 | 1.10e-07 | 1.87e-06 | 227 |
GO:019873810 | Oral cavity | OSCC | cell-cell signaling by wnt | 227/7305 | 446/18723 | 1.75e-07 | 2.86e-06 | 227 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NXN | SNV | Missense_Mutation | novel | c.464N>A | p.Arg155Gln | p.R155Q | Q6DKJ4 | protein_coding | tolerated(0.21) | probably_damaging(0.945) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
NXN | SNV | Missense_Mutation | c.600N>A | p.Phe200Leu | p.F200L | Q6DKJ4 | protein_coding | deleterious(0.04) | probably_damaging(0.977) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NXN | SNV | Missense_Mutation | novel | c.1165N>T | p.Pro389Ser | p.P389S | Q6DKJ4 | protein_coding | tolerated(0.22) | probably_damaging(0.999) | TCGA-OL-A66J-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
NXN | SNV | Missense_Mutation | novel | c.1205N>T | p.Ala402Val | p.A402V | Q6DKJ4 | protein_coding | tolerated(0.12) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NXN | SNV | Missense_Mutation | c.383G>A | p.Arg128Gln | p.R128Q | Q6DKJ4 | protein_coding | deleterious(0.02) | benign(0.278) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
NXN | SNV | Missense_Mutation | c.600N>A | p.Phe200Leu | p.F200L | Q6DKJ4 | protein_coding | deleterious(0.04) | probably_damaging(0.977) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
NXN | SNV | Missense_Mutation | c.529C>T | p.Pro177Ser | p.P177S | Q6DKJ4 | protein_coding | tolerated(0.33) | probably_damaging(0.986) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
NXN | SNV | Missense_Mutation | novel | c.1226N>G | p.Asp409Gly | p.D409G | Q6DKJ4 | protein_coding | tolerated(0.1) | probably_damaging(0.997) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
NXN | SNV | Missense_Mutation | rs201764402 | c.604N>A | p.Ala202Thr | p.A202T | Q6DKJ4 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
NXN | SNV | Missense_Mutation | novel | c.860T>C | p.Val287Ala | p.V287A | Q6DKJ4 | protein_coding | deleterious(0.03) | benign(0.197) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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