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Gene: MRPS2 |
Gene summary for MRPS2 |
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Gene information | Species | Human | Gene symbol | MRPS2 | Gene ID | 51116 |
Gene name | mitochondrial ribosomal protein S2 | |
Gene Alias | CGI-91 | |
Cytomap | 9q34.3 | |
Gene Type | protein-coding | GO ID | GO:0006412 | UniProtAcc | Q9Y399 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51116 | MRPS2 | HTA11_3410_2000001011 | Human | Colorectum | AD | 2.24e-02 | 9.32e-02 | 0.0155 |
51116 | MRPS2 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.42e-02 | 2.02e-01 | -0.1808 |
51116 | MRPS2 | HTA11_1938_2000001011 | Human | Colorectum | AD | 1.05e-03 | 2.13e-01 | -0.0811 |
51116 | MRPS2 | HTA11_347_2000001011 | Human | Colorectum | AD | 1.69e-06 | 1.75e-01 | -0.1954 |
51116 | MRPS2 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.63e-03 | 1.83e-01 | -0.1207 |
51116 | MRPS2 | HTA11_696_2000001011 | Human | Colorectum | AD | 1.39e-05 | 1.52e-01 | -0.1464 |
51116 | MRPS2 | HTA11_866_2000001011 | Human | Colorectum | AD | 1.87e-03 | 1.34e-01 | -0.1001 |
51116 | MRPS2 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.76e-11 | 4.33e-01 | -0.059 |
51116 | MRPS2 | HTA11_866_3004761011 | Human | Colorectum | AD | 3.67e-20 | 4.79e-01 | 0.096 |
51116 | MRPS2 | HTA11_4255_2000001011 | Human | Colorectum | SER | 9.56e-04 | 2.78e-01 | 0.0446 |
51116 | MRPS2 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.15e-07 | 3.16e-01 | 0.0528 |
51116 | MRPS2 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.27e-03 | 3.77e-01 | 0.0131 |
51116 | MRPS2 | HTA11_10623_2000001011 | Human | Colorectum | AD | 8.27e-03 | 2.70e-01 | -0.0177 |
51116 | MRPS2 | HTA11_6801_2000001011 | Human | Colorectum | SER | 4.24e-07 | 5.43e-01 | 0.0171 |
51116 | MRPS2 | HTA11_10711_2000001011 | Human | Colorectum | AD | 9.06e-09 | 2.98e-01 | 0.0338 |
51116 | MRPS2 | HTA11_7696_3000711011 | Human | Colorectum | AD | 2.62e-21 | 4.82e-01 | 0.0674 |
51116 | MRPS2 | HTA11_7469_2000001011 | Human | Colorectum | AD | 3.97e-04 | 4.25e-01 | -0.0124 |
51116 | MRPS2 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.83e-05 | 2.24e-01 | 0.0588 |
51116 | MRPS2 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.69e-18 | 3.63e-01 | 0.294 |
51116 | MRPS2 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.82e-02 | 6.02e-01 | 0.3487 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00427698 | Skin | cSCC | DNA damage response, detection of DNA damage | 10/4864 | 13/18723 | 1.78e-04 | 1.50e-03 | 10 |
GO:00701293 | Skin | cSCC | regulation of mitochondrial translation | 13/4864 | 24/18723 | 3.02e-03 | 1.67e-02 | 13 |
GO:00621253 | Skin | cSCC | regulation of mitochondrial gene expression | 14/4864 | 28/18723 | 5.47e-03 | 2.73e-02 | 14 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0042254113 | Thyroid | PTC | ribosome biogenesis | 202/5968 | 299/18723 | 3.47e-37 | 5.47e-34 | 202 |
GO:0042255113 | Thyroid | PTC | ribosome assembly | 43/5968 | 61/18723 | 6.72e-10 | 2.04e-08 | 43 |
GO:01400536 | Thyroid | PTC | mitochondrial gene expression | 51/5968 | 108/18723 | 6.04e-04 | 3.83e-03 | 51 |
GO:00325437 | Thyroid | PTC | mitochondrial translation | 38/5968 | 76/18723 | 7.52e-04 | 4.67e-03 | 38 |
GO:00427699 | Thyroid | PTC | DNA damage response, detection of DNA damage | 10/5968 | 13/18723 | 1.11e-03 | 6.51e-03 | 10 |
GO:002261334 | Thyroid | ATC | ribonucleoprotein complex biogenesis | 292/6293 | 463/18723 | 3.05e-39 | 9.63e-36 | 292 |
GO:004225434 | Thyroid | ATC | ribosome biogenesis | 203/6293 | 299/18723 | 3.63e-34 | 4.59e-31 | 203 |
GO:004225535 | Thyroid | ATC | ribosome assembly | 43/6293 | 61/18723 | 4.24e-09 | 9.57e-08 | 43 |
GO:004276914 | Thyroid | ATC | DNA damage response, detection of DNA damage | 10/6293 | 13/18723 | 1.77e-03 | 8.71e-03 | 10 |
GO:014005314 | Thyroid | ATC | mitochondrial gene expression | 51/6293 | 108/18723 | 2.26e-03 | 1.06e-02 | 51 |
GO:003254315 | Thyroid | ATC | mitochondrial translation | 38/6293 | 76/18723 | 2.26e-03 | 1.06e-02 | 38 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03010 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030101 | Colorectum | AD | Ribosome | 96/2092 | 167/8465 | 8.28e-20 | 5.54e-18 | 3.54e-18 | 96 |
hsa030102 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030103 | Colorectum | SER | Ribosome | 92/1580 | 167/8465 | 2.21e-26 | 3.66e-24 | 2.66e-24 | 92 |
hsa030104 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa030105 | Colorectum | MSS | Ribosome | 96/1875 | 167/8465 | 1.82e-23 | 2.03e-21 | 1.24e-21 | 96 |
hsa030106 | Colorectum | MSI-H | Ribosome | 87/797 | 167/8465 | 5.55e-46 | 1.80e-43 | 1.51e-43 | 87 |
hsa030107 | Colorectum | MSI-H | Ribosome | 87/797 | 167/8465 | 5.55e-46 | 1.80e-43 | 1.51e-43 | 87 |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPS2 | SNV | Missense_Mutation | rs760405762 | c.535G>A | p.Ala179Thr | p.A179T | Q9Y399 | protein_coding | tolerated(0.1) | possibly_damaging(0.84) | TCGA-A7-A4SD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | CR |
MRPS2 | SNV | Missense_Mutation | rs767971399 | c.329N>A | p.Arg110His | p.R110H | Q9Y399 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPS2 | SNV | Missense_Mutation | novel | c.554N>T | p.Pro185Leu | p.P185L | Q9Y399 | protein_coding | deleterious(0.03) | possibly_damaging(0.515) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MRPS2 | SNV | Missense_Mutation | rs201117985 | c.838N>A | p.Gly280Arg | p.G280R | Q9Y399 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
MRPS2 | SNV | Missense_Mutation | rs753018156 | c.412N>T | p.Arg138Cys | p.R138C | Q9Y399 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
MRPS2 | SNV | Missense_Mutation | rs753767783 | c.539N>A | p.Arg180His | p.R180H | Q9Y399 | protein_coding | tolerated(0.37) | benign(0) | TCGA-A6-4105-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MRPS2 | SNV | Missense_Mutation | rs760188552 | c.506N>A | p.Arg169His | p.R169H | Q9Y399 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
MRPS2 | SNV | Missense_Mutation | rs746234639 | c.293N>A | p.Arg98Gln | p.R98Q | Q9Y399 | protein_coding | deleterious(0.03) | probably_damaging(0.971) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD |
MRPS2 | SNV | Missense_Mutation | c.529A>T | p.Thr177Ser | p.T177S | Q9Y399 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPS2 | SNV | Missense_Mutation | rs762097553 | c.712N>A | p.Gly238Ser | p.G238S | Q9Y399 | protein_coding | deleterious(0.03) | probably_damaging(1) | TCGA-CK-5916-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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