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Gene: LSM14A |
Gene summary for LSM14A |
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Gene information | Species | Human | Gene symbol | LSM14A | Gene ID | 26065 |
Gene name | LSM14A mRNA processing body assembly factor | |
Gene Alias | C19orf13 | |
Cytomap | 19q13.11 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | Q8ND56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26065 | LSM14A | CA_HPV_3 | Human | Cervix | CC | 1.29e-02 | 1.01e-01 | 0.0414 |
26065 | LSM14A | CCI_1 | Human | Cervix | CC | 1.72e-02 | 4.84e-01 | 0.528 |
26065 | LSM14A | CCI_2 | Human | Cervix | CC | 2.28e-06 | 7.43e-01 | 0.5249 |
26065 | LSM14A | CCI_3 | Human | Cervix | CC | 2.90e-04 | 6.28e-01 | 0.516 |
26065 | LSM14A | HTA11_3410_2000001011 | Human | Colorectum | AD | 3.75e-09 | -4.16e-01 | 0.0155 |
26065 | LSM14A | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.83e-02 | 4.43e-01 | 0.281 |
26065 | LSM14A | A001-C-207 | Human | Colorectum | FAP | 1.10e-03 | -2.48e-01 | 0.1278 |
26065 | LSM14A | A015-C-203 | Human | Colorectum | FAP | 1.51e-26 | -4.68e-01 | -0.1294 |
26065 | LSM14A | A015-C-204 | Human | Colorectum | FAP | 3.00e-08 | -2.24e-01 | -0.0228 |
26065 | LSM14A | A014-C-040 | Human | Colorectum | FAP | 8.16e-07 | -5.55e-01 | -0.1184 |
26065 | LSM14A | A002-C-201 | Human | Colorectum | FAP | 4.07e-16 | -3.64e-01 | 0.0324 |
26065 | LSM14A | A002-C-203 | Human | Colorectum | FAP | 1.04e-05 | -1.76e-01 | 0.2786 |
26065 | LSM14A | A001-C-119 | Human | Colorectum | FAP | 2.04e-08 | -3.36e-01 | -0.1557 |
26065 | LSM14A | A001-C-108 | Human | Colorectum | FAP | 4.55e-19 | -3.33e-01 | -0.0272 |
26065 | LSM14A | A002-C-205 | Human | Colorectum | FAP | 2.57e-26 | -4.64e-01 | -0.1236 |
26065 | LSM14A | A014-C-108 | Human | Colorectum | FAP | 2.75e-03 | -4.01e-01 | -0.124 |
26065 | LSM14A | A001-C-104 | Human | Colorectum | FAP | 2.27e-09 | -3.63e-01 | 0.0184 |
26065 | LSM14A | A015-C-005 | Human | Colorectum | FAP | 2.26e-07 | -3.65e-01 | -0.0336 |
26065 | LSM14A | A015-C-006 | Human | Colorectum | FAP | 4.76e-18 | -4.91e-01 | -0.0994 |
26065 | LSM14A | A015-C-106 | Human | Colorectum | FAP | 3.04e-11 | -2.80e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:014001414 | Esophagus | ESCC | mitotic nuclear division | 218/8552 | 287/18723 | 6.17e-26 | 1.78e-23 | 218 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:190285015 | Esophagus | ESCC | microtubule cytoskeleton organization involved in mitosis | 116/8552 | 147/18723 | 1.25e-16 | 9.91e-15 | 116 |
GO:000705214 | Esophagus | ESCC | mitotic spindle organization | 97/8552 | 120/18723 | 2.17e-15 | 1.33e-13 | 97 |
GO:000705114 | Esophagus | ESCC | spindle organization | 134/8552 | 184/18723 | 5.70e-14 | 2.87e-12 | 134 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:00482853 | Esophagus | ESCC | organelle fission | 301/8552 | 488/18723 | 4.64e-13 | 2.12e-11 | 301 |
GO:00002802 | Esophagus | ESCC | nuclear division | 270/8552 | 439/18723 | 1.17e-11 | 4.24e-10 | 270 |
GO:00516075 | Esophagus | ESCC | defense response to virus | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:01405465 | Esophagus | ESCC | defense response to symbiont | 171/8552 | 265/18723 | 3.91e-10 | 1.05e-08 | 171 |
GO:0030522110 | Esophagus | ESCC | intracellular receptor signaling pathway | 170/8552 | 265/18723 | 8.58e-10 | 2.09e-08 | 170 |
GO:00512256 | Esophagus | ESCC | spindle assembly | 85/8552 | 117/18723 | 2.72e-09 | 5.98e-08 | 85 |
GO:003434013 | Esophagus | ESCC | response to type I interferon | 48/8552 | 58/18723 | 6.18e-09 | 1.26e-07 | 48 |
GO:009030715 | Esophagus | ESCC | mitotic spindle assembly | 52/8552 | 65/18723 | 1.41e-08 | 2.77e-07 | 52 |
GO:00603375 | Esophagus | ESCC | type I interferon signaling pathway | 41/8552 | 50/18723 | 1.35e-07 | 2.17e-06 | 41 |
GO:00713575 | Esophagus | ESCC | cellular response to type I interferon | 42/8552 | 52/18723 | 2.15e-07 | 3.30e-06 | 42 |
GO:00028318 | Esophagus | ESCC | regulation of response to biotic stimulus | 191/8552 | 327/18723 | 2.12e-06 | 2.45e-05 | 191 |
GO:00607595 | Esophagus | ESCC | regulation of response to cytokine stimulus | 103/8552 | 162/18723 | 3.14e-06 | 3.53e-05 | 103 |
GO:003406315 | Esophagus | ESCC | stress granule assembly | 23/8552 | 26/18723 | 6.82e-06 | 6.90e-05 | 23 |
GO:00019595 | Esophagus | ESCC | regulation of cytokine-mediated signaling pathway | 95/8552 | 150/18723 | 9.48e-06 | 9.04e-05 | 95 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LSM14A | SNV | Missense_Mutation | c.1180N>A | p.Glu394Lys | p.E394K | Q8ND56 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LSM14A | deletion | In_Frame_Del | novel | c.104_118delCCGTAGCCCTTGCCA | p.Thr35_Ala39del | p.T35_A39del | Q8ND56 | protein_coding | TCGA-S3-AA10-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cytoxan | CR | ||
LSM14A | SNV | Missense_Mutation | novel | c.1345N>C | p.Glu449Gln | p.E449Q | Q8ND56 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.584) | TCGA-C5-A3HL-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-AA-3864-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LSM14A | SNV | Missense_Mutation | novel | c.1312C>T | p.Arg438Cys | p.R438C | Q8ND56 | protein_coding | tolerated_low_confidence(0.09) | possibly_damaging(0.648) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LSM14A | SNV | Missense_Mutation | c.580N>G | p.Thr194Ala | p.T194A | Q8ND56 | protein_coding | tolerated(0.1) | benign(0.083) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD | |
LSM14A | SNV | Missense_Mutation | c.814C>T | p.Arg272Cys | p.R272C | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.051) | TCGA-D5-6930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LSM14A | SNV | Missense_Mutation | rs377088182 | c.158N>A | p.Arg53His | p.R53H | Q8ND56 | protein_coding | tolerated(0.05) | possibly_damaging(0.76) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
LSM14A | SNV | Missense_Mutation | c.526C>A | p.Gln176Lys | p.Q176K | Q8ND56 | protein_coding | tolerated(0.06) | benign(0.392) | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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