![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KIF2A |
Gene summary for KIF2A |
![]() |
Gene information | Species | Human | Gene symbol | KIF2A | Gene ID | 3796 |
Gene name | kinesin family member 2A | |
Gene Alias | CDCBM3 | |
Cytomap | 5q12.1 | |
Gene Type | protein-coding | GO ID | GO:0000226 | UniProtAcc | O00139 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3796 | KIF2A | LZE4T | Human | Esophagus | ESCC | 3.16e-09 | 3.37e-01 | 0.0811 |
3796 | KIF2A | LZE7T | Human | Esophagus | ESCC | 3.57e-07 | 3.88e-01 | 0.0667 |
3796 | KIF2A | LZE8T | Human | Esophagus | ESCC | 3.60e-02 | 1.08e-01 | 0.067 |
3796 | KIF2A | LZE20T | Human | Esophagus | ESCC | 1.77e-03 | 1.37e-01 | 0.0662 |
3796 | KIF2A | LZE24T | Human | Esophagus | ESCC | 1.21e-11 | 3.92e-01 | 0.0596 |
3796 | KIF2A | P1T-E | Human | Esophagus | ESCC | 1.23e-12 | 6.07e-01 | 0.0875 |
3796 | KIF2A | P2T-E | Human | Esophagus | ESCC | 8.40e-86 | 1.45e+00 | 0.1177 |
3796 | KIF2A | P4T-E | Human | Esophagus | ESCC | 1.37e-20 | 4.87e-01 | 0.1323 |
3796 | KIF2A | P5T-E | Human | Esophagus | ESCC | 8.29e-13 | 2.73e-01 | 0.1327 |
3796 | KIF2A | P8T-E | Human | Esophagus | ESCC | 4.05e-29 | 3.93e-01 | 0.0889 |
3796 | KIF2A | P9T-E | Human | Esophagus | ESCC | 8.07e-14 | 2.53e-01 | 0.1131 |
3796 | KIF2A | P10T-E | Human | Esophagus | ESCC | 3.58e-25 | 4.37e-01 | 0.116 |
3796 | KIF2A | P11T-E | Human | Esophagus | ESCC | 1.96e-14 | 6.03e-01 | 0.1426 |
3796 | KIF2A | P12T-E | Human | Esophagus | ESCC | 1.32e-32 | 6.58e-01 | 0.1122 |
3796 | KIF2A | P15T-E | Human | Esophagus | ESCC | 4.54e-23 | 5.63e-01 | 0.1149 |
3796 | KIF2A | P16T-E | Human | Esophagus | ESCC | 3.94e-48 | 7.47e-01 | 0.1153 |
3796 | KIF2A | P17T-E | Human | Esophagus | ESCC | 1.01e-05 | 4.44e-01 | 0.1278 |
3796 | KIF2A | P19T-E | Human | Esophagus | ESCC | 6.26e-08 | 4.69e-01 | 0.1662 |
3796 | KIF2A | P20T-E | Human | Esophagus | ESCC | 3.20e-36 | 7.95e-01 | 0.1124 |
3796 | KIF2A | P21T-E | Human | Esophagus | ESCC | 1.28e-35 | 6.49e-01 | 0.1617 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004828512 | Thyroid | ATC | organelle fission | 229/6293 | 488/18723 | 4.79e-10 | 1.29e-08 | 229 |
GO:000028011 | Thyroid | ATC | nuclear division | 207/6293 | 439/18723 | 1.98e-09 | 4.80e-08 | 207 |
GO:005122521 | Thyroid | ATC | spindle assembly | 66/6293 | 117/18723 | 3.28e-07 | 4.88e-06 | 66 |
GO:009030721 | Thyroid | ATC | mitotic spindle assembly | 41/6293 | 65/18723 | 1.10e-06 | 1.43e-05 | 41 |
GO:004362412 | Thyroid | ATC | cellular protein complex disassembly | 69/6293 | 136/18723 | 2.66e-05 | 2.28e-04 | 69 |
GO:005126111 | Thyroid | ATC | protein depolymerization | 59/6293 | 114/18723 | 4.74e-05 | 3.80e-04 | 59 |
GO:003110912 | Thyroid | ATC | microtubule polymerization or depolymerization | 61/6293 | 122/18723 | 1.30e-04 | 9.15e-04 | 61 |
Page: 1 2 3 4 5 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF2A | SNV | Missense_Mutation | rs767638932 | c.182N>T | p.Ser61Leu | p.S61L | O00139 | protein_coding | tolerated(0.11) | benign(0.007) | TCGA-A1-A0SF-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD |
KIF2A | SNV | Missense_Mutation | c.208N>A | p.Glu70Lys | p.E70K | O00139 | protein_coding | tolerated(0.36) | benign(0.155) | TCGA-A8-A09N-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KIF2A | SNV | Missense_Mutation | c.2045N>T | p.Ala682Val | p.A682V | O00139 | protein_coding | tolerated(0.48) | benign(0.001) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIF2A | SNV | Missense_Mutation | c.1675N>C | p.Asp559His | p.D559H | O00139 | protein_coding | tolerated(0.08) | probably_damaging(0.996) | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | |
KIF2A | SNV | Missense_Mutation | c.674G>A | p.Cys225Tyr | p.C225Y | O00139 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIF2A | SNV | Missense_Mutation | c.72N>G | p.Ile24Met | p.I24M | O00139 | protein_coding | deleterious(0) | possibly_damaging(0.885) | TCGA-D8-A27M-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | methotrexate+5 | SD | |
KIF2A | insertion | In_Frame_Ins | novel | c.1307_1308insGTCCTT | p.His436delinsGlnSerPhe | p.H436delinsQSF | O00139 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIF2A | insertion | Frame_Shift_Ins | novel | c.1309_1310insAAACTTTTCAACTT | p.Ala437GlufsTer55 | p.A437Efs*55 | O00139 | protein_coding | TCGA-AN-A0FS-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KIF2A | SNV | Missense_Mutation | c.177N>G | p.Ile59Met | p.I59M | O00139 | protein_coding | deleterious(0) | possibly_damaging(0.805) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
KIF2A | SNV | Missense_Mutation | c.1741N>G | p.Phe581Val | p.F581V | O00139 | protein_coding | tolerated(0.52) | probably_damaging(0.943) | TCGA-Q1-A73O-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
Page: 1 2 3 4 5 6 7 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |