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Gene: ESRRA |
Gene summary for ESRRA |
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Gene information | Species | Human | Gene symbol | ESRRA | Gene ID | 2101 |
Gene name | estrogen related receptor alpha | |
Gene Alias | ERR1 | |
Cytomap | 11q13.1 | |
Gene Type | protein-coding | GO ID | GO:0001501 | UniProtAcc | P11474 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2101 | ESRRA | HTA11_3410_2000001011 | Human | Colorectum | AD | 4.78e-06 | -3.46e-01 | 0.0155 |
2101 | ESRRA | HTA11_866_3004761011 | Human | Colorectum | AD | 2.65e-03 | -3.43e-01 | 0.096 |
2101 | ESRRA | HTA11_6818_2000001021 | Human | Colorectum | AD | 2.22e-02 | -4.43e-01 | 0.0588 |
2101 | ESRRA | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.42e-11 | -4.33e-01 | 0.294 |
2101 | ESRRA | F007 | Human | Colorectum | FAP | 1.08e-05 | -4.58e-01 | 0.1176 |
2101 | ESRRA | A002-C-010 | Human | Colorectum | FAP | 1.31e-02 | -2.89e-01 | 0.242 |
2101 | ESRRA | A001-C-207 | Human | Colorectum | FAP | 1.18e-04 | -3.02e-01 | 0.1278 |
2101 | ESRRA | A015-C-203 | Human | Colorectum | FAP | 1.04e-21 | -1.59e-01 | -0.1294 |
2101 | ESRRA | A015-C-204 | Human | Colorectum | FAP | 2.23e-02 | -1.02e-01 | -0.0228 |
2101 | ESRRA | A014-C-040 | Human | Colorectum | FAP | 3.68e-02 | -2.59e-01 | -0.1184 |
2101 | ESRRA | A002-C-201 | Human | Colorectum | FAP | 7.18e-09 | -1.94e-01 | 0.0324 |
2101 | ESRRA | A002-C-203 | Human | Colorectum | FAP | 1.95e-04 | -1.59e-01 | 0.2786 |
2101 | ESRRA | A001-C-119 | Human | Colorectum | FAP | 1.07e-10 | -4.90e-01 | -0.1557 |
2101 | ESRRA | A001-C-108 | Human | Colorectum | FAP | 4.25e-18 | -4.43e-01 | -0.0272 |
2101 | ESRRA | A002-C-205 | Human | Colorectum | FAP | 5.76e-19 | -4.61e-01 | -0.1236 |
2101 | ESRRA | A001-C-104 | Human | Colorectum | FAP | 1.17e-08 | -3.38e-01 | 0.0184 |
2101 | ESRRA | A015-C-005 | Human | Colorectum | FAP | 4.33e-05 | -2.74e-01 | -0.0336 |
2101 | ESRRA | A015-C-006 | Human | Colorectum | FAP | 1.42e-09 | -2.85e-01 | -0.0994 |
2101 | ESRRA | A015-C-106 | Human | Colorectum | FAP | 2.30e-05 | -1.26e-01 | -0.0511 |
2101 | ESRRA | A002-C-114 | Human | Colorectum | FAP | 2.12e-12 | -2.88e-01 | -0.1561 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00456675 | Esophagus | ESCC | regulation of osteoblast differentiation | 77/8552 | 132/18723 | 2.28e-03 | 1.00e-02 | 77 |
GO:000975516 | Esophagus | ESCC | hormone-mediated signaling pathway | 106/8552 | 190/18723 | 3.13e-03 | 1.30e-02 | 106 |
GO:000276115 | Esophagus | ESCC | regulation of myeloid leukocyte differentiation | 69/8552 | 120/18723 | 6.00e-03 | 2.21e-02 | 69 |
GO:00512161 | Esophagus | ESCC | cartilage development | 103/8552 | 190/18723 | 1.08e-02 | 3.67e-02 | 103 |
GO:00303165 | Esophagus | ESCC | osteoclast differentiation | 54/8552 | 94/18723 | 1.43e-02 | 4.65e-02 | 54 |
GO:004854512 | Liver | Cirrhotic | response to steroid hormone | 146/4634 | 339/18723 | 7.87e-14 | 6.76e-12 | 146 |
GO:007138312 | Liver | Cirrhotic | cellular response to steroid hormone stimulus | 90/4634 | 204/18723 | 1.04e-09 | 4.70e-08 | 90 |
GO:003052212 | Liver | Cirrhotic | intracellular receptor signaling pathway | 105/4634 | 265/18723 | 5.44e-08 | 1.69e-06 | 105 |
GO:004343412 | Liver | Cirrhotic | response to peptide hormone | 149/4634 | 414/18723 | 1.70e-07 | 4.49e-06 | 149 |
GO:007137511 | Liver | Cirrhotic | cellular response to peptide hormone stimulus | 110/4634 | 290/18723 | 3.73e-07 | 8.82e-06 | 110 |
GO:190165311 | Liver | Cirrhotic | cellular response to peptide | 129/4634 | 359/18723 | 1.23e-06 | 2.49e-05 | 129 |
GO:003009912 | Liver | Cirrhotic | myeloid cell differentiation | 135/4634 | 381/18723 | 1.69e-06 | 3.22e-05 | 135 |
GO:003286911 | Liver | Cirrhotic | cellular response to insulin stimulus | 80/4634 | 203/18723 | 2.55e-06 | 4.63e-05 | 80 |
GO:004340111 | Liver | Cirrhotic | steroid hormone mediated signaling pathway | 58/4634 | 136/18723 | 3.44e-06 | 5.95e-05 | 58 |
GO:003286811 | Liver | Cirrhotic | response to insulin | 95/4634 | 264/18723 | 2.77e-05 | 3.54e-04 | 95 |
GO:000975511 | Liver | Cirrhotic | hormone-mediated signaling pathway | 71/4634 | 190/18723 | 7.09e-05 | 7.98e-04 | 71 |
GO:19000782 | Liver | Cirrhotic | positive regulation of cellular response to insulin stimulus | 15/4634 | 25/18723 | 1.88e-04 | 1.75e-03 | 15 |
GO:00016495 | Liver | Cirrhotic | osteoblast differentiation | 80/4634 | 229/18723 | 3.39e-04 | 2.91e-03 | 80 |
GO:00323551 | Liver | Cirrhotic | response to estradiol | 51/4634 | 141/18723 | 1.60e-03 | 1.04e-02 | 51 |
GO:00015035 | Liver | Cirrhotic | ossification | 127/4634 | 408/18723 | 1.89e-03 | 1.19e-02 | 127 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ESRRA | insertion | Frame_Shift_Ins | novel | c.278_279insAGAGA | p.Ala94GlufsTer103 | p.A94Efs*103 | P11474 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | ||
ESRRA | SNV | Missense_Mutation | c.902N>A | p.Gly301Asp | p.G301D | P11474 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
ESRRA | SNV | Missense_Mutation | c.775N>C | p.Ser259Pro | p.S259P | P11474 | protein_coding | deleterious(0.04) | probably_damaging(1) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ESRRA | SNV | Missense_Mutation | c.779N>C | p.Val260Ala | p.V260A | P11474 | protein_coding | deleterious(0.01) | possibly_damaging(0.831) | TCGA-DM-A0XF-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | mayo | CR | |
ESRRA | SNV | Missense_Mutation | c.1255G>A | p.Glu419Lys | p.E419K | P11474 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AG-4005-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folinic | CR | |
ESRRA | SNV | Missense_Mutation | c.16G>A | p.Val6Met | p.V6M | P11474 | protein_coding | tolerated_low_confidence(0.1) | benign(0.012) | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
ESRRA | SNV | Missense_Mutation | rs767507136 | c.826N>T | p.Arg276Cys | p.R276C | P11474 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-EI-6882-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ESRRA | SNV | Missense_Mutation | rs45585533 | c.518N>T | p.Pro173Leu | p.P173L | P11474 | protein_coding | tolerated(0.44) | benign(0.003) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ESRRA | SNV | Missense_Mutation | novel | c.972N>T | p.Glu324Asp | p.E324D | P11474 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
ESRRA | SNV | Missense_Mutation | novel | c.47A>C | p.Glu16Ala | p.E16A | P11474 | protein_coding | deleterious_low_confidence(0) | possibly_damaging(0.625) | TCGA-BS-A0U8-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | D-5519 | |||
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | ESTRADIOL | ESTRADIOL | 23448346 | |
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | antagonist | 135651333 | CHEMBL189753 | |
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | Pregnenolone | PREGNENOLONE | ||
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | Rimexolone | RIMEXOLONE | ||
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | FULVESTRANT | FULVESTRANT | 23448346 | |
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | 135650300 | GENISTEIN | |
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | Dexamethasone palmitate | |||
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | 135649823 | ||
2101 | ESRRA | NUCLEAR HORMONE RECEPTOR, DRUGGABLE GENOME | agonist | 135649858 | DAIDZEIN |
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