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Gene: DECR1 |
Gene summary for DECR1 |
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Gene information | Species | Human | Gene symbol | DECR1 | Gene ID | 1666 |
Gene name | 2,4-dienoyl-CoA reductase 1 | |
Gene Alias | DECR | |
Cytomap | 8q21.3 | |
Gene Type | protein-coding | GO ID | GO:0001659 | UniProtAcc | Q16698 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1666 | DECR1 | HTA11_347_2000001011 | Human | Colorectum | AD | 9.91e-11 | 5.55e-01 | -0.1954 |
1666 | DECR1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 8.48e-03 | 4.84e-01 | 0.281 |
1666 | DECR1 | A001-C-207 | Human | Colorectum | FAP | 2.55e-02 | -1.54e-01 | 0.1278 |
1666 | DECR1 | A015-C-203 | Human | Colorectum | FAP | 2.31e-16 | -3.69e-01 | -0.1294 |
1666 | DECR1 | A015-C-204 | Human | Colorectum | FAP | 9.07e-05 | -2.14e-01 | -0.0228 |
1666 | DECR1 | A014-C-040 | Human | Colorectum | FAP | 1.85e-02 | -3.70e-01 | -0.1184 |
1666 | DECR1 | A002-C-201 | Human | Colorectum | FAP | 2.23e-07 | -2.44e-01 | 0.0324 |
1666 | DECR1 | A002-C-203 | Human | Colorectum | FAP | 1.33e-03 | -2.32e-01 | 0.2786 |
1666 | DECR1 | A001-C-119 | Human | Colorectum | FAP | 4.18e-05 | -4.02e-01 | -0.1557 |
1666 | DECR1 | A001-C-108 | Human | Colorectum | FAP | 1.29e-08 | -2.57e-01 | -0.0272 |
1666 | DECR1 | A002-C-205 | Human | Colorectum | FAP | 3.74e-15 | -3.54e-01 | -0.1236 |
1666 | DECR1 | A015-C-005 | Human | Colorectum | FAP | 1.89e-03 | -2.55e-01 | -0.0336 |
1666 | DECR1 | A015-C-006 | Human | Colorectum | FAP | 9.84e-11 | -3.13e-01 | -0.0994 |
1666 | DECR1 | A015-C-106 | Human | Colorectum | FAP | 1.33e-07 | -3.28e-01 | -0.0511 |
1666 | DECR1 | A002-C-114 | Human | Colorectum | FAP | 1.91e-12 | -3.34e-01 | -0.1561 |
1666 | DECR1 | A015-C-104 | Human | Colorectum | FAP | 8.49e-15 | -3.22e-01 | -0.1899 |
1666 | DECR1 | A001-C-014 | Human | Colorectum | FAP | 1.36e-05 | -1.96e-01 | 0.0135 |
1666 | DECR1 | A002-C-016 | Human | Colorectum | FAP | 4.84e-08 | -2.39e-01 | 0.0521 |
1666 | DECR1 | A015-C-002 | Human | Colorectum | FAP | 1.34e-06 | -3.06e-01 | -0.0763 |
1666 | DECR1 | A002-C-116 | Human | Colorectum | FAP | 5.34e-19 | -3.73e-01 | -0.0452 |
Page: 1 2 3 4 5 6 7 8 9 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00016592 | Liver | NAFLD | temperature homeostasis | 29/1882 | 174/18723 | 4.48e-03 | 3.61e-02 | 29 |
GO:01061063 | Liver | NAFLD | cold-induced thermogenesis | 25/1882 | 144/18723 | 4.66e-03 | 3.74e-02 | 25 |
GO:01201613 | Liver | NAFLD | regulation of cold-induced thermogenesis | 25/1882 | 144/18723 | 4.66e-03 | 3.74e-02 | 25 |
GO:000663112 | Liver | Cirrhotic | fatty acid metabolic process | 165/4634 | 390/18723 | 1.29e-14 | 1.26e-12 | 165 |
GO:004428211 | Liver | Cirrhotic | small molecule catabolic process | 151/4634 | 376/18723 | 2.20e-11 | 1.34e-09 | 151 |
GO:001605411 | Liver | Cirrhotic | organic acid catabolic process | 104/4634 | 240/18723 | 1.91e-10 | 9.53e-09 | 104 |
GO:004639511 | Liver | Cirrhotic | carboxylic acid catabolic process | 102/4634 | 236/18723 | 3.41e-10 | 1.63e-08 | 102 |
GO:001939512 | Liver | Cirrhotic | fatty acid oxidation | 53/4634 | 103/18723 | 4.73e-09 | 1.88e-07 | 53 |
GO:003444011 | Liver | Cirrhotic | lipid oxidation | 53/4634 | 108/18723 | 3.85e-08 | 1.27e-06 | 53 |
GO:007232911 | Liver | Cirrhotic | monocarboxylic acid catabolic process | 56/4634 | 122/18723 | 2.87e-07 | 7.01e-06 | 56 |
GO:000906211 | Liver | Cirrhotic | fatty acid catabolic process | 48/4634 | 100/18723 | 3.87e-07 | 9.13e-06 | 48 |
GO:000663512 | Liver | Cirrhotic | fatty acid beta-oxidation | 38/4634 | 74/18723 | 7.41e-07 | 1.57e-05 | 38 |
GO:004424212 | Liver | Cirrhotic | cellular lipid catabolic process | 82/4634 | 214/18723 | 6.91e-06 | 1.08e-04 | 82 |
GO:001604212 | Liver | Cirrhotic | lipid catabolic process | 112/4634 | 320/18723 | 2.31e-05 | 3.03e-04 | 112 |
GO:003025811 | Liver | Cirrhotic | lipid modification | 75/4634 | 212/18723 | 3.33e-04 | 2.87e-03 | 75 |
GO:000663122 | Liver | HCC | fatty acid metabolic process | 238/7958 | 390/18723 | 8.24e-14 | 4.84e-12 | 238 |
GO:004428221 | Liver | HCC | small molecule catabolic process | 225/7958 | 376/18723 | 6.50e-12 | 2.80e-10 | 225 |
GO:001605421 | Liver | HCC | organic acid catabolic process | 152/7958 | 240/18723 | 5.11e-11 | 1.92e-09 | 152 |
GO:00463952 | Liver | HCC | carboxylic acid catabolic process | 149/7958 | 236/18723 | 1.11e-10 | 3.87e-09 | 149 |
GO:004424222 | Liver | HCC | cellular lipid catabolic process | 134/7958 | 214/18723 | 2.07e-09 | 5.79e-08 | 134 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DECR1 | SNV | Missense_Mutation | c.129N>G | p.Phe43Leu | p.F43L | Q16698 | protein_coding | deleterious(0.04) | benign(0.01) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
DECR1 | SNV | Missense_Mutation | novel | c.171N>G | p.Phe57Leu | p.F57L | Q16698 | protein_coding | tolerated(0.73) | benign(0.021) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
DECR1 | SNV | Missense_Mutation | c.272N>C | p.Arg91Pro | p.R91P | Q16698 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-BH-A0AW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | SD | |
DECR1 | SNV | Missense_Mutation | c.470C>T | p.Ser157Phe | p.S157F | Q16698 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AA-3814-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
DECR1 | SNV | Missense_Mutation | c.737N>C | p.Lys246Thr | p.K246T | Q16698 | protein_coding | deleterious(0.01) | benign(0.224) | TCGA-AA-A01D-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | capecitabine | PD | |
DECR1 | SNV | Missense_Mutation | novel | c.776N>C | p.Glu259Ala | p.E259A | Q16698 | protein_coding | tolerated(0.07) | benign(0.043) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
DECR1 | SNV | Missense_Mutation | rs781613500 | c.53G>T | p.Gly18Val | p.G18V | Q16698 | protein_coding | tolerated_low_confidence(0.4) | benign(0) | TCGA-D5-6534-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DECR1 | SNV | Missense_Mutation | c.205N>G | p.Thr69Ala | p.T69A | Q16698 | protein_coding | deleterious(0) | probably_damaging(0.912) | TCGA-D5-6929-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | oxaliplatinum+ | SD | |
DECR1 | SNV | Missense_Mutation | novel | c.944N>T | p.Arg315Ile | p.R315I | Q16698 | protein_coding | tolerated(0.07) | benign(0.017) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
DECR1 | SNV | Missense_Mutation | novel | c.568N>A | p.Ala190Thr | p.A190T | Q16698 | protein_coding | tolerated(0.07) | possibly_damaging(0.554) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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