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Gene: INPP5K |
Gene summary for INPP5K |
Gene summary. |
Gene information | Species | Human | Gene symbol | INPP5K | Gene ID | 51763 |
Gene name | inositol polyphosphate-5-phosphatase K | |
Gene Alias | MDCCAID | |
Cytomap | 17p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | Q9BT40 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
51763 | INPP5K | LZE4T | Human | Esophagus | ESCC | 4.90e-08 | 3.18e-01 | 0.0811 |
51763 | INPP5K | LZE7T | Human | Esophagus | ESCC | 2.33e-04 | 1.95e-01 | 0.0667 |
51763 | INPP5K | LZE8T | Human | Esophagus | ESCC | 1.09e-07 | 1.18e-01 | 0.067 |
51763 | INPP5K | LZE21D1 | Human | Esophagus | HGIN | 2.29e-02 | 2.25e-01 | 0.0632 |
51763 | INPP5K | LZE22T | Human | Esophagus | ESCC | 1.29e-03 | 2.91e-01 | 0.068 |
51763 | INPP5K | LZE24T | Human | Esophagus | ESCC | 2.28e-22 | 6.12e-01 | 0.0596 |
51763 | INPP5K | LZE21T | Human | Esophagus | ESCC | 2.00e-06 | 2.50e-01 | 0.0655 |
51763 | INPP5K | P1T-E | Human | Esophagus | ESCC | 9.00e-13 | 6.12e-01 | 0.0875 |
51763 | INPP5K | P2T-E | Human | Esophagus | ESCC | 1.12e-22 | 3.52e-01 | 0.1177 |
51763 | INPP5K | P4T-E | Human | Esophagus | ESCC | 4.96e-13 | 3.60e-01 | 0.1323 |
51763 | INPP5K | P5T-E | Human | Esophagus | ESCC | 1.04e-05 | 9.09e-02 | 0.1327 |
51763 | INPP5K | P8T-E | Human | Esophagus | ESCC | 7.15e-18 | 3.48e-01 | 0.0889 |
51763 | INPP5K | P9T-E | Human | Esophagus | ESCC | 1.54e-13 | 3.86e-01 | 0.1131 |
51763 | INPP5K | P10T-E | Human | Esophagus | ESCC | 2.09e-32 | 4.56e-01 | 0.116 |
51763 | INPP5K | P11T-E | Human | Esophagus | ESCC | 8.79e-14 | 5.25e-01 | 0.1426 |
51763 | INPP5K | P12T-E | Human | Esophagus | ESCC | 1.57e-29 | 4.78e-01 | 0.1122 |
51763 | INPP5K | P15T-E | Human | Esophagus | ESCC | 1.20e-09 | 1.81e-01 | 0.1149 |
51763 | INPP5K | P16T-E | Human | Esophagus | ESCC | 4.00e-25 | 4.72e-01 | 0.1153 |
51763 | INPP5K | P17T-E | Human | Esophagus | ESCC | 9.80e-12 | 4.11e-01 | 0.1278 |
51763 | INPP5K | P19T-E | Human | Esophagus | ESCC | 1.69e-13 | 6.96e-01 | 0.1662 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004852516 | Esophagus | ESCC | negative regulation of viral process | 66/8552 | 92/18723 | 3.49e-07 | 4.88e-06 | 66 |
GO:0032956111 | Esophagus | ESCC | regulation of actin cytoskeleton organization | 210/8552 | 358/18723 | 4.40e-07 | 6.00e-06 | 210 |
GO:004507114 | Esophagus | ESCC | negative regulation of viral genome replication | 44/8552 | 56/18723 | 4.84e-07 | 6.50e-06 | 44 |
GO:00450175 | Esophagus | ESCC | glycerolipid biosynthetic process | 154/8552 | 252/18723 | 5.20e-07 | 6.96e-06 | 154 |
GO:011005327 | Esophagus | ESCC | regulation of actin filament organization | 166/8552 | 278/18723 | 1.54e-06 | 1.85e-05 | 166 |
GO:190165319 | Esophagus | ESCC | cellular response to peptide | 208/8552 | 359/18723 | 1.68e-06 | 2.01e-05 | 208 |
GO:00182099 | Esophagus | ESCC | peptidyl-serine modification | 196/8552 | 338/18723 | 3.07e-06 | 3.47e-05 | 196 |
GO:001810515 | Esophagus | ESCC | peptidyl-serine phosphorylation | 184/8552 | 315/18723 | 3.22e-06 | 3.61e-05 | 184 |
GO:005101727 | Esophagus | ESCC | actin filament bundle assembly | 100/8552 | 157/18723 | 3.87e-06 | 4.17e-05 | 100 |
GO:0043434111 | Esophagus | ESCC | response to peptide hormone | 234/8552 | 414/18723 | 4.93e-06 | 5.21e-05 | 234 |
GO:007084919 | Esophagus | ESCC | response to epidermal growth factor | 38/8552 | 49/18723 | 5.24e-06 | 5.49e-05 | 38 |
GO:00066446 | Esophagus | ESCC | phospholipid metabolic process | 218/8552 | 383/18723 | 5.37e-06 | 5.59e-05 | 218 |
GO:190353315 | Esophagus | ESCC | regulation of protein targeting | 57/8552 | 81/18723 | 5.83e-06 | 6.03e-05 | 57 |
GO:003286918 | Esophagus | ESCC | cellular response to insulin stimulus | 124/8552 | 203/18723 | 6.63e-06 | 6.75e-05 | 124 |
GO:003286818 | Esophagus | ESCC | response to insulin | 156/8552 | 264/18723 | 7.21e-06 | 7.20e-05 | 156 |
GO:00060668 | Esophagus | ESCC | alcohol metabolic process | 202/8552 | 353/18723 | 7.32e-06 | 7.26e-05 | 202 |
GO:006157227 | Esophagus | ESCC | actin filament bundle organization | 101/8552 | 161/18723 | 9.22e-06 | 8.82e-05 | 101 |
GO:007136419 | Esophagus | ESCC | cellular response to epidermal growth factor stimulus | 35/8552 | 45/18723 | 1.11e-05 | 1.04e-04 | 35 |
GO:003461220 | Esophagus | ESCC | response to tumor necrosis factor | 149/8552 | 253/18723 | 1.47e-05 | 1.33e-04 | 149 |
GO:00060069 | Esophagus | ESCC | glucose metabolic process | 119/8552 | 196/18723 | 1.51e-05 | 1.36e-04 | 119 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
INPP5K | deletion | Frame_Shift_Del | novel | c.415delN | p.Tyr139MetfsTer55 | p.Y139Mfs*55 | Q9BT40 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
INPP5K | SNV | Missense_Mutation | novel | c.258C>G | p.Ile86Met | p.I86M | Q9BT40 | protein_coding | deleterious(0.01) | possibly_damaging(0.756) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | rs138972043 | c.1259N>A | p.Arg420His | p.R420H | Q9BT40 | protein_coding | tolerated(0.65) | benign(0.001) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | c.809N>A | p.Arg270His | p.R270H | Q9BT40 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-A02R-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
INPP5K | SNV | Missense_Mutation | rs779661934 | c.212N>T | p.Ser71Leu | p.S71L | Q9BT40 | protein_coding | deleterious(0.02) | benign(0.028) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | c.809G>A | p.Arg270His | p.R270H | Q9BT40 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR | |
INPP5K | SNV | Missense_Mutation | c.112C>A | p.Leu38Met | p.L38M | Q9BT40 | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-AF-6672-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Ancillary | leucovorin | PD | |
INPP5K | SNV | Missense_Mutation | novel | c.239N>C | p.Leu80Pro | p.L80P | Q9BT40 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | rs756203232 | c.1258N>T | p.Arg420Cys | p.R420C | Q9BT40 | protein_coding | deleterious(0.01) | possibly_damaging(0.513) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
INPP5K | SNV | Missense_Mutation | novel | c.989N>C | p.Leu330Pro | p.L330P | Q9BT40 | protein_coding | tolerated(0.07) | benign(0.027) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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