Tissue | Expression Dynamics | Abbreviation |
Cervix | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Cervix/GAREM1_pca_on_diff_genes.png) | CC: Cervix cancer |
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions |
N_HPV: HPV-infected normal cervix |
Colorectum (GSE201348) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Becker/GAREM1_pca_on_diff_genes.png) | FAP: Familial adenomatous polyposis |
CRC: Colorectal cancer |
Colorectum (HTA11) | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Colorectum/Chen/GAREM1_pca_on_diff_genes.png) | AD: Adenomas |
SER: Sessile serrated lesions |
MSI-H: Microsatellite-high colorectal cancer |
MSS: Microsatellite stable colorectal cancer |
Endometrium | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Endometrium/GAREM1_pca_on_diff_genes.png) | AEH: Atypical endometrial hyperplasia |
EEC: Endometrioid Cancer |
Liver | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Liver/GAREM1_pca_on_diff_genes.png) | HCC: Hepatocellular carcinoma |
NAFLD: Non-alcoholic fatty liver disease |
Lung | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Lung/GAREM1_pca_on_diff_genes.png) | AAH: Atypical adenomatous hyperplasia |
AIS: Adenocarcinoma in situ |
IAC: Invasive lung adenocarcinoma |
MIA: Minimally invasive adenocarcinoma |
Prostate | ![The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.](images/deg_images/Prostate/GAREM1_pca_on_diff_genes.png) | BPH: Benign Prostatic Hyperplasia |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GAREM1 | SNV | Missense_Mutation | novel | c.561N>G | p.Ile187Met | p.I187M | Q9H706 | protein_coding | deleterious(0.04) | possibly_damaging(0.824) | TCGA-5L-AAT1-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | letrozol | SD |
GAREM1 | SNV | Missense_Mutation | | c.1124N>T | p.Ala375Val | p.A375V | Q9H706 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A2-A0ET-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD |
GAREM1 | SNV | Missense_Mutation | | c.2254N>A | p.Glu752Lys | p.E752K | Q9H706 | protein_coding | tolerated(0.08) | possibly_damaging(0.551) | TCGA-AN-A0FY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GAREM1 | insertion | Nonsense_Mutation | novel | c.941_942insTTTAGGAATTAGAGTTTTACTCTATGTCTGATGAGAACCTC | p.Lys314AsnfsTer11 | p.K314Nfs*11 | Q9H706 | protein_coding | | | TCGA-A2-A0EX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
GAREM1 | insertion | Nonsense_Mutation | novel | c.398_399insATTTGTATGAATCACCGGACCAACGAAAGCATTAGCCT | p.Ser134PhefsTer3 | p.S134Ffs*3 | Q9H706 | protein_coding | | | TCGA-A7-A0CJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
GAREM1 | insertion | Nonsense_Mutation | novel | c.2221_2222insTTGCAGGTGAAGAAGATAATGCAATTCATTAATGGCTGGAGG | p.Thr741delinsIleAlaGlyGluGluAspAsnAlaIleHisTerTrpLeuGluAla | p.T741delinsIAGEEDNAIH*WLEA | Q9H706 | protein_coding | | | TCGA-A7-A0D9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxotere | SD |
GAREM1 | insertion | Nonsense_Mutation | novel | c.1395_1396insACAACAAATTAGCTGGGCGTGGTGGCGGGCGCCTCTAGTCCCAAG | p.His465_Gln466insThrThrAsnTerLeuGlyValValAlaGlyAlaSerSerProLys | p.H465_Q466insTTN*LGVVAGASSPK | Q9H706 | protein_coding | | | TCGA-A8-A07J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
GAREM1 | insertion | Frame_Shift_Ins | novel | c.2104_2105insGGAGGCC | p.Ser702TrpfsTer50 | p.S702Wfs*50 | Q9H706 | protein_coding | | | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
GAREM1 | insertion | Nonsense_Mutation | novel | c.2102_2103insTAATGCAATTCATTAATGG | p.Ser702AsnfsTer5 | p.S702Nfs*5 | Q9H706 | protein_coding | | | TCGA-BH-A0BM-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
GAREM1 | SNV | Missense_Mutation | | c.2506N>A | p.Glu836Lys | p.E836K | Q9H706 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |