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Gene: LDLRAP1 |
Gene summary for LDLRAP1 |
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Gene information | Species | Human | Gene symbol | LDLRAP1 | Gene ID | 26119 |
Gene name | low density lipoprotein receptor adaptor protein 1 | |
Gene Alias | ARH | |
Cytomap | 1p36.11 | |
Gene Type | protein-coding | GO ID | GO:0006066 | UniProtAcc | B3KR97 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26119 | LDLRAP1 | HTA11_3410_2000001011 | Human | Colorectum | AD | 9.37e-05 | 1.29e-01 | 0.0155 |
26119 | LDLRAP1 | HTA11_2487_2000001011 | Human | Colorectum | SER | 1.44e-02 | 3.53e-01 | -0.1808 |
26119 | LDLRAP1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.97e-07 | 5.85e-01 | -0.0811 |
26119 | LDLRAP1 | HTA11_347_2000001011 | Human | Colorectum | AD | 6.63e-13 | 3.44e-01 | -0.1954 |
26119 | LDLRAP1 | HTA11_83_2000001011 | Human | Colorectum | SER | 1.54e-05 | 4.22e-01 | -0.1526 |
26119 | LDLRAP1 | HTA11_696_2000001011 | Human | Colorectum | AD | 8.03e-09 | 4.47e-01 | -0.1464 |
26119 | LDLRAP1 | HTA11_866_2000001011 | Human | Colorectum | AD | 3.92e-02 | 1.77e-01 | -0.1001 |
26119 | LDLRAP1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.92e-09 | 4.89e-01 | -0.059 |
26119 | LDLRAP1 | HTA11_546_2000001011 | Human | Colorectum | AD | 3.77e-04 | 3.49e-01 | -0.0842 |
26119 | LDLRAP1 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.08e-04 | 1.41e-01 | 0.096 |
26119 | LDLRAP1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 4.22e-02 | 3.90e-01 | 0.0131 |
26119 | LDLRAP1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.23e-06 | 3.55e-01 | 0.0674 |
26119 | LDLRAP1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 7.81e-03 | 2.71e-01 | 0.3859 |
26119 | LDLRAP1 | LZE5T | Human | Esophagus | ESCC | 7.53e-04 | 3.89e-01 | 0.0514 |
26119 | LDLRAP1 | LZE7T | Human | Esophagus | ESCC | 1.40e-02 | 2.05e-01 | 0.0667 |
26119 | LDLRAP1 | LZE8T | Human | Esophagus | ESCC | 2.51e-04 | 1.41e-01 | 0.067 |
26119 | LDLRAP1 | LZE20T | Human | Esophagus | ESCC | 1.63e-07 | 1.60e-01 | 0.0662 |
26119 | LDLRAP1 | LZE22T | Human | Esophagus | ESCC | 4.58e-02 | 1.66e-01 | 0.068 |
26119 | LDLRAP1 | LZE24T | Human | Esophagus | ESCC | 7.88e-27 | 5.66e-01 | 0.0596 |
26119 | LDLRAP1 | P1T-E | Human | Esophagus | ESCC | 2.18e-05 | 2.69e-01 | 0.0875 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00323671 | Esophagus | ESCC | intracellular cholesterol transport | 20/8552 | 29/18723 | 9.66e-03 | 3.34e-02 | 20 |
GO:00192168 | Esophagus | ESCC | regulation of lipid metabolic process | 172/8552 | 331/18723 | 1.20e-02 | 4.02e-02 | 172 |
GO:003238615 | Oral cavity | OSCC | regulation of intracellular transport | 218/7305 | 337/18723 | 6.91e-22 | 1.41e-19 | 218 |
GO:003238818 | Oral cavity | OSCC | positive regulation of intracellular transport | 134/7305 | 202/18723 | 2.82e-15 | 1.88e-13 | 134 |
GO:005109820 | Oral cavity | OSCC | regulation of binding | 212/7305 | 363/18723 | 3.88e-14 | 2.15e-12 | 212 |
GO:007265918 | Oral cavity | OSCC | protein localization to plasma membrane | 169/7305 | 284/18723 | 1.69e-12 | 7.21e-11 | 169 |
GO:199077816 | Oral cavity | OSCC | protein localization to cell periphery | 190/7305 | 333/18723 | 1.46e-11 | 5.13e-10 | 190 |
GO:004339318 | Oral cavity | OSCC | regulation of protein binding | 121/7305 | 196/18723 | 8.92e-11 | 2.73e-09 | 121 |
GO:190547516 | Oral cavity | OSCC | regulation of protein localization to membrane | 105/7305 | 175/18723 | 1.42e-08 | 2.85e-07 | 105 |
GO:003010016 | Oral cavity | OSCC | regulation of endocytosis | 121/7305 | 211/18723 | 4.74e-08 | 8.80e-07 | 121 |
GO:190437516 | Oral cavity | OSCC | regulation of protein localization to cell periphery | 78/7305 | 125/18723 | 9.80e-08 | 1.68e-06 | 78 |
GO:190307617 | Oral cavity | OSCC | regulation of protein localization to plasma membrane | 67/7305 | 104/18723 | 1.34e-07 | 2.24e-06 | 67 |
GO:00060667 | Oral cavity | OSCC | alcohol metabolic process | 179/7305 | 353/18723 | 4.54e-06 | 5.21e-05 | 179 |
GO:004580710 | Oral cavity | OSCC | positive regulation of endocytosis | 59/7305 | 100/18723 | 3.99e-05 | 3.48e-04 | 59 |
GO:000689810 | Oral cavity | OSCC | receptor-mediated endocytosis | 125/7305 | 244/18723 | 6.56e-05 | 5.32e-04 | 125 |
GO:004311210 | Oral cavity | OSCC | receptor metabolic process | 88/7305 | 166/18723 | 1.68e-04 | 1.15e-03 | 88 |
GO:19026523 | Oral cavity | OSCC | secondary alcohol metabolic process | 79/7305 | 147/18723 | 1.98e-04 | 1.33e-03 | 79 |
GO:00082033 | Oral cavity | OSCC | cholesterol metabolic process | 72/7305 | 137/18723 | 8.63e-04 | 4.55e-03 | 72 |
GO:00429823 | Oral cavity | OSCC | amyloid precursor protein metabolic process | 52/7305 | 95/18723 | 1.33e-03 | 6.62e-03 | 52 |
GO:00161253 | Oral cavity | OSCC | sterol metabolic process | 77/7305 | 152/18723 | 2.26e-03 | 1.00e-02 | 77 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04144 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041441 | Colorectum | AD | Endocytosis | 111/2092 | 251/8465 | 5.95e-12 | 1.42e-10 | 9.08e-11 | 111 |
hsa041442 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041443 | Colorectum | SER | Endocytosis | 81/1580 | 251/8465 | 1.14e-07 | 2.36e-06 | 1.71e-06 | 81 |
hsa041444 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa041445 | Colorectum | MSS | Endocytosis | 102/1875 | 251/8465 | 1.85e-11 | 4.43e-10 | 2.71e-10 | 102 |
hsa04144210 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414437 | Esophagus | ESCC | Endocytosis | 186/4205 | 251/8465 | 9.74e-16 | 4.66e-14 | 2.39e-14 | 186 |
hsa0414427 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa04144112 | Oral cavity | OSCC | Endocytosis | 174/3704 | 251/8465 | 9.42e-17 | 4.51e-15 | 2.29e-15 | 174 |
hsa0414428 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
hsa0414436 | Oral cavity | LP | Endocytosis | 121/2418 | 251/8465 | 1.89e-11 | 3.70e-10 | 2.38e-10 | 121 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LDLRAP1 | SNV | Missense_Mutation | rs867337699 | c.200C>T | p.Ser67Leu | p.S67L | Q5SW96 | protein_coding | deleterious(0) | possibly_damaging(0.642) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LDLRAP1 | SNV | Missense_Mutation | novel | c.757G>A | p.Asp253Asn | p.D253N | Q5SW96 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LDLRAP1 | SNV | Missense_Mutation | novel | c.101N>G | p.Asn34Ser | p.N34S | Q5SW96 | protein_coding | tolerated(0.06) | possibly_damaging(0.527) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LDLRAP1 | SNV | Missense_Mutation | rs529005321 | c.397G>A | p.Ala133Thr | p.A133T | Q5SW96 | protein_coding | deleterious(0.05) | benign(0.299) | TCGA-CK-5913-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LDLRAP1 | SNV | Missense_Mutation | c.775N>C | p.Phe259Leu | p.F259L | Q5SW96 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LDLRAP1 | SNV | Missense_Mutation | rs752849346 | c.167N>T | p.Thr56Met | p.T56M | Q5SW96 | protein_coding | deleterious(0.04) | probably_damaging(0.999) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LDLRAP1 | SNV | Missense_Mutation | novel | c.513T>G | p.Phe171Leu | p.F171L | Q5SW96 | protein_coding | tolerated(0.99) | benign(0.001) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LDLRAP1 | SNV | Missense_Mutation | novel | c.438C>A | p.Phe146Leu | p.F146L | Q5SW96 | protein_coding | deleterious(0) | possibly_damaging(0.895) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LDLRAP1 | SNV | Missense_Mutation | novel | c.878N>G | p.Asp293Gly | p.D293G | Q5SW96 | protein_coding | deleterious_low_confidence(0.03) | benign(0.171) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LDLRAP1 | SNV | Missense_Mutation | novel | c.574N>A | p.Val192Ile | p.V192I | Q5SW96 | protein_coding | tolerated(0.22) | benign(0) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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