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Gene: EBNA1BP2 |
Gene summary for EBNA1BP2 |
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Gene information | Species | Human | Gene symbol | EBNA1BP2 | Gene ID | 10969 |
Gene name | EBNA1 binding protein 2 | |
Gene Alias | EBP2 | |
Cytomap | 1p34.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | H7C2Q8 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10969 | EBNA1BP2 | GSM4909281 | Human | Breast | IDC | 1.70e-04 | 3.05e-01 | 0.21 |
10969 | EBNA1BP2 | GSM4909285 | Human | Breast | IDC | 4.15e-08 | 3.63e-01 | 0.21 |
10969 | EBNA1BP2 | GSM4909286 | Human | Breast | IDC | 1.92e-04 | 1.97e-01 | 0.1081 |
10969 | EBNA1BP2 | GSM4909296 | Human | Breast | IDC | 1.22e-06 | 7.03e-02 | 0.1524 |
10969 | EBNA1BP2 | GSM4909297 | Human | Breast | IDC | 4.34e-04 | -7.39e-03 | 0.1517 |
10969 | EBNA1BP2 | GSM4909311 | Human | Breast | IDC | 3.20e-14 | -4.76e-02 | 0.1534 |
10969 | EBNA1BP2 | GSM4909312 | Human | Breast | IDC | 2.17e-09 | 1.75e-01 | 0.1552 |
10969 | EBNA1BP2 | GSM4909319 | Human | Breast | IDC | 1.46e-21 | -9.22e-02 | 0.1563 |
10969 | EBNA1BP2 | GSM4909321 | Human | Breast | IDC | 9.47e-09 | 1.03e-01 | 0.1559 |
10969 | EBNA1BP2 | brca1 | Human | Breast | Precancer | 4.70e-19 | 6.41e-01 | -0.0338 |
10969 | EBNA1BP2 | brca2 | Human | Breast | Precancer | 1.35e-09 | 3.42e-01 | -0.024 |
10969 | EBNA1BP2 | brca3 | Human | Breast | Precancer | 1.35e-02 | 2.61e-01 | -0.0263 |
10969 | EBNA1BP2 | NCCBC5 | Human | Breast | DCIS | 6.66e-14 | 4.77e-01 | 0.2046 |
10969 | EBNA1BP2 | P1 | Human | Breast | IDC | 1.89e-05 | -2.37e-01 | 0.1527 |
10969 | EBNA1BP2 | DCIS2 | Human | Breast | DCIS | 1.09e-66 | 2.97e-01 | 0.0085 |
10969 | EBNA1BP2 | LZE2T | Human | Esophagus | ESCC | 1.18e-02 | 8.84e-01 | 0.082 |
10969 | EBNA1BP2 | LZE4T | Human | Esophagus | ESCC | 5.76e-12 | 2.27e-01 | 0.0811 |
10969 | EBNA1BP2 | LZE5T | Human | Esophagus | ESCC | 3.11e-03 | 1.93e-01 | 0.0514 |
10969 | EBNA1BP2 | LZE7T | Human | Esophagus | ESCC | 7.12e-06 | 7.21e-01 | 0.0667 |
10969 | EBNA1BP2 | LZE8T | Human | Esophagus | ESCC | 2.19e-08 | 3.21e-01 | 0.067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004225434 | Thyroid | ATC | ribosome biogenesis | 203/6293 | 299/18723 | 3.63e-34 | 4.59e-31 | 203 |
GO:000636432 | Thyroid | ATC | rRNA processing | 157/6293 | 225/18723 | 9.02e-29 | 5.70e-26 | 157 |
GO:001607232 | Thyroid | ATC | rRNA metabolic process | 161/6293 | 236/18723 | 1.02e-27 | 5.89e-25 | 161 |
GO:003447021 | Thyroid | ATC | ncRNA processing | 216/6293 | 395/18723 | 3.14e-18 | 3.98e-16 | 216 |
GO:004227335 | Thyroid | ATC | ribosomal large subunit biogenesis | 57/6293 | 72/18723 | 2.56e-15 | 1.82e-13 | 57 |
GO:003466021 | Thyroid | ATC | ncRNA metabolic process | 240/6293 | 485/18723 | 2.03e-13 | 9.91e-12 | 240 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
EBNA1BP2 | SNV | Missense_Mutation | novel | c.161N>C | p.Gly54Ala | p.G54A | protein_coding | tolerated_low_confidence(0.14) | benign(0.001) | TCGA-A7-A6VW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | CR | |
EBNA1BP2 | SNV | Missense_Mutation | c.1038G>T | p.Lys346Asn | p.K346N | protein_coding | deleterious(0) | possibly_damaging(0.614) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | ||
EBNA1BP2 | SNV | Missense_Mutation | novel | c.1037N>G | p.Lys346Arg | p.K346R | protein_coding | tolerated(0.08) | possibly_damaging(0.614) | TCGA-AA-3852-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
EBNA1BP2 | SNV | Missense_Mutation | novel | c.428N>A | p.Pro143His | p.P143H | protein_coding | deleterious(0.05) | benign(0.014) | TCGA-AA-3950-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
EBNA1BP2 | SNV | Missense_Mutation | rs535649425 | c.530N>A | p.Arg177His | p.R177H | protein_coding | deleterious(0.04) | benign(0.071) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
EBNA1BP2 | SNV | Missense_Mutation | c.22G>A | p.Val8Ile | p.V8I | protein_coding | benign(0.001) | TCGA-AZ-4615-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | xeloda | PD | |||
EBNA1BP2 | SNV | Missense_Mutation | c.445N>C | p.Lys149Gln | p.K149Q | protein_coding | tolerated(0.3) | benign(0.185) | TCGA-CK-6746-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
EBNA1BP2 | SNV | Missense_Mutation | c.97T>C | p.Phe33Leu | p.F33L | protein_coding | benign(0) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |||
EBNA1BP2 | SNV | Missense_Mutation | novel | c.765G>T | p.Lys255Asn | p.K255N | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
EBNA1BP2 | SNV | Missense_Mutation | c.593N>A | p.Ser198Tyr | p.S198Y | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-F5-6813-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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