GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:19030522 | Colorectum | MSS | positive regulation of proteolysis involved in cellular protein catabolic process | 48/3467 | 133/18723 | 1.21e-06 | 4.06e-05 | 48 |
GO:20000602 | Colorectum | MSS | positive regulation of ubiquitin-dependent protein catabolic process | 39/3467 | 107/18723 | 8.92e-06 | 2.19e-04 | 39 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
GO:00018922 | Colorectum | MSS | embryonic placenta development | 32/3467 | 82/18723 | 1.11e-05 | 2.64e-04 | 32 |
GO:00486082 | Colorectum | MSS | reproductive structure development | 113/3467 | 424/18723 | 1.94e-05 | 4.18e-04 | 113 |
GO:19018002 | Colorectum | MSS | positive regulation of proteasomal protein catabolic process | 40/3467 | 114/18723 | 1.96e-05 | 4.19e-04 | 40 |
GO:00313462 | Colorectum | MSS | positive regulation of cell projection organization | 96/3467 | 353/18723 | 3.44e-05 | 6.70e-04 | 96 |
GO:00017012 | Colorectum | MSS | in utero embryonic development | 99/3467 | 367/18723 | 3.71e-05 | 7.10e-04 | 99 |
GO:00107692 | Colorectum | MSS | regulation of cell morphogenesis involved in differentiation | 34/3467 | 96/18723 | 6.43e-05 | 1.12e-03 | 34 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:00324362 | Colorectum | MSS | positive regulation of proteasomal ubiquitin-dependent protein catabolic process | 32/3467 | 90/18723 | 9.56e-05 | 1.50e-03 | 32 |
GO:00107702 | Colorectum | MSS | positive regulation of cell morphogenesis involved in differentiation | 29/3467 | 79/18723 | 1.04e-04 | 1.63e-03 | 29 |
GO:00107202 | Colorectum | MSS | positive regulation of cell development | 81/3467 | 298/18723 | 1.38e-04 | 2.06e-03 | 81 |
GO:00507671 | Colorectum | MSS | regulation of neurogenesis | 94/3467 | 364/18723 | 3.12e-04 | 4.06e-03 | 94 |
GO:00607112 | Colorectum | MSS | labyrinthine layer development | 18/3467 | 44/18723 | 4.62e-04 | 5.46e-03 | 18 |
GO:00163582 | Colorectum | MSS | dendrite development | 65/3467 | 243/18723 | 9.41e-04 | 9.50e-03 | 65 |
GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
GO:0050769 | Colorectum | MSS | positive regulation of neurogenesis | 57/3467 | 225/18723 | 6.60e-03 | 4.38e-02 | 57 |
GO:0051960 | Colorectum | MSS | regulation of nervous system development | 103/3467 | 443/18723 | 6.68e-03 | 4.38e-02 | 103 |
GO:00098964 | Colorectum | FAP | positive regulation of catabolic process | 126/2622 | 492/18723 | 3.76e-12 | 2.56e-09 | 126 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04120 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041201 | Colorectum | AD | Ubiquitin mediated proteolysis | 58/2092 | 142/8465 | 1.46e-05 | 1.53e-04 | 9.76e-05 | 58 |
hsa041202 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa041203 | Colorectum | SER | Ubiquitin mediated proteolysis | 39/1580 | 142/8465 | 6.18e-03 | 3.66e-02 | 2.66e-02 | 39 |
hsa041204 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041205 | Colorectum | MSS | Ubiquitin mediated proteolysis | 55/1875 | 142/8465 | 5.02e-06 | 6.00e-05 | 3.68e-05 | 55 |
hsa041206 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa041207 | Colorectum | FAP | Ubiquitin mediated proteolysis | 51/1404 | 142/8465 | 1.55e-08 | 5.84e-07 | 3.55e-07 | 51 |
hsa041208 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
hsa041209 | Colorectum | CRC | Ubiquitin mediated proteolysis | 42/1091 | 142/8465 | 9.98e-08 | 6.67e-06 | 4.52e-06 | 42 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXW8 | SNV | Missense_Mutation | rs368052577 | c.1670N>A | p.Arg557His | p.R557H | Q8N3Y1 | protein_coding | tolerated(0.6) | benign(0.003) | TCGA-A2-A0D0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
FBXW8 | SNV | Missense_Mutation | | c.1148N>T | p.Ala383Val | p.A383V | Q8N3Y1 | protein_coding | tolerated(1) | benign(0) | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXW8 | SNV | Missense_Mutation | rs779200230 | c.364N>A | p.Glu122Lys | p.E122K | Q8N3Y1 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FBXW8 | SNV | Missense_Mutation | rs753804526 | c.592N>T | p.Arg198Cys | p.R198C | Q8N3Y1 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-E2-A1LB-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
FBXW8 | SNV | Missense_Mutation | | c.1175N>C | p.Asp392Ala | p.D392A | Q8N3Y1 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-E9-A295-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
FBXW8 | SNV | Missense_Mutation | rs773598560 | c.1626N>G | p.Asp542Glu | p.D542E | Q8N3Y1 | protein_coding | tolerated(0.53) | benign(0.055) | TCGA-EW-A1PD-01 | Breast | breast invasive carcinoma | Male | <65 | I/II | Chemotherapy | docetaxel | SD |
FBXW8 | SNV | Missense_Mutation | | c.1174N>A | p.Asp392Asn | p.D392N | Q8N3Y1 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
FBXW8 | SNV | Missense_Mutation | novel | c.1064G>C | p.Arg355Thr | p.R355T | Q8N3Y1 | protein_coding | tolerated(0.68) | benign(0.001) | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
FBXW8 | SNV | Missense_Mutation | rs868211841 | c.1588G>A | p.Ala530Thr | p.A530T | Q8N3Y1 | protein_coding | deleterious(0) | possibly_damaging(0.904) | TCGA-EA-A50E-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD |
FBXW8 | SNV | Missense_Mutation | rs758915610 | c.713N>A | p.Arg238His | p.R238H | Q8N3Y1 | protein_coding | tolerated(0.07) | benign(0.241) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |