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Gene: IFI27 |
Gene summary for IFI27 |
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Gene information | Species | Human | Gene symbol | IFI27 | Gene ID | 3429 |
Gene name | interferon alpha inducible protein 27 | |
Gene Alias | FAM14D | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | A8K0H0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3429 | IFI27 | GSM4909281 | Human | Breast | IDC | 3.10e-136 | 1.91e+00 | 0.21 |
3429 | IFI27 | GSM4909282 | Human | Breast | IDC | 7.31e-08 | 3.76e-01 | -0.0288 |
3429 | IFI27 | GSM4909285 | Human | Breast | IDC | 3.06e-05 | 3.84e-01 | 0.21 |
3429 | IFI27 | GSM4909287 | Human | Breast | IDC | 1.81e-51 | 1.30e+00 | 0.2057 |
3429 | IFI27 | GSM4909288 | Human | Breast | IDC | 4.22e-09 | 1.03e+00 | 0.0988 |
3429 | IFI27 | GSM4909290 | Human | Breast | IDC | 1.60e-66 | 1.55e+00 | 0.2096 |
3429 | IFI27 | GSM4909294 | Human | Breast | IDC | 1.65e-06 | 4.77e-01 | 0.2022 |
3429 | IFI27 | GSM4909297 | Human | Breast | IDC | 5.88e-03 | 4.21e-01 | 0.1517 |
3429 | IFI27 | GSM4909307 | Human | Breast | IDC | 9.24e-100 | 1.71e+00 | 0.1569 |
3429 | IFI27 | GSM4909308 | Human | Breast | IDC | 7.77e-108 | 1.76e+00 | 0.158 |
3429 | IFI27 | GSM4909309 | Human | Breast | IDC | 3.93e-44 | 1.27e+00 | 0.0483 |
3429 | IFI27 | GSM4909315 | Human | Breast | IDC | 1.60e-123 | 1.94e+00 | 0.21 |
3429 | IFI27 | GSM4909316 | Human | Breast | IDC | 6.23e-29 | 1.62e+00 | 0.21 |
3429 | IFI27 | GSM4909317 | Human | Breast | IDC | 7.85e-55 | 1.42e+00 | 0.1355 |
3429 | IFI27 | GSM4909318 | Human | Breast | IDC | 7.18e-38 | 1.99e+00 | 0.2031 |
3429 | IFI27 | GSM4909320 | Human | Breast | IDC | 5.69e-05 | 8.56e-01 | 0.1575 |
3429 | IFI27 | GSM4909321 | Human | Breast | IDC | 2.07e-160 | 2.15e+00 | 0.1559 |
3429 | IFI27 | M1 | Human | Breast | IDC | 4.51e-38 | 1.26e+00 | 0.1577 |
3429 | IFI27 | M2 | Human | Breast | IDC | 5.13e-07 | 9.94e-01 | 0.21 |
3429 | IFI27 | NCCBC5 | Human | Breast | DCIS | 3.41e-85 | 1.81e+00 | 0.2046 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0000209 | Colorectum | AD | protein polyubiquitination | 78/3918 | 236/18723 | 8.71e-06 | 2.06e-04 | 78 |
GO:0046822 | Colorectum | AD | regulation of nucleocytoplasmic transport | 41/3918 | 106/18723 | 2.17e-05 | 4.33e-04 | 41 |
GO:0051168 | Colorectum | AD | nuclear export | 53/3918 | 154/18723 | 6.89e-05 | 1.11e-03 | 53 |
GO:0070936 | Colorectum | AD | protein K48-linked ubiquitination | 27/3918 | 65/18723 | 1.31e-04 | 1.88e-03 | 27 |
GO:0097191 | Colorectum | AD | extrinsic apoptotic signaling pathway | 68/3918 | 219/18723 | 2.64e-04 | 3.27e-03 | 68 |
GO:0006611 | Colorectum | AD | protein export from nucleus | 23/3918 | 57/18723 | 6.62e-04 | 6.80e-03 | 23 |
GO:0046825 | Colorectum | AD | regulation of protein export from nucleus | 14/3918 | 30/18723 | 1.43e-03 | 1.22e-02 | 14 |
GO:0034340 | Colorectum | AD | response to type I interferon | 22/3918 | 58/18723 | 2.23e-03 | 1.75e-02 | 22 |
GO:0060337 | Colorectum | AD | type I interferon signaling pathway | 19/3918 | 50/18723 | 4.23e-03 | 2.91e-02 | 19 |
GO:0035821 | Colorectum | AD | modulation of process of other organism | 34/3918 | 106/18723 | 4.73e-03 | 3.22e-02 | 34 |
GO:0071357 | Colorectum | AD | cellular response to type I interferon | 19/3918 | 52/18723 | 6.92e-03 | 4.26e-02 | 19 |
GO:00160321 | Colorectum | SER | viral process | 118/2897 | 415/18723 | 8.36e-12 | 1.65e-09 | 118 |
GO:00104981 | Colorectum | SER | proteasomal protein catabolic process | 132/2897 | 490/18723 | 3.08e-11 | 5.55e-09 | 132 |
GO:00190581 | Colorectum | SER | viral life cycle | 87/2897 | 317/18723 | 2.82e-08 | 1.94e-06 | 87 |
GO:00331571 | Colorectum | SER | regulation of intracellular protein transport | 68/2897 | 229/18723 | 3.41e-08 | 2.30e-06 | 68 |
GO:00431611 | Colorectum | SER | proteasome-mediated ubiquitin-dependent protein catabolic process | 105/2897 | 412/18723 | 7.48e-08 | 4.70e-06 | 105 |
GO:00323861 | Colorectum | SER | regulation of intracellular transport | 89/2897 | 337/18723 | 1.34e-07 | 7.96e-06 | 89 |
GO:00069131 | Colorectum | SER | nucleocytoplasmic transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00511691 | Colorectum | SER | nuclear transport | 77/2897 | 301/18723 | 3.39e-06 | 1.32e-04 | 77 |
GO:00468221 | Colorectum | SER | regulation of nucleocytoplasmic transport | 34/2897 | 106/18723 | 1.46e-05 | 4.47e-04 | 34 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IFI27 | SNV | Missense_Mutation | novel | c.92N>T | p.Ala31Val | p.A31V | protein_coding | tolerated(0.35) | benign(0.006) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IFI27 | SNV | Missense_Mutation | rs771278257 | c.344C>T | p.Ala115Val | p.A115V | protein_coding | tolerated(0.1) | benign(0.005) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
IFI27 | SNV | Missense_Mutation | rs755125237 | c.251N>T | p.Ser84Leu | p.S84L | protein_coding | deleterious(0) | benign(0.062) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response | |
IFI27 | SNV | Missense_Mutation | rs534344668 | c.301G>A | p.Gly101Arg | p.G101R | protein_coding | tolerated(0.39) | benign(0.003) | TCGA-EY-A215-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
IFI27 | SNV | Missense_Mutation | novel | c.197N>C | p.Ile66Thr | p.I66T | protein_coding | deleterious(0.02) | benign(0.333) | TCGA-46-6025-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Chemotherapy | cisplatin | SD | |
IFI27 | SNV | Missense_Mutation | novel | c.296T>G | p.Leu99Arg | p.L99R | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-51-4079-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3429 | IFI27 | NUCLEAR HORMONE RECEPTOR | TNF-ALPHA | 15086558 | ||
3429 | IFI27 | NUCLEAR HORMONE RECEPTOR | RETINOIDS | 15086558 | ||
3429 | IFI27 | NUCLEAR HORMONE RECEPTOR | VITAMIN D | 15086558 | ||
3429 | IFI27 | NUCLEAR HORMONE RECEPTOR | TGFBETA1 | 15086558 |
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