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Gene: MRPS11 |
Gene summary for MRPS11 |
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Gene information | Species | Human | Gene symbol | MRPS11 | Gene ID | 64963 |
Gene name | mitochondrial ribosomal protein S11 | |
Gene Alias | HCC-2 | |
Cytomap | 15q25.3 | |
Gene Type | protein-coding | GO ID | GO:0000028 | UniProtAcc | P82912 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64963 | MRPS11 | LZE4T | Human | Esophagus | ESCC | 1.67e-10 | 3.03e-01 | 0.0811 |
64963 | MRPS11 | LZE5T | Human | Esophagus | ESCC | 2.49e-02 | 3.71e-01 | 0.0514 |
64963 | MRPS11 | LZE7T | Human | Esophagus | ESCC | 8.09e-20 | 8.63e-01 | 0.0667 |
64963 | MRPS11 | LZE8T | Human | Esophagus | ESCC | 7.74e-08 | 2.72e-01 | 0.067 |
64963 | MRPS11 | LZE20T | Human | Esophagus | ESCC | 1.69e-02 | 1.45e-01 | 0.0662 |
64963 | MRPS11 | LZE22T | Human | Esophagus | ESCC | 1.05e-03 | 3.71e-01 | 0.068 |
64963 | MRPS11 | LZE24T | Human | Esophagus | ESCC | 3.17e-13 | 3.61e-01 | 0.0596 |
64963 | MRPS11 | LZE21T | Human | Esophagus | ESCC | 1.53e-06 | 5.27e-01 | 0.0655 |
64963 | MRPS11 | LZE6T | Human | Esophagus | ESCC | 3.41e-14 | 5.90e-01 | 0.0845 |
64963 | MRPS11 | P1T-E | Human | Esophagus | ESCC | 6.48e-13 | 5.47e-01 | 0.0875 |
64963 | MRPS11 | P2T-E | Human | Esophagus | ESCC | 2.46e-29 | 5.08e-01 | 0.1177 |
64963 | MRPS11 | P4T-E | Human | Esophagus | ESCC | 1.35e-42 | 8.94e-01 | 0.1323 |
64963 | MRPS11 | P5T-E | Human | Esophagus | ESCC | 3.78e-20 | 2.76e-01 | 0.1327 |
64963 | MRPS11 | P8T-E | Human | Esophagus | ESCC | 7.40e-33 | 6.37e-01 | 0.0889 |
64963 | MRPS11 | P9T-E | Human | Esophagus | ESCC | 5.19e-24 | 6.79e-01 | 0.1131 |
64963 | MRPS11 | P10T-E | Human | Esophagus | ESCC | 2.92e-47 | 7.10e-01 | 0.116 |
64963 | MRPS11 | P11T-E | Human | Esophagus | ESCC | 9.76e-12 | 4.79e-01 | 0.1426 |
64963 | MRPS11 | P12T-E | Human | Esophagus | ESCC | 4.51e-37 | 6.12e-01 | 0.1122 |
64963 | MRPS11 | P15T-E | Human | Esophagus | ESCC | 3.62e-22 | 5.01e-01 | 0.1149 |
64963 | MRPS11 | P16T-E | Human | Esophagus | ESCC | 1.88e-29 | 5.94e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:002261329 | Skin | cSCC | ribonucleoprotein complex biogenesis | 302/4864 | 463/18723 | 5.13e-72 | 3.22e-68 | 302 |
GO:004225428 | Skin | cSCC | ribosome biogenesis | 206/4864 | 299/18723 | 3.33e-55 | 1.04e-51 | 206 |
GO:000636424 | Skin | cSCC | rRNA processing | 156/4864 | 225/18723 | 1.42e-42 | 1.48e-39 | 156 |
GO:001607224 | Skin | cSCC | rRNA metabolic process | 158/4864 | 236/18723 | 4.06e-40 | 2.83e-37 | 158 |
GO:003447017 | Skin | cSCC | ncRNA processing | 215/4864 | 395/18723 | 6.83e-34 | 4.28e-31 | 215 |
GO:007182629 | Skin | cSCC | ribonucleoprotein complex subunit organization | 140/4864 | 227/18723 | 5.54e-30 | 3.16e-27 | 140 |
GO:002261829 | Skin | cSCC | ribonucleoprotein complex assembly | 136/4864 | 220/18723 | 2.60e-29 | 1.25e-26 | 136 |
GO:003466013 | Skin | cSCC | ncRNA metabolic process | 234/4864 | 485/18723 | 1.37e-26 | 4.77e-24 | 234 |
GO:004227429 | Skin | cSCC | ribosomal small subunit biogenesis | 59/4864 | 73/18723 | 1.39e-22 | 2.90e-20 | 59 |
GO:003049012 | Skin | cSCC | maturation of SSU-rRNA | 39/4864 | 50/18723 | 2.04e-14 | 1.40e-12 | 39 |
GO:004225529 | Skin | cSCC | ribosome assembly | 44/4864 | 61/18723 | 5.84e-14 | 3.81e-12 | 44 |
GO:00325436 | Skin | cSCC | mitochondrial translation | 47/4864 | 76/18723 | 4.70e-11 | 2.22e-09 | 47 |
GO:01400535 | Skin | cSCC | mitochondrial gene expression | 56/4864 | 108/18723 | 8.06e-09 | 2.56e-07 | 56 |
GO:000046212 | Skin | cSCC | maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) | 26/4864 | 37/18723 | 2.11e-08 | 6.08e-07 | 26 |
GO:000002829 | Skin | cSCC | ribosomal small subunit assembly | 16/4864 | 19/18723 | 1.77e-07 | 3.93e-06 | 16 |
GO:00427698 | Skin | cSCC | DNA damage response, detection of DNA damage | 10/4864 | 13/18723 | 1.78e-04 | 1.50e-03 | 10 |
GO:0022613113 | Thyroid | PTC | ribonucleoprotein complex biogenesis | 292/5968 | 463/18723 | 3.24e-44 | 2.05e-40 | 292 |
GO:0042254113 | Thyroid | PTC | ribosome biogenesis | 202/5968 | 299/18723 | 3.47e-37 | 5.47e-34 | 202 |
GO:0006364112 | Thyroid | PTC | rRNA processing | 156/5968 | 225/18723 | 5.58e-31 | 5.03e-28 | 156 |
GO:0016072112 | Thyroid | PTC | rRNA metabolic process | 160/5968 | 236/18723 | 5.68e-30 | 3.58e-27 | 160 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa03010211 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa03010310 | Esophagus | ESCC | Ribosome | 129/4205 | 167/8465 | 1.43e-13 | 3.43e-12 | 1.75e-12 | 129 |
hsa0301022 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301032 | Liver | Cirrhotic | Ribosome | 127/2530 | 167/8465 | 2.12e-35 | 7.06e-33 | 4.35e-33 | 127 |
hsa0301042 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301052 | Liver | HCC | Ribosome | 128/4020 | 167/8465 | 7.32e-15 | 2.23e-13 | 1.24e-13 | 128 |
hsa0301030 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010114 | Oral cavity | OSCC | Ribosome | 128/3704 | 167/8465 | 2.42e-18 | 1.62e-16 | 8.25e-17 | 128 |
hsa03010210 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
hsa0301038 | Oral cavity | LP | Ribosome | 127/2418 | 167/8465 | 1.22e-37 | 4.05e-35 | 2.61e-35 | 127 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MRPS11 | insertion | Nonsense_Mutation | novel | c.149_150insCCCACCGCCTCTTGTATTTCCTTCTTAACATTCATC | p.Glu50delinsAspProProProLeuValPheProSerTerHisSerSer | p.E50delinsDPPPLVFPS*HSS | P82912 | protein_coding | TCGA-AN-A049-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
MRPS11 | SNV | Missense_Mutation | rs774896757 | c.353N>A | p.Arg118Gln | p.R118Q | P82912 | protein_coding | tolerated(0.14) | benign(0.188) | TCGA-AA-3877-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MRPS11 | SNV | Missense_Mutation | rs149047976 | c.352N>T | p.Arg118Trp | p.R118W | P82912 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPS11 | SNV | Missense_Mutation | rs372417211 | c.490N>A | p.Gly164Arg | p.G164R | P82912 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
MRPS11 | SNV | Missense_Mutation | c.187T>C | p.Tyr63His | p.Y63H | P82912 | protein_coding | tolerated(0.12) | possibly_damaging(0.535) | TCGA-G4-6303-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD | |
MRPS11 | SNV | Missense_Mutation | rs149047976 | c.352C>T | p.Arg118Trp | p.R118W | P82912 | protein_coding | deleterious(0) | probably_damaging(0.983) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPS11 | SNV | Missense_Mutation | c.305N>A | p.Ala102Asp | p.A102D | P82912 | protein_coding | tolerated(0.22) | possibly_damaging(0.521) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MRPS11 | SNV | Missense_Mutation | novel | c.152N>G | p.Gln51Arg | p.Q51R | P82912 | protein_coding | tolerated(0.18) | benign(0) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MRPS11 | SNV | Missense_Mutation | rs372417211 | c.490N>A | p.Gly164Arg | p.G164R | P82912 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A1C5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | SD |
MRPS11 | SNV | Missense_Mutation | novel | c.578N>C | p.Lys193Thr | p.K193T | P82912 | protein_coding | deleterious(0) | benign(0.105) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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