![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: DMAP1 |
Gene summary for DMAP1 |
![]() |
Gene information | Species | Human | Gene symbol | DMAP1 | Gene ID | 55929 |
Gene name | DNA methyltransferase 1 associated protein 1 | |
Gene Alias | DNMAP1 | |
Cytomap | 1p34.1 | |
Gene Type | protein-coding | GO ID | GO:0000122 | UniProtAcc | Q9NPF5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
55929 | DMAP1 | LZE4T | Human | Esophagus | ESCC | 8.31e-10 | 1.57e-01 | 0.0811 |
55929 | DMAP1 | LZE7T | Human | Esophagus | ESCC | 4.38e-11 | 5.03e-01 | 0.0667 |
55929 | DMAP1 | LZE8T | Human | Esophagus | ESCC | 6.34e-04 | 9.18e-02 | 0.067 |
55929 | DMAP1 | LZE20T | Human | Esophagus | ESCC | 1.99e-03 | 1.86e-01 | 0.0662 |
55929 | DMAP1 | LZE21D1 | Human | Esophagus | HGIN | 2.40e-03 | 1.88e-01 | 0.0632 |
55929 | DMAP1 | LZE22T | Human | Esophagus | ESCC | 4.53e-06 | 3.90e-01 | 0.068 |
55929 | DMAP1 | LZE24T | Human | Esophagus | ESCC | 2.82e-17 | 3.98e-01 | 0.0596 |
55929 | DMAP1 | LZE6T | Human | Esophagus | ESCC | 1.08e-04 | 1.13e-01 | 0.0845 |
55929 | DMAP1 | P1T-E | Human | Esophagus | ESCC | 1.41e-07 | 3.07e-01 | 0.0875 |
55929 | DMAP1 | P2T-E | Human | Esophagus | ESCC | 3.65e-32 | 5.23e-01 | 0.1177 |
55929 | DMAP1 | P4T-E | Human | Esophagus | ESCC | 2.38e-14 | 2.53e-01 | 0.1323 |
55929 | DMAP1 | P5T-E | Human | Esophagus | ESCC | 8.37e-08 | 2.04e-01 | 0.1327 |
55929 | DMAP1 | P8T-E | Human | Esophagus | ESCC | 8.67e-28 | 3.57e-01 | 0.0889 |
55929 | DMAP1 | P9T-E | Human | Esophagus | ESCC | 7.25e-16 | 1.78e-01 | 0.1131 |
55929 | DMAP1 | P10T-E | Human | Esophagus | ESCC | 4.31e-35 | 4.57e-01 | 0.116 |
55929 | DMAP1 | P11T-E | Human | Esophagus | ESCC | 1.04e-07 | 3.78e-01 | 0.1426 |
55929 | DMAP1 | P12T-E | Human | Esophagus | ESCC | 7.29e-21 | 3.05e-01 | 0.1122 |
55929 | DMAP1 | P15T-E | Human | Esophagus | ESCC | 7.62e-14 | 2.81e-01 | 0.1149 |
55929 | DMAP1 | P16T-E | Human | Esophagus | ESCC | 2.10e-18 | 2.51e-01 | 0.1153 |
55929 | DMAP1 | P17T-E | Human | Esophagus | ESCC | 7.47e-09 | 3.81e-01 | 0.1278 |
Page: 1 2 3 4 5 6 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:003450411 | Liver | Cirrhotic | protein localization to nucleus | 113/4634 | 290/18723 | 5.00e-08 | 1.58e-06 | 113 |
GO:00064731 | Liver | Cirrhotic | protein acetylation | 84/4634 | 201/18723 | 7.50e-08 | 2.25e-06 | 84 |
GO:00183941 | Liver | Cirrhotic | peptidyl-lysine acetylation | 73/4634 | 169/18723 | 1.08e-07 | 3.07e-06 | 73 |
GO:004682211 | Liver | Cirrhotic | regulation of nucleocytoplasmic transport | 51/4634 | 106/18723 | 1.54e-07 | 4.12e-06 | 51 |
GO:19001826 | Liver | Cirrhotic | positive regulation of protein localization to nucleus | 44/4634 | 87/18723 | 1.80e-07 | 4.71e-06 | 44 |
GO:19001807 | Liver | Cirrhotic | regulation of protein localization to nucleus | 61/4634 | 136/18723 | 2.39e-07 | 6.06e-06 | 61 |
GO:00435431 | Liver | Cirrhotic | protein acylation | 95/4634 | 243/18723 | 4.73e-07 | 1.07e-05 | 95 |
GO:00182051 | Liver | Cirrhotic | peptidyl-lysine modification | 134/4634 | 376/18723 | 1.29e-06 | 2.59e-05 | 134 |
GO:009730512 | Liver | Cirrhotic | response to alcohol | 96/4634 | 253/18723 | 1.97e-06 | 3.65e-05 | 96 |
GO:00064751 | Liver | Cirrhotic | internal protein amino acid acetylation | 65/4634 | 160/18723 | 6.66e-06 | 1.04e-04 | 65 |
GO:00183931 | Liver | Cirrhotic | internal peptidyl-lysine acetylation | 64/4634 | 158/18723 | 8.75e-06 | 1.29e-04 | 64 |
GO:001657011 | Liver | Cirrhotic | histone modification | 154/4634 | 463/18723 | 1.92e-05 | 2.57e-04 | 154 |
GO:00165731 | Liver | Cirrhotic | histone acetylation | 61/4634 | 152/18723 | 1.97e-05 | 2.62e-04 | 61 |
GO:00170387 | Liver | Cirrhotic | protein import | 77/4634 | 206/18723 | 3.56e-05 | 4.32e-04 | 77 |
GO:0043967 | Liver | Cirrhotic | histone H4 acetylation | 31/4634 | 67/18723 | 1.03e-04 | 1.06e-03 | 31 |
GO:00468246 | Liver | Cirrhotic | positive regulation of nucleocytoplasmic transport | 29/4634 | 62/18723 | 1.34e-04 | 1.31e-03 | 29 |
GO:0043968 | Liver | Cirrhotic | histone H2A acetylation | 11/4634 | 17/18723 | 5.66e-04 | 4.44e-03 | 11 |
GO:19045895 | Liver | Cirrhotic | regulation of protein import | 27/4634 | 63/18723 | 1.23e-03 | 8.30e-03 | 27 |
GO:00423066 | Liver | Cirrhotic | regulation of protein import into nucleus | 25/4634 | 60/18723 | 2.92e-03 | 1.67e-02 | 25 |
GO:19045914 | Liver | Cirrhotic | positive regulation of protein import | 19/4634 | 43/18723 | 4.15e-03 | 2.22e-02 | 19 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DMAP1 | SNV | Missense_Mutation | novel | c.853G>A | p.Glu285Lys | p.E285K | Q9NPF5 | protein_coding | tolerated(0.31) | benign(0.333) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD |
DMAP1 | deletion | Frame_Shift_Del | novel | c.1016delA | p.Lys339ArgfsTer14 | p.K339Rfs*14 | Q9NPF5 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
DMAP1 | SNV | Missense_Mutation | c.807N>C | p.Gln269His | p.Q269H | Q9NPF5 | protein_coding | deleterious(0.02) | probably_damaging(0.995) | TCGA-DS-A0VM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | PD | |
DMAP1 | SNV | Missense_Mutation | novel | c.448N>C | p.Asp150His | p.D150H | Q9NPF5 | protein_coding | deleterious(0.01) | possibly_damaging(0.737) | TCGA-HM-A4S6-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | CR |
DMAP1 | SNV | Missense_Mutation | c.904C>G | p.Pro302Ala | p.P302A | Q9NPF5 | protein_coding | tolerated(0.42) | benign(0.023) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DMAP1 | SNV | Missense_Mutation | c.70N>T | p.Thr24Ser | p.T24S | Q9NPF5 | protein_coding | tolerated(0.72) | benign(0.005) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD | |
DMAP1 | SNV | Missense_Mutation | c.402N>T | p.Gln134His | p.Q134H | Q9NPF5 | protein_coding | tolerated(0.13) | benign(0.013) | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | |
DMAP1 | SNV | Missense_Mutation | novel | c.1126G>A | p.Glu376Lys | p.E376K | Q9NPF5 | protein_coding | deleterious(0) | probably_damaging(0.94) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
DMAP1 | SNV | Missense_Mutation | rs767182825 | c.1103G>A | p.Arg368Gln | p.R368Q | Q9NPF5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
DMAP1 | SNV | Missense_Mutation | rs767182825 | c.1103G>A | p.Arg368Gln | p.R368Q | Q9NPF5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |