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Gene: CTSZ |
Gene summary for CTSZ |
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Gene information | Species | Human | Gene symbol | CTSZ | Gene ID | 1522 |
Gene name | cathepsin Z | |
Gene Alias | CTSX | |
Cytomap | 20q13.32 | |
Gene Type | protein-coding | GO ID | GO:0001763 | UniProtAcc | Q9UBR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1522 | CTSZ | GSM4909293 | Human | Breast | IDC | 9.34e-03 | 2.37e-01 | 0.1581 |
1522 | CTSZ | GSM4909295 | Human | Breast | IDC | 6.67e-05 | 4.74e-01 | 0.0898 |
1522 | CTSZ | GSM4909297 | Human | Breast | IDC | 1.29e-03 | 8.63e-02 | 0.1517 |
1522 | CTSZ | GSM4909308 | Human | Breast | IDC | 2.55e-02 | 2.68e-01 | 0.158 |
1522 | CTSZ | GSM4909311 | Human | Breast | IDC | 1.38e-14 | -2.41e-02 | 0.1534 |
1522 | CTSZ | GSM4909319 | Human | Breast | IDC | 2.10e-19 | -6.62e-03 | 0.1563 |
1522 | CTSZ | GSM4909321 | Human | Breast | IDC | 1.25e-04 | 7.12e-02 | 0.1559 |
1522 | CTSZ | brca1 | Human | Breast | Precancer | 3.88e-03 | 2.42e-01 | -0.0338 |
1522 | CTSZ | NCCBC11 | Human | Breast | DCIS | 1.41e-05 | 2.69e-01 | 0.1232 |
1522 | CTSZ | NCCBC14 | Human | Breast | DCIS | 7.62e-15 | 2.34e-01 | 0.2021 |
1522 | CTSZ | NCCBC3 | Human | Breast | DCIS | 8.20e-22 | 7.02e-01 | 0.1198 |
1522 | CTSZ | NCCBC5 | Human | Breast | DCIS | 1.01e-08 | 2.32e-01 | 0.2046 |
1522 | CTSZ | P1 | Human | Breast | IDC | 1.92e-09 | 1.16e-02 | 0.1527 |
1522 | CTSZ | DCIS2 | Human | Breast | DCIS | 3.13e-75 | 7.29e-01 | 0.0085 |
1522 | CTSZ | CA_HPV_1 | Human | Cervix | CC | 1.50e-15 | 6.56e-01 | 0.0264 |
1522 | CTSZ | N_HPV_2 | Human | Cervix | N_HPV | 3.17e-02 | 2.78e-01 | -0.0131 |
1522 | CTSZ | CCI_1 | Human | Cervix | CC | 2.88e-02 | -5.11e-01 | 0.528 |
1522 | CTSZ | CCI_3 | Human | Cervix | CC | 1.93e-04 | -5.24e-01 | 0.516 |
1522 | CTSZ | CCII_1 | Human | Cervix | CC | 4.22e-07 | -5.26e-01 | 0.3249 |
1522 | CTSZ | Tumor | Human | Cervix | CC | 1.76e-02 | -2.15e-01 | 0.1241 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00164854 | Cervix | N_HPV | protein processing | 15/534 | 225/18723 | 2.09e-03 | 2.00e-02 | 15 |
GO:004352514 | Cervix | N_HPV | positive regulation of neuron apoptotic process | 6/534 | 58/18723 | 6.04e-03 | 4.17e-02 | 6 |
GO:005110015 | Cervix | N_HPV | negative regulation of binding | 11/534 | 162/18723 | 6.86e-03 | 4.55e-02 | 11 |
GO:0051098 | Colorectum | AD | regulation of binding | 126/3918 | 363/18723 | 6.01e-10 | 4.88e-08 | 126 |
GO:0070997 | Colorectum | AD | neuron death | 114/3918 | 361/18723 | 1.13e-06 | 3.72e-05 | 114 |
GO:0043393 | Colorectum | AD | regulation of protein binding | 68/3918 | 196/18723 | 5.17e-06 | 1.34e-04 | 68 |
GO:1901214 | Colorectum | AD | regulation of neuron death | 99/3918 | 319/18723 | 1.26e-05 | 2.76e-04 | 99 |
GO:0045861 | Colorectum | AD | negative regulation of proteolysis | 106/3918 | 351/18723 | 2.33e-05 | 4.57e-04 | 106 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0051402 | Colorectum | AD | neuron apoptotic process | 77/3918 | 246/18723 | 8.07e-05 | 1.28e-03 | 77 |
GO:0060562 | Colorectum | AD | epithelial tube morphogenesis | 93/3918 | 325/18723 | 5.65e-04 | 6.00e-03 | 93 |
GO:0031345 | Colorectum | AD | negative regulation of cell projection organization | 58/3918 | 186/18723 | 6.37e-04 | 6.58e-03 | 58 |
GO:0051604 | Colorectum | AD | protein maturation | 85/3918 | 294/18723 | 6.73e-04 | 6.91e-03 | 85 |
GO:0043523 | Colorectum | AD | regulation of neuron apoptotic process | 64/3918 | 212/18723 | 8.95e-04 | 8.63e-03 | 64 |
GO:0060425 | Colorectum | AD | lung morphogenesis | 20/3918 | 50/18723 | 1.65e-03 | 1.38e-02 | 20 |
GO:0051100 | Colorectum | AD | negative regulation of binding | 50/3918 | 162/18723 | 1.84e-03 | 1.51e-02 | 50 |
GO:0010977 | Colorectum | AD | negative regulation of neuron projection development | 43/3918 | 137/18723 | 2.60e-03 | 1.97e-02 | 43 |
GO:1901216 | Colorectum | AD | positive regulation of neuron death | 32/3918 | 97/18723 | 3.74e-03 | 2.63e-02 | 32 |
GO:0043525 | Colorectum | AD | positive regulation of neuron apoptotic process | 21/3918 | 58/18723 | 5.25e-03 | 3.47e-02 | 21 |
GO:0001763 | Colorectum | AD | morphogenesis of a branching structure | 56/3918 | 196/18723 | 6.60e-03 | 4.09e-02 | 56 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa042108 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa0421013 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa0421022 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0421032 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0421041 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
hsa0421051 | Breast | DCIS | Apoptosis | 29/846 | 136/8465 | 5.92e-05 | 5.97e-04 | 4.40e-04 | 29 |
hsa042109 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421014 | Cervix | CC | Apoptosis | 36/1267 | 136/8465 | 3.21e-04 | 1.68e-03 | 9.91e-04 | 36 |
hsa0421042 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
hsa0421052 | Cervix | N_HPV | Apoptosis | 14/349 | 136/8465 | 1.40e-03 | 9.06e-03 | 7.08e-03 | 14 |
hsa04142 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa041421 | Colorectum | SER | Lysosome | 38/1580 | 132/8465 | 2.87e-03 | 2.03e-02 | 1.47e-02 | 38 |
hsa04210 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa042101 | Colorectum | MSS | Apoptosis | 44/1875 | 136/8465 | 3.66e-03 | 1.66e-02 | 1.01e-02 | 44 |
hsa0414222 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421027 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa0414232 | Esophagus | ESCC | Lysosome | 102/4205 | 132/8465 | 5.11e-11 | 7.13e-10 | 3.65e-10 | 102 |
hsa0421037 | Esophagus | ESCC | Apoptosis | 102/4205 | 136/8465 | 1.05e-09 | 1.21e-08 | 6.21e-09 | 102 |
hsa041424 | Liver | Cirrhotic | Lysosome | 68/2530 | 132/8465 | 1.34e-07 | 1.97e-06 | 1.21e-06 | 68 |
hsa042106 | Liver | Cirrhotic | Apoptosis | 58/2530 | 136/8465 | 9.84e-04 | 5.55e-03 | 3.42e-03 | 58 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
CTSZ | SNV | Missense_Mutation | c.731C>T | p.Ser244Phe | p.S244F | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
CTSZ | SNV | Missense_Mutation | c.867C>G | p.Asn289Lys | p.N289K | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.993) | TCGA-EW-A1OZ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Targeted Molecular therapy | trastuzumab | SD | |
CTSZ | SNV | Missense_Mutation | c.785N>T | p.Ser262Leu | p.S262L | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-C5-A1MP-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
CTSZ | SNV | Missense_Mutation | novel | c.668N>G | p.Ala223Gly | p.A223G | Q9UBR2 | protein_coding | tolerated(0.06) | benign(0.001) | TCGA-IR-A3LH-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
CTSZ | SNV | Missense_Mutation | rs748740856 | c.418N>A | p.Val140Met | p.V140M | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
CTSZ | SNV | Missense_Mutation | rs201081854 | c.335N>T | p.Ala112Val | p.A112V | Q9UBR2 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
CTSZ | SNV | Missense_Mutation | novel | c.718N>C | p.Asn240His | p.N240H | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
CTSZ | SNV | Missense_Mutation | rs201081854 | c.335N>T | p.Ala112Val | p.A112V | Q9UBR2 | protein_coding | tolerated(0.12) | benign(0.015) | TCGA-F4-6856-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Ancillary | leucovorin | CR |
CTSZ | SNV | Missense_Mutation | rs202127342 | c.580N>A | p.Gly194Ser | p.G194S | Q9UBR2 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
CTSZ | SNV | Missense_Mutation | rs368797360 | c.880N>A | p.Glu294Lys | p.E294K | Q9UBR2 | protein_coding | tolerated(0.53) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1522 | CTSZ | DRUGGABLE GENOME, PROTEASE, ENZYME | inhibitor | 178103092 | ODANACATIB |
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