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Gene: GLG1 |
Gene summary for GLG1 |
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Gene information | Species | Human | Gene symbol | GLG1 | Gene ID | 2734 |
Gene name | golgi glycoprotein 1 | |
Gene Alias | CFR-1 | |
Cytomap | 16q23.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | Q92896 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2734 | GLG1 | CA_HPV_3 | Human | Cervix | CC | 4.32e-05 | 1.01e-01 | 0.0414 |
2734 | GLG1 | N_HPV_2 | Human | Cervix | N_HPV | 1.50e-02 | 5.79e-02 | -0.0131 |
2734 | GLG1 | CCI_1 | Human | Cervix | CC | 4.94e-02 | 5.14e-01 | 0.528 |
2734 | GLG1 | CCI_2 | Human | Cervix | CC | 3.50e-09 | 1.20e+00 | 0.5249 |
2734 | GLG1 | CCI_3 | Human | Cervix | CC | 1.02e-07 | 8.70e-01 | 0.516 |
2734 | GLG1 | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.10e-09 | 6.63e-01 | -0.0811 |
2734 | GLG1 | HTA11_78_2000001011 | Human | Colorectum | AD | 1.41e-04 | 5.54e-01 | -0.1088 |
2734 | GLG1 | HTA11_347_2000001011 | Human | Colorectum | AD | 7.08e-24 | 7.62e-01 | -0.1954 |
2734 | GLG1 | HTA11_411_2000001011 | Human | Colorectum | SER | 4.53e-04 | 7.16e-01 | -0.2602 |
2734 | GLG1 | HTA11_696_2000001011 | Human | Colorectum | AD | 3.80e-03 | 4.08e-01 | -0.1464 |
2734 | GLG1 | HTA11_1391_2000001011 | Human | Colorectum | AD | 4.91e-06 | 6.09e-01 | -0.059 |
2734 | GLG1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 9.54e-03 | 4.29e-01 | 0.0588 |
2734 | GLG1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.68e-02 | 7.55e-01 | 0.3487 |
2734 | GLG1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.11e-13 | 8.34e-01 | 0.281 |
2734 | GLG1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.02e-02 | 5.66e-01 | 0.3859 |
2734 | GLG1 | A015-C-203 | Human | Colorectum | FAP | 7.71e-28 | -1.82e-01 | -0.1294 |
2734 | GLG1 | A015-C-204 | Human | Colorectum | FAP | 9.51e-04 | -1.83e-01 | -0.0228 |
2734 | GLG1 | A014-C-040 | Human | Colorectum | FAP | 1.49e-03 | -3.00e-01 | -0.1184 |
2734 | GLG1 | A002-C-201 | Human | Colorectum | FAP | 7.48e-10 | -1.34e-01 | 0.0324 |
2734 | GLG1 | A002-C-203 | Human | Colorectum | FAP | 3.97e-02 | 1.61e-02 | 0.2786 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00170152 | Liver | Cirrhotic | regulation of transforming growth factor beta receptor signaling pathway | 46/4634 | 128/18723 | 3.04e-03 | 1.72e-02 | 46 |
GO:0070613 | Liver | Cirrhotic | regulation of protein processing | 26/4634 | 65/18723 | 4.73e-03 | 2.48e-02 | 26 |
GO:0010955 | Liver | Cirrhotic | negative regulation of protein processing | 14/4634 | 29/18723 | 5.09e-03 | 2.62e-02 | 14 |
GO:1903318 | Liver | Cirrhotic | negative regulation of protein maturation | 14/4634 | 29/18723 | 5.09e-03 | 2.62e-02 | 14 |
GO:005160412 | Liver | HCC | protein maturation | 171/7958 | 294/18723 | 3.80e-08 | 8.30e-07 | 171 |
GO:007155921 | Liver | HCC | response to transforming growth factor beta | 141/7958 | 256/18723 | 3.08e-05 | 3.16e-04 | 141 |
GO:004586122 | Liver | HCC | negative regulation of proteolysis | 186/7958 | 351/18723 | 4.19e-05 | 4.11e-04 | 186 |
GO:007156021 | Liver | HCC | cellular response to transforming growth factor beta stimulus | 137/7958 | 250/18723 | 5.47e-05 | 5.14e-04 | 137 |
GO:001648511 | Liver | HCC | protein processing | 121/7958 | 225/18723 | 4.01e-04 | 2.71e-03 | 121 |
GO:000717921 | Liver | HCC | transforming growth factor beta receptor signaling pathway | 106/7958 | 198/18723 | 1.09e-03 | 6.23e-03 | 106 |
GO:19038442 | Liver | HCC | regulation of cellular response to transforming growth factor beta stimulus | 72/7958 | 131/18723 | 2.65e-03 | 1.27e-02 | 72 |
GO:001701511 | Liver | HCC | regulation of transforming growth factor beta receptor signaling pathway | 70/7958 | 128/18723 | 3.56e-03 | 1.59e-02 | 70 |
GO:19033171 | Liver | HCC | regulation of protein maturation | 39/7958 | 67/18723 | 6.84e-03 | 2.74e-02 | 39 |
GO:00706131 | Liver | HCC | regulation of protein processing | 37/7958 | 65/18723 | 1.33e-02 | 4.77e-02 | 37 |
GO:00715594 | Lung | IAC | response to transforming growth factor beta | 60/2061 | 256/18723 | 9.50e-09 | 1.25e-06 | 60 |
GO:00715604 | Lung | IAC | cellular response to transforming growth factor beta stimulus | 57/2061 | 250/18723 | 6.17e-08 | 6.54e-06 | 57 |
GO:00071794 | Lung | IAC | transforming growth factor beta receptor signaling pathway | 45/2061 | 198/18723 | 1.60e-06 | 7.93e-05 | 45 |
GO:00071785 | Lung | IAC | transmembrane receptor protein serine/threonine kinase signaling pathway | 60/2061 | 355/18723 | 4.82e-04 | 7.03e-03 | 60 |
GO:19038444 | Lung | IAC | regulation of cellular response to transforming growth factor beta stimulus | 27/2061 | 131/18723 | 9.41e-04 | 1.14e-02 | 27 |
GO:00458618 | Lung | IAC | negative regulation of proteolysis | 58/2061 | 351/18723 | 1.04e-03 | 1.24e-02 | 58 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa045147 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0451412 | Cervix | CC | Cell adhesion molecules | 36/1267 | 157/8465 | 4.94e-03 | 1.67e-02 | 9.86e-03 | 36 |
hsa0451441 | Cervix | N_HPV | Cell adhesion molecules | 18/349 | 157/8465 | 7.71e-05 | 8.06e-04 | 6.30e-04 | 18 |
hsa0451451 | Cervix | N_HPV | Cell adhesion molecules | 18/349 | 157/8465 | 7.71e-05 | 8.06e-04 | 6.30e-04 | 18 |
hsa045146 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
hsa0451411 | Lung | IAC | Cell adhesion molecules | 30/1053 | 157/8465 | 1.03e-02 | 3.83e-02 | 2.54e-02 | 30 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
SELE | GLG1 | SELE_GLG1 | SELE | Breast | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Breast | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | Cervix | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Cervix | CC |
SELE | GLG1 | SELE_GLG1 | SELE | Endometrium | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Endometrium | AEH |
SELE | GLG1 | SELE_GLG1 | SELE | Endometrium | EEC |
SELE | GLG1 | SELE_GLG1 | SELE | Esophagus | ESCC |
SELE | GLG1 | SELE_GLG1 | SELE | GC | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | HNSCC | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | HNSCC | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | HNSCC | OSCC |
SELE | GLG1 | SELE_GLG1 | SELE | HNSCC | Precancer |
SELE | GLG1 | SELE_GLG1 | SELE | Prostate | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Prostate | BPH |
SELE | GLG1 | SELE_GLG1 | SELE | Prostate | Healthy |
SELE | GLG1 | SELE_GLG1 | SELE | Prostate | Tumor |
SELE | GLG1 | SELE_GLG1 | SELE | Skin | ADJ |
SELE | GLG1 | SELE_GLG1 | SELE | Skin | AK |
SELE | GLG1 | SELE_GLG1 | SELE | Skin | cSCC |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GLG1 | SNV | Missense_Mutation | c.1717C>G | p.Arg573Gly | p.R573G | Q92896 | protein_coding | deleterious(0.01) | possibly_damaging(0.524) | TCGA-A7-A0CE-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
GLG1 | SNV | Missense_Mutation | novel | c.2081N>A | p.Arg694Lys | p.R694K | Q92896 | protein_coding | tolerated(0.25) | possibly_damaging(0.553) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
GLG1 | SNV | Missense_Mutation | rs763398161 | c.1621N>A | p.Asp541Asn | p.D541N | Q92896 | protein_coding | tolerated(0.2) | benign(0.122) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
GLG1 | SNV | Missense_Mutation | novel | c.3442C>A | p.Leu1148Ile | p.L1148I | Q92896 | protein_coding | tolerated(0.12) | probably_damaging(0.986) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GLG1 | SNV | Missense_Mutation | c.2171N>G | p.Asn724Ser | p.N724S | Q92896 | protein_coding | tolerated(0.05) | probably_damaging(0.939) | TCGA-D8-A1JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD | |
GLG1 | deletion | Frame_Shift_Del | c.2499_2500delCT | p.Phe833LeufsTer32 | p.F833Lfs*32 | Q92896 | protein_coding | TCGA-AC-A23C-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | chemo | CR | |||
GLG1 | SNV | Missense_Mutation | novel | c.3331C>T | p.Arg1111Cys | p.R1111C | Q92896 | protein_coding | deleterious(0.01) | probably_damaging(0.95) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GLG1 | SNV | Missense_Mutation | c.623N>A | p.Arg208Gln | p.R208Q | Q92896 | protein_coding | tolerated(0.12) | possibly_damaging(0.749) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GLG1 | SNV | Missense_Mutation | novel | c.2575T>C | p.Cys859Arg | p.C859R | Q92896 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
GLG1 | SNV | Missense_Mutation | c.1043G>A | p.Ser348Asn | p.S348N | Q92896 | protein_coding | deleterious(0) | probably_damaging(0.97) | TCGA-A6-3809-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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