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Gene: FSTL1 |
Gene summary for FSTL1 |
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Gene information | Species | Human | Gene symbol | FSTL1 | Gene ID | 11167 |
Gene name | follistatin like 1 | |
Gene Alias | FRP | |
Cytomap | 3q13.33 | |
Gene Type | protein-coding | GO ID | GO:0001667 | UniProtAcc | Q12841 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11167 | FSTL1 | AEH-subject2 | Human | Endometrium | AEH | 1.36e-06 | -2.14e-01 | -0.2525 |
11167 | FSTL1 | AEH-subject3 | Human | Endometrium | AEH | 9.35e-09 | -3.18e-01 | -0.2576 |
11167 | FSTL1 | AEH-subject4 | Human | Endometrium | AEH | 1.02e-03 | 4.94e-02 | -0.2657 |
11167 | FSTL1 | AEH-subject5 | Human | Endometrium | AEH | 4.34e-06 | -1.96e-01 | -0.2953 |
11167 | FSTL1 | EEC-subject1 | Human | Endometrium | EEC | 3.86e-08 | -3.03e-01 | -0.2682 |
11167 | FSTL1 | EEC-subject2 | Human | Endometrium | EEC | 1.28e-21 | -4.73e-01 | -0.2607 |
11167 | FSTL1 | EEC-subject3 | Human | Endometrium | EEC | 4.28e-30 | -2.62e-01 | -0.2525 |
11167 | FSTL1 | EEC-subject4 | Human | Endometrium | EEC | 1.72e-22 | -4.59e-01 | -0.2571 |
11167 | FSTL1 | EEC-subject5 | Human | Endometrium | EEC | 6.26e-29 | -5.55e-01 | -0.249 |
11167 | FSTL1 | GSM5276935 | Human | Endometrium | EEC | 1.15e-21 | -4.98e-01 | -0.123 |
11167 | FSTL1 | GSM6177620_NYU_UCEC1_lib1_lib1 | Human | Endometrium | EEC | 1.15e-21 | -3.16e-01 | -0.1869 |
11167 | FSTL1 | GSM6177620_NYU_UCEC1_lib2_lib2 | Human | Endometrium | EEC | 3.03e-25 | -5.46e-01 | -0.1875 |
11167 | FSTL1 | GSM6177620_NYU_UCEC1_lib3_lib3 | Human | Endometrium | EEC | 9.52e-27 | -4.05e-01 | -0.1883 |
11167 | FSTL1 | GSM6177621_NYU_UCEC2_lib1_lib1 | Human | Endometrium | EEC | 1.57e-27 | -3.65e-01 | -0.1934 |
11167 | FSTL1 | GSM6177622_NYU_UCEC3_lib1_lib1 | Human | Endometrium | EEC | 7.42e-43 | -5.13e-01 | -0.1917 |
11167 | FSTL1 | GSM6177622_NYU_UCEC3_lib2_lib2 | Human | Endometrium | EEC | 9.40e-35 | -4.77e-01 | -0.1916 |
11167 | FSTL1 | GSM6177623_NYU_UCEC3_Vis | Human | Endometrium | EEC | 2.23e-04 | 9.67e-02 | -0.1269 |
11167 | FSTL1 | LZE4T | Human | Esophagus | ESCC | 4.02e-02 | -2.93e-01 | 0.0811 |
11167 | FSTL1 | LZE20T | Human | Esophagus | ESCC | 1.57e-02 | -3.71e-01 | 0.0662 |
11167 | FSTL1 | LZE24T | Human | Esophagus | ESCC | 1.15e-05 | 6.79e-02 | 0.0596 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00902871 | Prostate | Tumor | regulation of cellular response to growth factor stimulus | 74/3246 | 304/18723 | 1.13e-03 | 7.22e-03 | 74 |
GO:009009212 | Prostate | Tumor | regulation of transmembrane receptor protein serine/threonine kinase signaling pathway | 61/3246 | 256/18723 | 4.84e-03 | 2.37e-02 | 61 |
GO:001063124 | Skin | AK | epithelial cell migration | 70/1910 | 357/18723 | 5.88e-08 | 2.95e-06 | 70 |
GO:009013224 | Skin | AK | epithelium migration | 70/1910 | 360/18723 | 8.28e-08 | 3.89e-06 | 70 |
GO:009013024 | Skin | AK | tissue migration | 70/1910 | 365/18723 | 1.45e-07 | 6.29e-06 | 70 |
GO:000166726 | Skin | AK | ameboidal-type cell migration | 85/1910 | 475/18723 | 1.72e-07 | 7.24e-06 | 85 |
GO:004887228 | Skin | AK | homeostasis of number of cells | 56/1910 | 272/18723 | 2.33e-07 | 9.18e-06 | 56 |
GO:00902873 | Skin | AK | regulation of cellular response to growth factor stimulus | 53/1910 | 304/18723 | 7.10e-05 | 1.02e-03 | 53 |
GO:000315819 | Skin | AK | endothelium development | 29/1910 | 136/18723 | 9.31e-05 | 1.25e-03 | 29 |
GO:004544616 | Skin | AK | endothelial cell differentiation | 26/1910 | 118/18723 | 1.20e-04 | 1.50e-03 | 26 |
GO:004354216 | Skin | AK | endothelial cell migration | 48/1910 | 279/18723 | 2.10e-04 | 2.37e-03 | 48 |
GO:000717817 | Skin | AK | transmembrane receptor protein serine/threonine kinase signaling pathway | 57/1910 | 355/18723 | 3.69e-04 | 3.61e-03 | 57 |
GO:00717725 | Skin | AK | response to BMP | 30/1910 | 165/18723 | 1.24e-03 | 9.40e-03 | 30 |
GO:00717735 | Skin | AK | cellular response to BMP stimulus | 30/1910 | 165/18723 | 1.24e-03 | 9.40e-03 | 30 |
GO:00305102 | Skin | AK | regulation of BMP signaling pathway | 20/1910 | 96/18723 | 1.46e-03 | 1.06e-02 | 20 |
GO:00305094 | Skin | AK | BMP signaling pathway | 27/1910 | 152/18723 | 2.97e-03 | 1.87e-02 | 27 |
GO:0010631110 | Skin | SCCIS | epithelial cell migration | 42/919 | 357/18723 | 1.45e-07 | 1.74e-05 | 42 |
GO:0090132110 | Skin | SCCIS | epithelium migration | 42/919 | 360/18723 | 1.82e-07 | 1.97e-05 | 42 |
GO:0090130110 | Skin | SCCIS | tissue migration | 42/919 | 365/18723 | 2.66e-07 | 2.62e-05 | 42 |
GO:0001667111 | Skin | SCCIS | ameboidal-type cell migration | 48/919 | 475/18723 | 1.78e-06 | 9.73e-05 | 48 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FSTL1 | SNV | Missense_Mutation | rs748013373 | c.365N>A | p.Arg122Gln | p.R122Q | Q12841 | protein_coding | deleterious(0) | possibly_damaging(0.797) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FSTL1 | insertion | Frame_Shift_Ins | novel | c.474_475insC | p.Gly159ArgfsTer2 | p.G159Rfs*2 | Q12841 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
FSTL1 | insertion | Frame_Shift_Ins | novel | c.472_473insGTGCCCCAGGAGACCAAGGAGGCTCTCTCTGCTCAATACAGTAC | p.Asn158SerfsTer27 | p.N158Sfs*27 | Q12841 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
FSTL1 | SNV | Missense_Mutation | c.688N>C | p.Glu230Gln | p.E230Q | Q12841 | protein_coding | tolerated(0.17) | benign(0.167) | TCGA-VS-A9UI-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
FSTL1 | SNV | Missense_Mutation | rs143843913 | c.716N>T | p.Thr239Met | p.T239M | Q12841 | protein_coding | tolerated(0.08) | possibly_damaging(0.891) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FSTL1 | SNV | Missense_Mutation | c.682N>T | p.Pro228Ser | p.P228S | Q12841 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3846-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FSTL1 | SNV | Missense_Mutation | c.556G>T | p.Asp186Tyr | p.D186Y | Q12841 | protein_coding | deleterious(0) | possibly_damaging(0.541) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FSTL1 | SNV | Missense_Mutation | c.674N>A | p.Ser225Tyr | p.S225Y | Q12841 | protein_coding | tolerated(0.16) | benign(0.005) | TCGA-AA-3994-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | CR | |
FSTL1 | SNV | Missense_Mutation | rs376856380 | c.371N>A | p.Arg124His | p.R124H | Q12841 | protein_coding | tolerated(0.2) | possibly_damaging(0.828) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FSTL1 | SNV | Missense_Mutation | rs554312023 | c.368G>A | p.Arg123His | p.R123H | Q12841 | protein_coding | tolerated(0.15) | benign(0.012) | TCGA-AG-3881-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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