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Gene: FBXL17 |
Gene summary for FBXL17 |
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Gene information | Species | Human | Gene symbol | FBXL17 | Gene ID | 64839 |
Gene name | F-box and leucine rich repeat protein 17 | |
Gene Alias | FBXO13 | |
Cytomap | 5q21.3 | |
Gene Type | protein-coding | GO ID | GO:0000086 | UniProtAcc | Q9UF56 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
64839 | FBXL17 | CCI_2 | Human | Cervix | CC | 1.34e-13 | 1.12e+00 | 0.5249 |
64839 | FBXL17 | CCI_3 | Human | Cervix | CC | 1.06e-16 | 1.03e+00 | 0.516 |
64839 | FBXL17 | HTA11_3410_2000001011 | Human | Colorectum | AD | 7.31e-39 | -8.45e-01 | 0.0155 |
64839 | FBXL17 | HTA11_2487_2000001011 | Human | Colorectum | SER | 2.81e-03 | -5.13e-01 | -0.1808 |
64839 | FBXL17 | HTA11_2951_2000001011 | Human | Colorectum | AD | 1.18e-07 | -1.07e+00 | 0.0216 |
64839 | FBXL17 | HTA11_3361_2000001011 | Human | Colorectum | AD | 3.22e-16 | -8.42e-01 | -0.1207 |
64839 | FBXL17 | HTA11_696_2000001011 | Human | Colorectum | AD | 2.82e-13 | -4.16e-01 | -0.1464 |
64839 | FBXL17 | HTA11_866_2000001011 | Human | Colorectum | AD | 9.10e-07 | -3.11e-01 | -0.1001 |
64839 | FBXL17 | HTA11_1391_2000001011 | Human | Colorectum | AD | 1.82e-06 | -5.06e-01 | -0.059 |
64839 | FBXL17 | HTA11_5212_2000001011 | Human | Colorectum | AD | 4.82e-08 | -7.64e-01 | -0.2061 |
64839 | FBXL17 | HTA11_866_3004761011 | Human | Colorectum | AD | 2.96e-16 | -7.51e-01 | 0.096 |
64839 | FBXL17 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.04e-04 | -5.86e-01 | 0.0446 |
64839 | FBXL17 | HTA11_9408_2000001011 | Human | Colorectum | AD | 3.19e-02 | -8.56e-01 | 0.0451 |
64839 | FBXL17 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.43e-10 | -8.39e-01 | 0.0528 |
64839 | FBXL17 | HTA11_10711_2000001011 | Human | Colorectum | AD | 6.32e-09 | -5.81e-01 | 0.0338 |
64839 | FBXL17 | HTA11_7696_3000711011 | Human | Colorectum | AD | 7.56e-26 | -6.51e-01 | 0.0674 |
64839 | FBXL17 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.84e-05 | -5.58e-01 | 0.0112 |
64839 | FBXL17 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.08e-02 | -9.48e-01 | 0.0397 |
64839 | FBXL17 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.10e-04 | -4.21e-01 | 0.0588 |
64839 | FBXL17 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 4.51e-20 | -5.25e-01 | 0.294 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00065153 | Liver | NAFLD | protein quality control for misfolded or incompletely synthesized proteins | 10/1882 | 28/18723 | 2.46e-04 | 4.09e-03 | 10 |
GO:00488632 | Liver | NAFLD | stem cell differentiation | 33/1882 | 206/18723 | 4.81e-03 | 3.81e-02 | 33 |
GO:001049812 | Liver | Cirrhotic | proteasomal protein catabolic process | 216/4634 | 490/18723 | 2.52e-21 | 9.29e-19 | 216 |
GO:004316112 | Liver | Cirrhotic | proteasome-mediated ubiquitin-dependent protein catabolic process | 184/4634 | 412/18723 | 4.52e-19 | 8.85e-17 | 184 |
GO:000762312 | Liver | Cirrhotic | circadian rhythm | 84/4634 | 210/18723 | 7.04e-07 | 1.50e-05 | 84 |
GO:000020911 | Liver | Cirrhotic | protein polyubiquitination | 89/4634 | 236/18723 | 6.09e-06 | 9.80e-05 | 89 |
GO:004851111 | Liver | Cirrhotic | rhythmic process | 103/4634 | 298/18723 | 8.47e-05 | 9.19e-04 | 103 |
GO:00447721 | Liver | Cirrhotic | mitotic cell cycle phase transition | 139/4634 | 424/18723 | 1.02e-04 | 1.06e-03 | 139 |
GO:000651511 | Liver | Cirrhotic | protein quality control for misfolded or incompletely synthesized proteins | 16/4634 | 28/18723 | 2.53e-04 | 2.27e-03 | 16 |
GO:00427525 | Liver | Cirrhotic | regulation of circadian rhythm | 45/4634 | 121/18723 | 1.55e-03 | 1.01e-02 | 45 |
GO:004886311 | Liver | Cirrhotic | stem cell differentiation | 66/4634 | 206/18723 | 1.06e-02 | 4.68e-02 | 66 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
GO:004316122 | Liver | HCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 299/7958 | 412/18723 | 7.82e-36 | 8.27e-33 | 299 |
GO:000020921 | Liver | HCC | protein polyubiquitination | 151/7958 | 236/18723 | 1.90e-11 | 7.59e-10 | 151 |
GO:00447722 | Liver | HCC | mitotic cell cycle phase transition | 240/7958 | 424/18723 | 2.47e-09 | 6.84e-08 | 240 |
GO:000651521 | Liver | HCC | protein quality control for misfolded or incompletely synthesized proteins | 24/7958 | 28/18723 | 3.01e-06 | 3.99e-05 | 24 |
GO:000762321 | Liver | HCC | circadian rhythm | 117/7958 | 210/18723 | 7.29e-05 | 6.54e-04 | 117 |
GO:004851121 | Liver | HCC | rhythmic process | 156/7958 | 298/18723 | 3.54e-04 | 2.46e-03 | 156 |
GO:0000086 | Liver | HCC | G2/M transition of mitotic cell cycle | 75/7958 | 137/18723 | 2.52e-03 | 1.22e-02 | 75 |
GO:00093146 | Liver | HCC | response to radiation | 223/7958 | 456/18723 | 3.08e-03 | 1.43e-02 | 223 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXL17 | SNV | Missense_Mutation | c.1613N>T | p.Lys538Met | p.K538M | Q9UF56 | protein_coding | deleterious(0.01) | benign(0.259) | TCGA-C8-A12L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBXL17 | SNV | Missense_Mutation | c.1879T>C | p.Cys627Arg | p.C627R | Q9UF56 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-E9-A1R2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxotere | CR | |
FBXL17 | insertion | Nonsense_Mutation | novel | c.1845_1846insCTGTAGAACCAGCCAGGGATGTGAGCATGAGTTTAGGAAATGGTGT | p.Ser616LeufsTer2 | p.S616Lfs*2 | Q9UF56 | protein_coding | TCGA-AO-A0JB-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | ||
FBXL17 | SNV | Missense_Mutation | c.1643G>A | p.Arg548His | p.R548H | Q9UF56 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
FBXL17 | SNV | Missense_Mutation | c.1616T>C | p.Leu539Pro | p.L539P | Q9UF56 | protein_coding | deleterious(0.01) | probably_damaging(0.998) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
FBXL17 | SNV | Missense_Mutation | novel | c.1479A>C | p.Gln493His | p.Q493H | Q9UF56 | protein_coding | deleterious(0.04) | probably_damaging(0.993) | TCGA-AA-3862-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
FBXL17 | SNV | Missense_Mutation | rs201479758 | c.1972N>A | p.Glu658Lys | p.E658K | Q9UF56 | protein_coding | tolerated(0.14) | benign(0.373) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXL17 | SNV | Missense_Mutation | novel | c.1033N>A | p.Ala345Thr | p.A345T | Q9UF56 | protein_coding | deleterious(0) | probably_damaging(0.921) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR |
FBXL17 | SNV | Missense_Mutation | novel | c.1402N>T | p.Asp468Tyr | p.D468Y | Q9UF56 | protein_coding | tolerated(0.21) | benign(0.106) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FBXL17 | SNV | Missense_Mutation | novel | c.1716N>G | p.Asn572Lys | p.N572K | Q9UF56 | protein_coding | deleterious(0.01) | possibly_damaging(0.815) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
64839 | FBXL17 | TUMOR SUPPRESSOR | hydrochlorothiazide | HYDROCHLOROTHIAZIDE |
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