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Gene: DCTPP1 |
Gene summary for DCTPP1 |
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Gene information | Species | Human | Gene symbol | DCTPP1 | Gene ID | 79077 |
Gene name | dCTP pyrophosphatase 1 | |
Gene Alias | CDA03 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | Q9H773 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79077 | DCTPP1 | GSM4909286 | Human | Breast | IDC | 1.02e-04 | 2.05e-01 | 0.1081 |
79077 | DCTPP1 | GSM4909290 | Human | Breast | IDC | 1.11e-06 | 3.50e-01 | 0.2096 |
79077 | DCTPP1 | GSM4909293 | Human | Breast | IDC | 2.82e-03 | 2.54e-01 | 0.1581 |
79077 | DCTPP1 | GSM4909296 | Human | Breast | IDC | 6.71e-09 | 3.17e-01 | 0.1524 |
79077 | DCTPP1 | GSM4909298 | Human | Breast | IDC | 8.68e-05 | 2.65e-01 | 0.1551 |
79077 | DCTPP1 | GSM4909304 | Human | Breast | IDC | 6.24e-22 | 5.19e-01 | 0.1636 |
79077 | DCTPP1 | GSM4909305 | Human | Breast | IDC | 9.38e-06 | 3.33e-01 | 0.0436 |
79077 | DCTPP1 | GSM4909306 | Human | Breast | IDC | 5.21e-16 | 4.78e-01 | 0.1564 |
79077 | DCTPP1 | GSM4909307 | Human | Breast | IDC | 1.19e-04 | 3.14e-01 | 0.1569 |
79077 | DCTPP1 | GSM4909311 | Human | Breast | IDC | 6.29e-17 | -2.20e-02 | 0.1534 |
79077 | DCTPP1 | GSM4909312 | Human | Breast | IDC | 9.27e-05 | 1.39e-01 | 0.1552 |
79077 | DCTPP1 | GSM4909317 | Human | Breast | IDC | 9.25e-14 | 4.27e-01 | 0.1355 |
79077 | DCTPP1 | GSM4909319 | Human | Breast | IDC | 1.19e-24 | 2.01e-01 | 0.1563 |
79077 | DCTPP1 | GSM4909320 | Human | Breast | IDC | 1.40e-03 | 2.30e-01 | 0.1575 |
79077 | DCTPP1 | GSM4909321 | Human | Breast | IDC | 4.47e-07 | 1.51e-01 | 0.1559 |
79077 | DCTPP1 | brca1 | Human | Breast | Precancer | 3.01e-11 | 4.44e-01 | -0.0338 |
79077 | DCTPP1 | brca2 | Human | Breast | Precancer | 6.37e-09 | 3.30e-01 | -0.024 |
79077 | DCTPP1 | brca3 | Human | Breast | Precancer | 4.10e-03 | 2.61e-01 | -0.0263 |
79077 | DCTPP1 | M2 | Human | Breast | IDC | 9.73e-04 | 3.53e-01 | 0.21 |
79077 | DCTPP1 | NCCBC14 | Human | Breast | DCIS | 4.02e-07 | 2.00e-01 | 0.2021 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:190136117 | Esophagus | HGIN | organic cyclic compound catabolic process | 106/2587 | 495/18723 | 1.94e-06 | 7.13e-05 | 106 |
GO:007149626 | Esophagus | HGIN | cellular response to external stimulus | 71/2587 | 320/18723 | 2.77e-05 | 7.19e-04 | 71 |
GO:00196924 | Esophagus | HGIN | deoxyribose phosphate metabolic process | 16/2587 | 42/18723 | 7.90e-05 | 1.76e-03 | 16 |
GO:003166820 | Esophagus | HGIN | cellular response to extracellular stimulus | 56/2587 | 246/18723 | 9.05e-05 | 1.97e-03 | 56 |
GO:00092624 | Esophagus | HGIN | deoxyribonucleotide metabolic process | 16/2587 | 44/18723 | 1.51e-04 | 2.97e-03 | 16 |
GO:00093944 | Esophagus | HGIN | 2'-deoxyribonucleotide metabolic process | 15/2587 | 40/18723 | 1.62e-04 | 3.16e-03 | 15 |
GO:00092643 | Esophagus | HGIN | deoxyribonucleotide catabolic process | 12/2587 | 30/18723 | 3.62e-04 | 5.68e-03 | 12 |
GO:00463863 | Esophagus | HGIN | deoxyribose phosphate catabolic process | 12/2587 | 31/18723 | 5.17e-04 | 7.46e-03 | 12 |
GO:000911720 | Esophagus | HGIN | nucleotide metabolic process | 92/2587 | 489/18723 | 1.11e-03 | 1.36e-02 | 92 |
GO:000675320 | Esophagus | HGIN | nucleoside phosphate metabolic process | 93/2587 | 497/18723 | 1.25e-03 | 1.49e-02 | 93 |
GO:00092233 | Esophagus | HGIN | pyrimidine deoxyribonucleotide catabolic process | 8/2587 | 19/18723 | 2.40e-03 | 2.41e-02 | 8 |
GO:00092193 | Esophagus | HGIN | pyrimidine deoxyribonucleotide metabolic process | 9/2587 | 24/18723 | 3.33e-03 | 3.12e-02 | 9 |
GO:00062442 | Esophagus | HGIN | pyrimidine nucleotide catabolic process | 8/2587 | 21/18723 | 5.00e-03 | 4.19e-02 | 8 |
GO:00092005 | Esophagus | HGIN | deoxyribonucleoside triphosphate metabolic process | 7/2587 | 17/18723 | 5.21e-03 | 4.30e-02 | 7 |
GO:0034655110 | Esophagus | ESCC | nucleobase-containing compound catabolic process | 272/8552 | 407/18723 | 2.92e-18 | 2.90e-16 | 272 |
GO:004670018 | Esophagus | ESCC | heterocycle catabolic process | 286/8552 | 445/18723 | 1.12e-15 | 7.47e-14 | 286 |
GO:004427019 | Esophagus | ESCC | cellular nitrogen compound catabolic process | 288/8552 | 451/18723 | 3.03e-15 | 1.79e-13 | 288 |
GO:0071496111 | Esophagus | ESCC | cellular response to external stimulus | 215/8552 | 320/18723 | 4.29e-15 | 2.43e-13 | 215 |
GO:001943918 | Esophagus | ESCC | aromatic compound catabolic process | 295/8552 | 467/18723 | 1.09e-14 | 5.98e-13 | 295 |
GO:190136118 | Esophagus | ESCC | organic cyclic compound catabolic process | 307/8552 | 495/18723 | 9.99e-14 | 4.80e-12 | 307 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa012325 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa002405 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa0123212 | Esophagus | ESCC | Nucleotide metabolism | 59/4205 | 85/8465 | 1.67e-04 | 6.58e-04 | 3.37e-04 | 59 |
hsa0024012 | Esophagus | ESCC | Pyrimidine metabolism | 41/4205 | 58/8465 | 9.14e-04 | 2.92e-03 | 1.49e-03 | 41 |
hsa01232 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa00240 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa012321 | Liver | Cirrhotic | Nucleotide metabolism | 39/2530 | 85/8465 | 1.27e-03 | 6.73e-03 | 4.15e-03 | 39 |
hsa002401 | Liver | Cirrhotic | Pyrimidine metabolism | 27/2530 | 58/8465 | 5.31e-03 | 1.88e-02 | 1.16e-02 | 27 |
hsa002402 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012322 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa002403 | Liver | HCC | Pyrimidine metabolism | 44/4020 | 58/8465 | 9.34e-06 | 7.11e-05 | 3.95e-05 | 44 |
hsa012323 | Liver | HCC | Nucleotide metabolism | 59/4020 | 85/8465 | 3.30e-05 | 1.88e-04 | 1.04e-04 | 59 |
hsa012324 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa002404 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123211 | Oral cavity | OSCC | Nucleotide metabolism | 54/3704 | 85/8465 | 1.78e-04 | 5.95e-04 | 3.03e-04 | 54 |
hsa0024011 | Oral cavity | OSCC | Pyrimidine metabolism | 37/3704 | 58/8465 | 1.62e-03 | 4.45e-03 | 2.26e-03 | 37 |
hsa0123221 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0024021 | Oral cavity | LP | Pyrimidine metabolism | 28/2418 | 58/8465 | 1.12e-03 | 5.02e-03 | 3.24e-03 | 28 |
hsa0123231 | Oral cavity | LP | Nucleotide metabolism | 42/2418 | 85/8465 | 3.62e-05 | 2.36e-04 | 1.52e-04 | 42 |
hsa0024031 | Oral cavity | LP | Pyrimidine metabolism | 28/2418 | 58/8465 | 1.12e-03 | 5.02e-03 | 3.24e-03 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
DCTPP1 | SNV | Missense_Mutation | novel | c.232G>A | p.Glu78Lys | p.E78K | Q9H773 | protein_coding | tolerated(0.43) | benign(0.007) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response |
DCTPP1 | insertion | Frame_Shift_Ins | novel | c.167_168insTTCTCTGATGTGTCCCAAGTGCCCAGCGCATAGTAGGC | p.Leu57SerfsTer63 | p.L57Sfs*63 | Q9H773 | protein_coding | TCGA-BH-A0H9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
DCTPP1 | SNV | Missense_Mutation | c.45G>T | p.Glu15Asp | p.E15D | Q9H773 | protein_coding | tolerated(0.25) | benign(0) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
DCTPP1 | SNV | Missense_Mutation | rs747527404 | c.160N>T | p.Arg54Trp | p.R54W | Q9H773 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
DCTPP1 | SNV | Missense_Mutation | c.45N>T | p.Glu15Asp | p.E15D | Q9H773 | protein_coding | tolerated(0.25) | benign(0) | TCGA-AA-3811-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
DCTPP1 | deletion | Frame_Shift_Del | c.244delN | p.Gln82LysfsTer25 | p.Q82Kfs*25 | Q9H773 | protein_coding | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |||
DCTPP1 | SNV | Missense_Mutation | novel | c.295G>T | p.Val99Phe | p.V99F | Q9H773 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
DCTPP1 | SNV | Missense_Mutation | c.396N>G | p.His132Gln | p.H132Q | Q9H773 | protein_coding | tolerated(0.29) | benign(0.081) | TCGA-B5-A0JY-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicin | SD | |
DCTPP1 | SNV | Missense_Mutation | rs368588932 | c.295N>A | p.Val99Ile | p.V99I | Q9H773 | protein_coding | tolerated(0.06) | benign(0.088) | TCGA-B5-A3FC-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
DCTPP1 | SNV | Missense_Mutation | rs143083714 | c.331C>T | p.Arg111Cys | p.R111C | Q9H773 | protein_coding | tolerated(0.11) | possibly_damaging(0.849) | TCGA-BG-A220-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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