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Gene: JADE1 |
Gene summary for JADE1 |
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Gene information | Species | Human | Gene symbol | JADE1 | Gene ID | 79960 |
Gene name | jade family PHD finger 1 | |
Gene Alias | PHF17 | |
Cytomap | 4q28.2 | |
Gene Type | protein-coding | GO ID | GO:0000082 | UniProtAcc | Q6IE81 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79960 | JADE1 | Adj_PTCwithHT_6 | Human | Thyroid | HT | 6.67e-08 | -4.51e-01 | 0.02 |
79960 | JADE1 | Adj_PTCwithHT_8 | Human | Thyroid | HT | 3.86e-03 | -4.09e-01 | 0.0267 |
79960 | JADE1 | PTCwithHT_6 | Human | Thyroid | HT | 1.99e-03 | -4.52e-01 | 0.02 |
79960 | JADE1 | PTCwithHT_8 | Human | Thyroid | HT | 2.29e-06 | -4.46e-01 | 0.0351 |
79960 | JADE1 | PTCwithoutHT_2 | Human | Thyroid | PTC | 4.82e-05 | -4.03e-01 | 0.0419 |
79960 | JADE1 | male-WTA | Human | Thyroid | PTC | 3.85e-47 | 9.69e-02 | 0.1037 |
79960 | JADE1 | PTC01 | Human | Thyroid | PTC | 2.48e-10 | 5.94e-01 | 0.1899 |
79960 | JADE1 | PTC03 | Human | Thyroid | PTC | 1.13e-04 | -1.90e-01 | 0.1784 |
79960 | JADE1 | PTC04 | Human | Thyroid | PTC | 1.02e-04 | 4.05e-01 | 0.1927 |
79960 | JADE1 | PTC05 | Human | Thyroid | PTC | 6.90e-10 | 6.56e-01 | 0.2065 |
79960 | JADE1 | PTC06 | Human | Thyroid | PTC | 1.24e-17 | 6.11e-01 | 0.2057 |
79960 | JADE1 | PTC07 | Human | Thyroid | PTC | 2.53e-33 | 6.32e-01 | 0.2044 |
79960 | JADE1 | ATC08 | Human | Thyroid | ATC | 1.73e-03 | -4.07e-01 | 0.0541 |
79960 | JADE1 | ATC09 | Human | Thyroid | ATC | 3.23e-06 | -3.56e-01 | 0.2871 |
79960 | JADE1 | ATC11 | Human | Thyroid | ATC | 1.73e-04 | -1.81e-01 | 0.3386 |
79960 | JADE1 | ATC12 | Human | Thyroid | ATC | 1.24e-10 | -3.54e-01 | 0.34 |
79960 | JADE1 | ATC13 | Human | Thyroid | ATC | 1.69e-14 | -2.49e-01 | 0.34 |
79960 | JADE1 | ATC1 | Human | Thyroid | ATC | 5.64e-05 | -3.52e-01 | 0.2878 |
79960 | JADE1 | ATC2 | Human | Thyroid | ATC | 7.33e-07 | 2.99e-01 | 0.34 |
79960 | JADE1 | ATC3 | Human | Thyroid | ATC | 3.92e-06 | -1.53e-01 | 0.338 |
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Tissue | Expression Dynamics | Abbreviation |
Thyroid | ![]() | ATC: Anaplastic thyroid cancer |
HT: Hashimoto's thyroiditis | ||
PTC: Papillary thyroid cancer |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004396611 | Thyroid | ATC | histone H3 acetylation | 34/6293 | 61/18723 | 3.10e-04 | 1.94e-03 | 34 |
GO:200013413 | Thyroid | ATC | negative regulation of G1/S transition of mitotic cell cycle | 40/6293 | 84/18723 | 5.33e-03 | 2.17e-02 | 40 |
GO:004398111 | Thyroid | ATC | histone H4-K5 acetylation | 10/6293 | 15/18723 | 9.05e-03 | 3.39e-02 | 10 |
GO:004398211 | Thyroid | ATC | histone H4-K8 acetylation | 10/6293 | 15/18723 | 9.05e-03 | 3.39e-02 | 10 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
JADE1 | SNV | Missense_Mutation | c.1727N>G | p.Ser576Cys | p.S576C | Q6IE81 | protein_coding | deleterious(0.01) | benign(0) | TCGA-A1-A0SH-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | tc | SD | |
JADE1 | SNV | Missense_Mutation | novel | c.128A>C | p.Lys43Thr | p.K43T | Q6IE81 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
JADE1 | SNV | Missense_Mutation | novel | c.1988G>C | p.Arg663Pro | p.R663P | Q6IE81 | protein_coding | tolerated(0.22) | benign(0.006) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
JADE1 | SNV | Missense_Mutation | novel | c.86C>G | p.Ser29Cys | p.S29C | Q6IE81 | protein_coding | tolerated(0.06) | probably_damaging(0.979) | TCGA-AR-A2LE-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | PD |
JADE1 | SNV | Missense_Mutation | c.307G>A | p.Glu103Lys | p.E103K | Q6IE81 | protein_coding | deleterious(0.01) | possibly_damaging(0.688) | TCGA-C8-A12P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
JADE1 | insertion | Nonsense_Mutation | novel | c.100_101insACCCATGTTGATGGGGTACATGGAGAGGAGGAACCCACAGAGT | p.Ser34AsnfsTer4 | p.S34Nfs*4 | Q6IE81 | protein_coding | TCGA-A8-A06O-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | letrozole | SD | ||
JADE1 | insertion | Frame_Shift_Ins | novel | c.1418_1419insGAATAGACCATTAT | p.Glu474AsnfsTer5 | p.E474Nfs*5 | Q6IE81 | protein_coding | TCGA-A8-A096-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
JADE1 | insertion | Nonsense_Mutation | novel | c.1235_1236insCATCTCTATAAAAAAAATTCCAAGCCTTACCTCTTTTAAAACATGACA | p.Arg412_Val413insIleSerIleLysLysIleProSerLeuThrSerPheLysThrTerGln | p.R412_V413insISIKKIPSLTSFKT*Q | Q6IE81 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
JADE1 | insertion | Frame_Shift_Ins | novel | c.281_282insGTGG | p.Gln95TrpfsTer10 | p.Q95Wfs*10 | Q6IE81 | protein_coding | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
JADE1 | insertion | Nonsense_Mutation | novel | c.283_284insCTTGATACAGCATCCCTGCACAGAATGAGCACATT | p.Gln95ProfsTer2 | p.Q95Pfs*2 | Q6IE81 | protein_coding | TCGA-BH-A0BR-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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