Tissue | Expression Dynamics | Abbreviation |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/NDFIP2_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/NDFIP2_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Esophagus | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Esophagus/NDFIP2_pca_on_diff_genes.png) | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias |
LGIN: Low-grade intraepithelial neoplasias |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/NDFIP2_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Oral Cavity | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/OralCavity/NDFIP2_pca_on_diff_genes.png) | EOLP: Erosive Oral lichen planus |
LP: leukoplakia |
NEOLP: Non-erosive oral lichen planus |
OSCC: Oral squamous cell carcinoma |
Skin | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Skin/NDFIP2_pca_on_diff_genes.png) | AK: Actinic keratosis |
cSCC: Cutaneous squamous cell carcinoma |
SCCIS:squamous cell carcinoma in situ |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000703415 | Oral cavity | LP | vacuolar transport | 74/4623 | 157/18723 | 7.85e-10 | 3.70e-08 | 74 |
GO:004312219 | Oral cavity | LP | regulation of I-kappaB kinase/NF-kappaB signaling | 103/4623 | 249/18723 | 4.48e-09 | 1.90e-07 | 103 |
GO:000724917 | Oral cavity | LP | I-kappaB kinase/NF-kappaB signaling | 110/4623 | 281/18723 | 4.94e-08 | 1.70e-06 | 110 |
GO:190332215 | Oral cavity | LP | positive regulation of protein modification by small protein conjugation or removal | 57/4623 | 138/18723 | 1.24e-05 | 2.23e-04 | 57 |
GO:003139815 | Oral cavity | LP | positive regulation of protein ubiquitination | 47/4623 | 119/18723 | 2.46e-04 | 2.60e-03 | 47 |
GO:190495012 | Oral cavity | LP | negative regulation of establishment of protein localization | 47/4623 | 131/18723 | 2.73e-03 | 1.92e-02 | 47 |
GO:005122412 | Oral cavity | LP | negative regulation of protein transport | 45/4623 | 127/18723 | 4.33e-03 | 2.78e-02 | 45 |
GO:190332028 | Skin | AK | regulation of protein modification by small protein conjugation or removal | 62/1910 | 242/18723 | 4.90e-12 | 1.04e-09 | 62 |
GO:003139628 | Skin | AK | regulation of protein ubiquitination | 54/1910 | 210/18723 | 9.94e-11 | 1.55e-08 | 54 |
GO:004312224 | Skin | AK | regulation of I-kappaB kinase/NF-kappaB signaling | 42/1910 | 249/18723 | 7.65e-04 | 6.39e-03 | 42 |
GO:000724920 | Skin | AK | I-kappaB kinase/NF-kappaB signaling | 46/1910 | 281/18723 | 8.56e-04 | 7.08e-03 | 46 |
GO:19033229 | Skin | AK | positive regulation of protein modification by small protein conjugation or removal | 25/1910 | 138/18723 | 3.18e-03 | 1.95e-02 | 25 |
GO:004312319 | Skin | AK | positive regulation of I-kappaB kinase/NF-kappaB signaling | 31/1910 | 186/18723 | 4.21e-03 | 2.46e-02 | 31 |
GO:000703418 | Skin | AK | vacuolar transport | 27/1910 | 157/18723 | 4.70e-03 | 2.69e-02 | 27 |
GO:00313988 | Skin | AK | positive regulation of protein ubiquitination | 21/1910 | 119/18723 | 8.77e-03 | 4.32e-02 | 21 |
GO:190332029 | Skin | cSCC | regulation of protein modification by small protein conjugation or removal | 125/4864 | 242/18723 | 9.50e-18 | 1.05e-15 | 125 |
GO:003139629 | Skin | cSCC | regulation of protein ubiquitination | 107/4864 | 210/18723 | 7.17e-15 | 5.35e-13 | 107 |
GO:000703419 | Skin | cSCC | vacuolar transport | 74/4864 | 157/18723 | 8.60e-09 | 2.72e-07 | 74 |
GO:0043123110 | Skin | cSCC | positive regulation of I-kappaB kinase/NF-kappaB signaling | 84/4864 | 186/18723 | 1.09e-08 | 3.40e-07 | 84 |
GO:000724925 | Skin | cSCC | I-kappaB kinase/NF-kappaB signaling | 116/4864 | 281/18723 | 1.33e-08 | 4.08e-07 | 116 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
NDFIP2 | SNV | Missense_Mutation | | c.203N>T | p.Thr68Met | p.T68M | Q9NV92 | protein_coding | deleterious_low_confidence(0) | benign(0.01) | TCGA-AO-A0J9-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | PD |
NDFIP2 | SNV | Missense_Mutation | | c.943N>G | p.Leu315Val | p.L315V | Q9NV92 | protein_coding | tolerated(0.12) | probably_damaging(0.999) | TCGA-AR-A0TX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDFIP2 | SNV | Missense_Mutation | rs754913477 | c.341N>T | p.Asn114Ile | p.N114I | Q9NV92 | protein_coding | deleterious(0.01) | benign(0.11) | TCGA-PL-A8LZ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
NDFIP2 | insertion | Frame_Shift_Ins | novel | c.765_766insTTGCTCTGTTGCCC | p.Asn256LeufsTer8 | p.N256Lfs*8 | Q9NV92 | protein_coding | | | TCGA-B6-A0IA-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDFIP2 | SNV | Missense_Mutation | novel | c.872N>A | p.Gly291Glu | p.G291E | Q9NV92 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-VS-A94W-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
NDFIP2 | deletion | In_Frame_Del | novel | c.826_828delNNN | p.Ile276del | p.I276del | Q9NV92 | protein_coding | | | TCGA-BI-A20A-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
NDFIP2 | SNV | Missense_Mutation | rs775126701 | c.517N>A | p.Val173Met | p.V173M | Q9NV92 | protein_coding | deleterious(0.01) | probably_damaging(0.961) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
NDFIP2 | SNV | Missense_Mutation | | c.353N>T | p.Ser118Leu | p.S118L | Q9NV92 | protein_coding | deleterious(0.03) | benign(0) | TCGA-AH-6544-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | oxaliplatin | SD |
NDFIP2 | insertion | In_Frame_Ins | novel | c.829_830insTTATTGTCAGGGTGAGTGTCT | p.Arg280_Phe281insValSerValPheIleValArg | p.R280_F281insVSVFIVR | Q9NV92 | protein_coding | | | TCGA-F4-6809-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
NDFIP2 | SNV | Missense_Mutation | novel | c.932T>G | p.Phe311Cys | p.F311C | Q9NV92 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |