GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:007149619 | Prostate | Tumor | cellular response to external stimulus | 103/3246 | 320/18723 | 5.29e-11 | 3.41e-09 | 103 |
GO:003096814 | Prostate | Tumor | endoplasmic reticulum unfolded protein response | 37/3246 | 74/18723 | 1.19e-10 | 7.26e-09 | 37 |
GO:004328119 | Prostate | Tumor | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 74/3246 | 209/18723 | 2.29e-10 | 1.33e-08 | 74 |
GO:003596719 | Prostate | Tumor | cellular response to topologically incorrect protein | 49/3246 | 116/18723 | 2.68e-10 | 1.48e-08 | 49 |
GO:005254819 | Prostate | Tumor | regulation of endopeptidase activity | 126/3246 | 432/18723 | 5.86e-10 | 3.01e-08 | 126 |
GO:200011619 | Prostate | Tumor | regulation of cysteine-type endopeptidase activity | 79/3246 | 235/18723 | 9.68e-10 | 4.66e-08 | 79 |
GO:190018014 | Prostate | Tumor | regulation of protein localization to nucleus | 53/3246 | 136/18723 | 1.72e-09 | 7.91e-08 | 53 |
GO:190018214 | Prostate | Tumor | positive regulation of protein localization to nucleus | 39/3246 | 87/18723 | 2.24e-09 | 9.59e-08 | 39 |
GO:001095219 | Prostate | Tumor | positive regulation of peptidase activity | 68/3246 | 197/18723 | 4.09e-09 | 1.66e-07 | 68 |
GO:004594712 | Prostate | Tumor | negative regulation of translational initiation | 15/3246 | 19/18723 | 7.16e-09 | 2.75e-07 | 15 |
GO:003166818 | Prostate | Tumor | cellular response to extracellular stimulus | 78/3246 | 246/18723 | 2.34e-08 | 8.08e-07 | 78 |
GO:004355511 | Prostate | Tumor | regulation of translation in response to stress | 15/3246 | 20/18723 | 2.40e-08 | 8.16e-07 | 15 |
GO:001003819 | Prostate | Tumor | response to metal ion | 107/3246 | 373/18723 | 3.02e-08 | 9.77e-07 | 107 |
GO:190589719 | Prostate | Tumor | regulation of response to endoplasmic reticulum stress | 35/3246 | 82/18723 | 6.76e-08 | 1.95e-06 | 35 |
GO:003166719 | Prostate | Tumor | response to nutrient levels | 127/3246 | 474/18723 | 1.27e-07 | 3.28e-06 | 127 |
GO:000926615 | Prostate | Tumor | response to temperature stimulus | 59/3246 | 178/18723 | 2.14e-07 | 5.21e-06 | 59 |
GO:000698414 | Prostate | Tumor | ER-nucleus signaling pathway | 23/3246 | 46/18723 | 3.87e-07 | 8.56e-06 | 23 |
GO:003424912 | Prostate | Tumor | negative regulation of cellular amide metabolic process | 80/3246 | 273/18723 | 6.33e-07 | 1.32e-05 | 80 |
GO:001095018 | Prostate | Tumor | positive regulation of endopeptidase activity | 58/3246 | 179/18723 | 6.35e-07 | 1.32e-05 | 58 |
GO:004355811 | Prostate | Tumor | regulation of translational initiation in response to stress | 11/3246 | 14/18723 | 9.10e-07 | 1.78e-05 | 11 |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0501228 | Prostate | BPH | Parkinson disease | 143/1718 | 266/8465 | 1.19e-34 | 3.94e-32 | 2.44e-32 | 143 |
hsa0502026 | Prostate | BPH | Prion disease | 141/1718 | 273/8465 | 1.11e-31 | 1.23e-29 | 7.58e-30 | 141 |
hsa0414128 | Prostate | BPH | Protein processing in endoplasmic reticulum | 97/1718 | 174/8465 | 2.37e-25 | 1.30e-23 | 8.07e-24 | 97 |
hsa0501026 | Prostate | BPH | Alzheimer disease | 165/1718 | 384/8465 | 4.03e-25 | 1.66e-23 | 1.03e-23 | 165 |
hsa0501426 | Prostate | BPH | Amyotrophic lateral sclerosis | 151/1718 | 364/8465 | 3.37e-21 | 1.01e-19 | 6.25e-20 | 151 |
hsa0493226 | Prostate | BPH | Non-alcoholic fatty liver disease | 83/1718 | 155/8465 | 2.49e-20 | 6.32e-19 | 3.91e-19 | 83 |
hsa0502226 | Prostate | BPH | Pathways of neurodegeneration - multiple diseases | 180/1718 | 476/8465 | 7.70e-20 | 1.81e-18 | 1.12e-18 | 180 |
hsa0421016 | Prostate | BPH | Apoptosis | 46/1718 | 136/8465 | 1.41e-04 | 8.31e-04 | 5.14e-04 | 46 |
hsa0541728 | Prostate | BPH | Lipid and atherosclerosis | 66/1718 | 215/8465 | 1.68e-04 | 9.56e-04 | 5.92e-04 | 66 |
hsa0413726 | Prostate | BPH | Mitophagy - animal | 28/1718 | 72/8465 | 2.12e-04 | 1.13e-03 | 6.98e-04 | 28 |
hsa051607 | Prostate | BPH | Hepatitis C | 48/1718 | 157/8465 | 1.36e-03 | 5.85e-03 | 3.62e-03 | 48 |
hsa051624 | Prostate | BPH | Measles | 42/1718 | 139/8465 | 3.35e-03 | 1.23e-02 | 7.61e-03 | 42 |
hsa041408 | Prostate | BPH | Autophagy - animal | 42/1718 | 141/8465 | 4.46e-03 | 1.53e-02 | 9.49e-03 | 42 |
hsa05012112 | Prostate | BPH | Parkinson disease | 143/1718 | 266/8465 | 1.19e-34 | 3.94e-32 | 2.44e-32 | 143 |
hsa05020111 | Prostate | BPH | Prion disease | 141/1718 | 273/8465 | 1.11e-31 | 1.23e-29 | 7.58e-30 | 141 |
hsa04141112 | Prostate | BPH | Protein processing in endoplasmic reticulum | 97/1718 | 174/8465 | 2.37e-25 | 1.30e-23 | 8.07e-24 | 97 |
hsa05010111 | Prostate | BPH | Alzheimer disease | 165/1718 | 384/8465 | 4.03e-25 | 1.66e-23 | 1.03e-23 | 165 |
hsa05014111 | Prostate | BPH | Amyotrophic lateral sclerosis | 151/1718 | 364/8465 | 3.37e-21 | 1.01e-19 | 6.25e-20 | 151 |
hsa04932111 | Prostate | BPH | Non-alcoholic fatty liver disease | 83/1718 | 155/8465 | 2.49e-20 | 6.32e-19 | 3.91e-19 | 83 |
hsa05022111 | Prostate | BPH | Pathways of neurodegeneration - multiple diseases | 180/1718 | 476/8465 | 7.70e-20 | 1.81e-18 | 1.12e-18 | 180 |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EIF2AK3 | SNV | Missense_Mutation | novel | c.1153A>C | p.Ser385Arg | p.S385R | Q9NZJ5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-A2-A0CO-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR |
EIF2AK3 | SNV | Missense_Mutation | novel | c.2068A>G | p.Met690Val | p.M690V | Q9NZJ5 | protein_coding | tolerated(0.57) | benign(0.001) | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
EIF2AK3 | SNV | Missense_Mutation | | c.341N>T | p.Arg114Ile | p.R114I | Q9NZJ5 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
EIF2AK3 | SNV | Missense_Mutation | | c.3150N>T | p.Glu1050Asp | p.E1050D | Q9NZJ5 | protein_coding | deleterious(0.01) | probably_damaging(0.979) | TCGA-AN-A0FJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
EIF2AK3 | SNV | Missense_Mutation | novel | c.910N>T | p.Ala304Ser | p.A304S | Q9NZJ5 | protein_coding | tolerated(0.4) | benign(0) | TCGA-LL-A73Z-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD |
EIF2AK3 | insertion | In_Frame_Ins | novel | c.2065_2066insATGAGGACATCAGTGAGT | p.Pro689delinsHisGluAspIleSerGluSer | p.P689delinsHEDISES | Q9NZJ5 | protein_coding | | | TCGA-A8-A09E-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | anastrozole | SD |
EIF2AK3 | insertion | Frame_Shift_Ins | novel | c.1169_1170insAAAATATAAA | p.Met390IlefsTer6 | p.M390Ifs*6 | Q9NZJ5 | protein_coding | | | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF2AK3 | insertion | Nonsense_Mutation | novel | c.2848_2849insGTTATTAGCATATCCAAGGTATCAAACT | p.Val950GlyfsTer3 | p.V950Gfs*3 | Q9NZJ5 | protein_coding | | | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
EIF2AK3 | insertion | Frame_Shift_Ins | novel | c.1492_1493insATGAGAAAGA | p.Val498AspfsTer62 | p.V498Dfs*62 | Q9NZJ5 | protein_coding | | | TCGA-AR-A0U2-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Hormone Therapy | tamoxiphen | PD |
EIF2AK3 | insertion | Frame_Shift_Ins | novel | c.3241_3242insG | p.Asp1081GlyfsTer31 | p.D1081Gfs*31 | Q9NZJ5 | protein_coding | | | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | | Indoline derivative 7 | | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | inhibitor | 336446930 | | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | | Indoline derivative 3 | | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | | Phenylpyrrolidinone derivative 1 | | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | | Tricyclic isoxazoloquinazoline derivative 3 | | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | | Indoline derivative 8 | | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | | Tricyclic isoxazoloquinazoline derivative 1 | | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | inhibitor | 178103351 | CHEMBL2171124 | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | | Phenylpyrrolidinone derivative 5 | | |
9451 | EIF2AK3 | SERINE THREONINE KINASE, KINASE, ENZYME, DRUGGABLE GENOME | | Indoline derivative 10 | | |