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Gene: GAK |
Gene summary for GAK |
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Gene information | Species | Human | Gene symbol | GAK | Gene ID | 2580 |
Gene name | cyclin G associated kinase | |
Gene Alias | DNAJ26 | |
Cytomap | 4p16.3 | |
Gene Type | protein-coding | GO ID | GO:0006457 | UniProtAcc | B4DS37 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2580 | GAK | HTA11_347_2000001011 | Human | Colorectum | AD | 4.18e-06 | 4.77e-01 | -0.1954 |
2580 | GAK | HTA11_696_2000001011 | Human | Colorectum | AD | 7.09e-10 | 5.31e-01 | -0.1464 |
2580 | GAK | HTA11_8622_2000001021 | Human | Colorectum | SER | 8.14e-03 | 1.13e-01 | 0.0528 |
2580 | GAK | A015-C-203 | Human | Colorectum | FAP | 1.07e-15 | 1.46e-01 | -0.1294 |
2580 | GAK | A015-C-204 | Human | Colorectum | FAP | 2.01e-03 | 5.05e-02 | -0.0228 |
2580 | GAK | A002-C-201 | Human | Colorectum | FAP | 8.21e-09 | 1.77e-01 | 0.0324 |
2580 | GAK | A001-C-119 | Human | Colorectum | FAP | 1.90e-05 | 2.65e-01 | -0.1557 |
2580 | GAK | A001-C-108 | Human | Colorectum | FAP | 3.36e-10 | 2.26e-01 | -0.0272 |
2580 | GAK | A002-C-205 | Human | Colorectum | FAP | 6.40e-16 | 1.68e-01 | -0.1236 |
2580 | GAK | A001-C-104 | Human | Colorectum | FAP | 3.80e-02 | 2.41e-01 | 0.0184 |
2580 | GAK | A015-C-006 | Human | Colorectum | FAP | 2.84e-14 | 3.51e-01 | -0.0994 |
2580 | GAK | A015-C-106 | Human | Colorectum | FAP | 9.57e-12 | 2.35e-01 | -0.0511 |
2580 | GAK | A002-C-114 | Human | Colorectum | FAP | 6.64e-15 | 2.53e-01 | -0.1561 |
2580 | GAK | A015-C-104 | Human | Colorectum | FAP | 3.46e-24 | 2.90e-01 | -0.1899 |
2580 | GAK | A001-C-014 | Human | Colorectum | FAP | 1.74e-07 | 9.13e-02 | 0.0135 |
2580 | GAK | A002-C-016 | Human | Colorectum | FAP | 5.86e-14 | 1.79e-02 | 0.0521 |
2580 | GAK | A015-C-002 | Human | Colorectum | FAP | 7.65e-09 | 2.05e-01 | -0.0763 |
2580 | GAK | A001-C-203 | Human | Colorectum | FAP | 2.29e-08 | 1.70e-01 | -0.0481 |
2580 | GAK | A002-C-116 | Human | Colorectum | FAP | 1.86e-19 | -2.06e-01 | -0.0452 |
2580 | GAK | A014-C-008 | Human | Colorectum | FAP | 6.04e-12 | 2.65e-01 | -0.191 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00224115 | Colorectum | CRC | cellular component disassembly | 75/2078 | 443/18723 | 1.26e-04 | 2.42e-03 | 75 |
GO:00109773 | Colorectum | CRC | negative regulation of neuron projection development | 30/2078 | 137/18723 | 1.95e-04 | 3.33e-03 | 30 |
GO:00070344 | Colorectum | CRC | vacuolar transport | 32/2078 | 157/18723 | 4.77e-04 | 6.90e-03 | 32 |
GO:00340672 | Colorectum | CRC | protein localization to Golgi apparatus | 10/2078 | 29/18723 | 7.59e-04 | 9.71e-03 | 10 |
GO:00364652 | Colorectum | CRC | synaptic vesicle recycling | 17/2078 | 75/18723 | 3.04e-03 | 2.71e-02 | 17 |
GO:00070413 | Colorectum | CRC | lysosomal transport | 23/2078 | 114/18723 | 3.20e-03 | 2.79e-02 | 23 |
GO:00512613 | Colorectum | CRC | protein depolymerization | 22/2078 | 114/18723 | 6.73e-03 | 4.77e-02 | 22 |
GO:00484881 | Colorectum | CRC | synaptic vesicle endocytosis | 14/2078 | 62/18723 | 7.05e-03 | 4.92e-02 | 14 |
GO:01402381 | Colorectum | CRC | presynaptic endocytosis | 14/2078 | 62/18723 | 7.05e-03 | 4.92e-02 | 14 |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:0022411111 | Esophagus | ESCC | cellular component disassembly | 305/8552 | 443/18723 | 1.94e-23 | 4.57e-21 | 305 |
GO:0006457110 | Esophagus | ESCC | protein folding | 163/8552 | 212/18723 | 1.13e-20 | 1.74e-18 | 163 |
GO:000703417 | Esophagus | ESCC | vacuolar transport | 119/8552 | 157/18723 | 1.16e-14 | 6.30e-13 | 119 |
GO:0072659110 | Esophagus | ESCC | protein localization to plasma membrane | 193/8552 | 284/18723 | 1.95e-14 | 1.03e-12 | 193 |
GO:001648210 | Esophagus | ESCC | cytosolic transport | 124/8552 | 168/18723 | 9.69e-14 | 4.69e-12 | 124 |
GO:199077819 | Esophagus | ESCC | protein localization to cell periphery | 217/8552 | 333/18723 | 4.08e-13 | 1.88e-11 | 217 |
GO:000689215 | Esophagus | ESCC | post-Golgi vesicle-mediated transport | 82/8552 | 104/18723 | 4.00e-12 | 1.55e-10 | 82 |
GO:003298416 | Esophagus | ESCC | protein-containing complex disassembly | 151/8552 | 224/18723 | 3.45e-11 | 1.15e-09 | 151 |
GO:0061077110 | Esophagus | ESCC | chaperone-mediated protein folding | 56/8552 | 67/18723 | 1.52e-10 | 4.36e-09 | 56 |
GO:00070419 | Esophagus | ESCC | lysosomal transport | 83/8552 | 114/18723 | 3.52e-09 | 7.41e-08 | 83 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GAK | SNV | Missense_Mutation | c.264N>A | p.Phe88Leu | p.F88L | O14976 | protein_coding | tolerated(0.12) | benign(0.046) | TCGA-E2-A1BD-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | SD | |
GAK | deletion | Frame_Shift_Del | novel | c.1400delN | p.Asn467ThrfsTer75 | p.N467Tfs*75 | O14976 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
GAK | deletion | Frame_Shift_Del | novel | c.3405delN | p.Lys1136SerfsTer20 | p.K1136Sfs*20 | O14976 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
GAK | SNV | Missense_Mutation | c.175N>C | p.Asp59His | p.D59H | O14976 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GAK | SNV | Missense_Mutation | c.1273N>A | p.Glu425Lys | p.E425K | O14976 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-JW-A5VL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
GAK | SNV | Missense_Mutation | c.790G>A | p.Glu264Lys | p.E264K | O14976 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-Q1-A5R2-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PR | |
GAK | SNV | Missense_Mutation | novel | c.3386N>A | p.Ala1129Asp | p.A1129D | O14976 | protein_coding | tolerated(0.46) | benign(0.028) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GAK | SNV | Missense_Mutation | novel | c.3242N>G | p.Asp1081Gly | p.D1081G | O14976 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AA-3947-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GAK | SNV | Missense_Mutation | novel | c.524A>G | p.Lys175Arg | p.K175R | O14976 | protein_coding | deleterious(0) | possibly_damaging(0.737) | TCGA-AA-A02E-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
GAK | SNV | Missense_Mutation | c.2249G>A | p.Gly750Glu | p.G750E | O14976 | protein_coding | deleterious(0) | possibly_damaging(0.852) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2580 | GAK | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | SB-202190 | SB-202190 | 22951114 | |
2580 | GAK | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | inhibitor | HTS-466284 | CHEMBL261454 | 19035792 |
2580 | GAK | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | inhibitor | 223366123 | BARICITINIB | |
2580 | GAK | SERINE THREONINE KINASE, DRUGGABLE GENOME, KINASE, ENZYME | inhibitor | 178101952 |
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